亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产精品网站在线观看免费传媒,91人妻无码精品一区二区毛片
Rabbit Anti-Notch3/Cy5 Conjugated antibody (bs-1812R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-1812R-Cy5
英文名稱 Rabbit Anti-Notch3/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的跨膜受體蛋白Notch-3抗體
別    名 CADASIL; CASIL; NOTC3_HUMAN; Notch 3; Notch 3 intracellular domain; Notch homolog 3; Notch3.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 染色質(zhì)和核信號  神經(jīng)生物學(xué)  干細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 255kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouae Notch3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]

Function:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

Subunit:
Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with PSMA1. Interacts with HIF1AN.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Notch 3 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.

Tissue Specificity:
Ubiquitously expressed in fetal and adult tissues.

Post-translational modifications:
Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.
Phosphorylated.
Hydroxylated by HIF1AN.

DISEASE:
Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL) [MIM:125310]: A cerebrovascular disease characterized by multiple subcortical infarcts, pseudobulbar palsy, dementia, and the presence of granular deposits in small cerebral arteries producing ischemic stroke. Note=The disease is caused by mutations affecting the gene represented in this entry.
Myofibromatosis, infantile 2 (IMF2) [MIM:615293]: A rare mesenchymal disorder characterized by the development of benign tumors in the skin, striated muscles, bones, and, more rarely, visceral organs. Subcutaneous or soft tissue nodules commonly involve the skin of the head, neck, and trunk. Skeletal and muscular lesions occur in about half of the patients. Lesions may be solitary or multicentric, and they may be present at birth or become apparent in early infancy or occasionally in adult life. Visceral lesions are associated with high morbidity and mortality. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the NOTCH family.
Contains 5 ANK repeats.
Contains 34 EGF-like domains.
Contains 3 LNR (Lin/Notch) repeats.

Database links:

Entrez Gene: 4854 Human

Entrez Gene: 18131 Mouse

Entrez Gene: 56761 Rat

Omim: 600276 Human

SwissProt: Q9UM47 Human

SwissProt: Q61982 Mouse

SwissProt: Q9R172 Rat

Unigene: 8546 Human

Unigene: 439741 Mouse

Unigene: 53876 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Notch3是保守的Ⅰ型跨膜受體,Notch3信號通路在機(jī)體發(fā)育過程中調(diào)控細(xì)胞生長、分化和凋亡等多種重要生物學(xué)過程。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
少妇被黑人到高潮喷出白浆 | 国产成人一区二区三区在线观看 | 亚洲A∨无码精品午夜电影 高清欧美在线三级视频 | 内射无码AV-区二区在线观看 | 亚洲精品无码久久久久久久久 | 亚洲精品高清一二区久久 | 精品自拍视频五区六区在线观看 | 午夜婷婷一夜七次郎 | 在电影院嗯啊挺进去了啊视频 | 日韩欧美国产偷亚洲清高 | 亚洲成色WWW久久网站夜月 | 亚洲国产精彩中文乱码AV | 中文字幕秘 一区二区人妻 成人国产一区二区精品小说 | 日产精品美女久久久网站大全 | 日韩精品一区二区三区免费视频 | 在线观看日本污污ww网站 | 91热久久免费频精品动漫99 | 中文字幕永久天天综合 | 久久久久久久Aⅴ无码免费网站 | 国产女人水真多18毛片18精品 | 国产精品99久久久久久 | 国产精品久久久久久搜索 | 成年网站免费视频A在线双飞 | 免费AA片少妇人AA片直播 | 国产制服91一区二区三区制服 | 爆乳3把你榨干哦OVA在线观看 | 一区二区视频在线观看高清视频在线 | 未满小14洗澡无码视频网站 | 拍国产真实乱人偷精品 | 欧美又大粗又爽又黄大片视频 | 日韩一级视频在线观看播放 | 国产AV无码一二三区天堂 | 日本国产一区二区三区 | 国产精品美女自在线观看免费 | 91精品国产成人网在线观看 | 色综合久久综合网欧美综合网 | 国产精品乱码久久久久久 | 性荡视频播放器在线视频播放 | 国产美女69视频免费观看 | 成全视频在线观看免费高清版 | 连续高潮抽搐爽死喷水流白浆无码 |