亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
国产亚洲精品中文带字幕21页,小货SAO边洗澡边CAO你动漫
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-phospho-Erk1 (Thr202 + Tyr204) /Cy5 Conjugated antibody (bs-1645R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-1645R-Cy5
英文名稱 Rabbit Anti-phospho-Erk1 (Thr202 + Tyr204) /Cy5 Conjugated antibody
中文名稱 Cy5標記的磷酸化絲裂原活化蛋白激酶1抗體
別    名 Erk1 (pT202/pY204); ERK/MAPK(phospho T202/Y204); ERK1 (phospho T202); p-ERK1 (phospho T202); p44/42 MAP Kinase(Phospho-Thr202); ERK; ERK-1; ERT 2; ERT2; Extracellular Signal Regulated Kinase 1; Extracellular signal related kinase 1; Extracellular signal-regulated kinase 1; HGNC6877; HS44KDAP; HUMKER1A; Insulin Stimulated MAP2 Kinase; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP Kinase; MAP kinase isoform p44; MAPK 1; MAPK 3; MAPK; MAPK1; Mapk3; MGC20180; Microtubule Associated Protein 2 Kinase; Microtubule-associated protein 2 kinase; Mitogen Activated Protein Kinase 3; Mitogen-activated protein kinase 1; Mitogen-activated protein kinase 3; MK03_HUMAN; OTTHUMP00000174538; OTTHUMP00000174541; p44 ERK1; p44 MAPK; p44-ERK1; p44-MAPK; P44ERK1; P44MAPK; PRKM 3; PRKM3; Protein Kinase Mitogen Activated 3.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 免疫學  神經生物學  信號轉導  干細胞  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Chicken, Dog, Cow, Horse, Rabbit, Guinea Pig, )
產品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 43kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from rat ERK1 around the phosphorylation site of Thr201/204
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.

Function:
Serine/threonine kinase which acts as an essentialcomponent of the MAP kinase signal transduction pathway. MAPK1/ERK2and MAPK3/ERK1 are the 2 MAPKs which play an important role in theMAPK/ERK cascade. They participate also in a signaling cascadeinitiated by activated KIT and KITLG/SCF. Depending on the cellularcontext, the MAPK/ERK cascade mediates diverse biological functionssuch as cell growth, adhesion, survival and differentiation throughthe regulation of transcription, translation, cytoskeletalrearrangements. The MAPK/ERK cascade plays also a role ininitiation and regulation of meiosis, mitosis, and postmitoticfunctions in differentiated cells by phosphorylating a number oftranscription factors. About 160 substrates have already beendiscovered for ERKs. Many of these substrates are localized in thenucleus, and seem to participate in the regulation of transcriptionupon stimulation. However, other substrates are found in thecytosol as well as in other cellular organelles, and those areresponsible for processes such as translation, mitosis andapoptosis. Moreover, the MAPK/ERK cascade is also involved in theregulation of the endosomal dynamics, including lysosome processingand endosome cycling through the perinuclear recycling compartment(PNRC); as well as in the fragmentation of the Golgi apparatusduring mitosis. The substrates include transcription factors (suchas ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements(such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1),regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3,MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and avariety of other signaling-related molecules (like ARHGEF2, FRS2 orGRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2,RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases(such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates whichenable the propagation the MAPK/ERK signal to additional cytosolicand nuclear targets, thereby extending the specificity of thecascade.

Subunit:
Binds both upstream activators and downstream substratesin multimolecular complexes. Found in a complex with at least BRAF,HRAS1, MAP2K1/MEK1, MAPK3 and RGS14. Interacts with ADAM15, ARRB2,CANX, DAPK1 (via death domain), HSF4, IER3, MAP2K1/MEK1, MORG1,NISCH, PEA15, SGK1 and MKNK2 (By similarity). MKNK2 isoform 1binding prevents from dephosphorylation and inactivation. Interactswith TPR (By similarity).

Subcellular Location:
Cytoplasm (By similarity). Nucleus.Note=Autophosphorylation at Thr-207 promotes nuclear localization(By similarity). PEA15-binding redirects the biological outcome ofMAPK3 kinase-signaling by sequestering MAPK3 into the cytoplasm (Bysimilarity).
Isoform 2: Nucleus.

Tissue Specificity:
Highest levels within the nervous system,expressed in different tissues, mostly in intestine, placenta andlung.

Post-translational modifications:
Phosphorylated upon FLT3 and KIT signaling. Ligand-activatedALK induces tyrosine phosphorylation (By similarity).Dephosphorylated by PTPRJ at Tyr-205 (By similarity). Duallyphosphorylated on Thr-203 and Tyr-205, which activates the enzyme.

Similarity:
Belongs to the protein kinase superfamily. CMGCSer/Thr protein kinase family. MAP kinase subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 5594 Human

Entrez Gene: 5595 Human

Entrez Gene: 116590 Rat

Entrez Gene: 50689 Rat

SwissProt: P27361 Human

SwissProt: P28482 Human

SwissProt: P21708 Rat

SwissProt: P63086 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
2020精品国产自在现线官网 | 手机永久免费的AV在线电影网无码 | 黑人玩弄极品人妻系列 | 亚洲国产精品嫩草影院在线观看 | 美女裸身露双奶头无遮挡免费视频 | 日本欧美激情视频二区 | 国产一级特黄妇女A片 | 久久91久久91精品免费观看 | 国产一级片内射毛片中出91 | 国产一区在线观看免费 | 国产午夜精品一区二区三区软件 | 少妇爆乳无码av无码专区在 | 精品成a人亚洲精品无码 | 伊人久久大香线蕉亚洲五月天 | 午夜特爽爽爽爽爽爽黄片 | www夜片内射视频日韩精品成人 | 亚洲日本欧美产综合在线 | 人妻久久相姦中文字幕 | 久久精品国产亚洲AV影院 | 五月天精品视频在线观看 | 精品久久久久久久一区二区 | 琪琪亚洲AV永久无码精品无码 | 亚洲AV无码一区二区二三区 | 伴郎粗大的内捧猛烈进出视频观看 | 国内精品51视频在线观看 | 国产偷窥熟女精品视频大全 | 精品福利一区二区三区免费视频 | 亚洲欧美日韩在线视频 | 日韩中文字幕免费的视频在线看网站 | 国产日韩欧美另类 | 91av视频在线观看 | 亚洲欧美乱日韩乱国产 | 一级黄色香蕉视频 | 澳门永久av免费网站 | 先峰中文字幕一二三区 | 亚洲国产精品嫩草影院在线观看 | 国产精品1区2区 | 亚洲高清在线精品一区 | 麻豆亚洲精品中文字幕一麻豆 | 久久久久久久久久久免费精品国产 | 亚洲第一天堂WWW网站 |