亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
懂色av无码aV天天aV天天爽,色综合伊人色综合网站,一区三区三区不卡
Rabbit Anti-Notch3/PE-Cy5.5 Conjugated antibody (bs-1812R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1812R-PE-Cy5.5
英文名稱 Rabbit Anti-Notch3/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的跨膜受體蛋白Notch-3抗體
別    名 CADASIL; CASIL; NOTC3_HUMAN; Notch 3; Notch 3 intracellular domain; Notch homolog 3; Notch3.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 染色質(zhì)和核信號(hào)  神經(jīng)生物學(xué)  干細(xì)胞  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 255kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from mouae Notch3
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]

Function:
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.

Subunit:
Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with PSMA1. Interacts with HIF1AN.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Notch 3 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus.

Tissue Specificity:
Ubiquitously expressed in fetal and adult tissues.

Post-translational modifications:
Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.
Phosphorylated.
Hydroxylated by HIF1AN.

DISEASE:
Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy, autosomal dominant (CADASIL) [MIM:125310]: A cerebrovascular disease characterized by multiple subcortical infarcts, pseudobulbar palsy, dementia, and the presence of granular deposits in small cerebral arteries producing ischemic stroke. Note=The disease is caused by mutations affecting the gene represented in this entry.
Myofibromatosis, infantile 2 (IMF2) [MIM:615293]: A rare mesenchymal disorder characterized by the development of benign tumors in the skin, striated muscles, bones, and, more rarely, visceral organs. Subcutaneous or soft tissue nodules commonly involve the skin of the head, neck, and trunk. Skeletal and muscular lesions occur in about half of the patients. Lesions may be solitary or multicentric, and they may be present at birth or become apparent in early infancy or occasionally in adult life. Visceral lesions are associated with high morbidity and mortality. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the NOTCH family.
Contains 5 ANK repeats.
Contains 34 EGF-like domains.
Contains 3 LNR (Lin/Notch) repeats.

Database links:

Entrez Gene: 4854 Human

Entrez Gene: 18131 Mouse

Entrez Gene: 56761 Rat

Omim: 600276 Human

SwissProt: Q9UM47 Human

SwissProt: Q61982 Mouse

SwissProt: Q9R172 Rat

Unigene: 8546 Human

Unigene: 439741 Mouse

Unigene: 53876 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Notch3是保守的Ⅰ型跨膜受體,Notch3信號(hào)通路在機(jī)體發(fā)育過程中調(diào)控細(xì)胞生長、分化和凋亡等多種重要生物學(xué)過程。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
宅男午夜大片又黄又爽大片 | 亚洲熟妇av一区二区三区色堂 | 国产乱精品自在线免费 | 亚洲欧美日韩综合在线观看 | 亚洲国产另类久久久精品 | 给我免费播放片高清在线观看 | 色欲av伊人久久大香线蕉影院 | 国产二级一片内射视频播放 | 亚洲中文字幕AV在天堂 | 果冻传媒剧国产MV在线看 | 国产V片在线播放免费无码 日韩在线视频一区二区三区 | 天天做天天添天天谢 | 国产精品无码ThePorn | 国产无线乱码一区二三区 | 亚洲熟女乱色一区二区三区 | 精品久久久久成人码免费动漫 | 免费国产动漫美女被靠的视频 | 国产中文在线观看 | 亚州免费一级毛片 | 国产一区二区在线免费观看 | 水蜜桃AV无码专区亚洲AV麻豆 | 日韩大片高清播放器大全 | 狠狠色丁香婷婷综合 | 国产美女一级做a爱视频 | av春色-精品少妇人妻av无码 | 夜鲁夜鲁很鲁在线视频视频 | 麻豆精品久久久一区二区 | 国产女高清在线看免费观看 | 亚洲最大的熟女水蜜桃AV网站 | 内射极品少妇XXXXXHD | 肉到痉挛中出痴汉在线播放 | 国产在线观看无码免费视频 | 国产丰满大乳无码免费播放 | 国产成人一区二区三区在线观看 | aaaaaa级特色特黄的毛片 | 高清精品美女在线播放 | 少妇无码太爽了不卡视频在线看 | 寡妇高潮一级毛片免费看 | 女人扒开腿让男人狂桶30分钟 | 好爽毛片一区二区三区色欲 | 国产激情久久久久99蜜桃小说 |