亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
99精品亚洲国产精品久久不卡,免费一级毛片不卡在线播放
Rabbit Anti-Notch3/PE Conjugated antibody (bs-1812R-PE)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1812R-PE
英文名稱 Rabbit Anti-Notch3/PE Conjugated antibody
中文名稱 PE標(biāo)記的跨膜受體蛋白Notch-3抗體
別    名 CADASIL; CASIL; NOTC3_HUMAN; Notch 3; Notch 3 intracellular domain; Notch homolog 3; Notch3.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  干細(xì)胞  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 255kDa
細(xì)胞定位 細(xì)胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouae Notch3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]

Function:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

Subunit:
Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with PSMA1. Interacts with HIF1AN.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Notch 3 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.

Tissue Specificity:
Ubiquitously expressed in fetal and adult tissues.

Post-translational modifications:
Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.
Phosphorylated.
Hydroxylated by HIF1AN.

DISEASE:
Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL) [MIM:125310]: A cerebrovascular disease characterized by multiple subcortical infarcts, pseudobulbar palsy, dementia, and the presence of granular deposits in small cerebral arteries producing ischemic stroke. Note=The disease is caused by mutations affecting the gene represented in this entry.
Myofibromatosis, infantile 2 (IMF2) [MIM:615293]: A rare mesenchymal disorder characterized by the development of benign tumors in the skin, striated muscles, bones, and, more rarely, visceral organs. Subcutaneous or soft tissue nodules commonly involve the skin of the head, neck, and trunk. Skeletal and muscular lesions occur in about half of the patients. Lesions may be solitary or multicentric, and they may be present at birth or become apparent in early infancy or occasionally in adult life. Visceral lesions are associated with high morbidity and mortality. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the NOTCH family.
Contains 5 ANK repeats.
Contains 34 EGF-like domains.
Contains 3 LNR (Lin/Notch) repeats.

Database links:

Entrez Gene: 4854 Human

Entrez Gene: 18131 Mouse

Entrez Gene: 56761 Rat

Omim: 600276 Human

SwissProt: Q9UM47 Human

SwissProt: Q61982 Mouse

SwissProt: Q9R172 Rat

Unigene: 8546 Human

Unigene: 439741 Mouse

Unigene: 53876 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Notch3是保守的Ⅰ型跨膜受體,Notch3信號(hào)通路在機(jī)體發(fā)育過(guò)程中調(diào)控細(xì)胞生長(zhǎng)、分化和凋亡等多種重要生物學(xué)過(guò)程。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
色狠狠一区二区三区熟女91 | 国产乱女乱子视频在线播放 | 亚洲精品国产高清不卡在线 | 情浓野战台湾三级 | 自拍偷区亚洲综合第一页欧18 | 最好看的最新的中文字幕1 中文字幕AV在线一二三区 | 亚洲成色WWW久久网站夜月 | 善良娇妻在老汉跨下呻吟 | 永久免费看啪啪网址入口 | 视频一区视频二区在线观看 | 国产女人十八毛片A级毛片 综合欧美亚洲首页在线播放 | 欧美午夜性春猛交XXXX | 免费国产成人高清在线视频 | 久久久久人妻精品一区5555 | 国产精品VIDEOSSEX久久发布 | 免费的很污的很黄的网站 | 免费国产成人高清在线视频 | 国产日韓无码一区二区三区久久区 | sg99.xy丝瓜视频| 欧美成人免费观看久久 | 性奴抽插乳中出精没射视频搜索 | 三个男人躁我一个爽是什么剧 | 中国一级毛片视频 | 成人国产999视频在线观看 | 国产普通话对白呻吟在线 | 亚洲国产一区二区精品专区发布 | 久久久久久久久久久免费精品国产 | 最新亚洲中文字幕一区在线 | 中文字幕无码家庭乱欲 | 国产久爱青草视频在线观看 | 中文字幕在线一区二区三区 | 亚洲不卡av不卡一区二区 | 日产亚洲一区二区三区 | 久久99AV无色码人妻蜜 | 国产v亚洲v天堂a无码 | 小呦精品导航网站 | 上海少妇高潮狂叫喷水了 | 全肉野战高h含苞欲 | 精品乱码久久久久久中文字幕 | 久久精品无码日韩国产不卡 | 恩恩呜呜好大好爽快点 |