亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
99久久国产精品无码专区,大香伊蕉在人线国产最新75
Rabbit Anti-HDAC3/Biotin Conjugated antibody (bs-1819R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1819R-Bio
英文名稱 Rabbit Anti-HDAC3/Biotin Conjugated antibody
中文名稱 生物素標(biāo)記的組蛋白去乙酰化酶3抗體
別    名 RPD3 2; RPD3-2; HD 3; HD3; HDAC 3; Histone deacetylase 3 (HD3) (RPD3-2); histone deacetylase 3; RPD 3; RPD3; SMAP 45; SMAP-45; SMAP45; HDAC3_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  發(fā)育生物學(xué)  轉(zhuǎn)錄調(diào)節(jié)因子  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, )
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human HDAC3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].

Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.

Subunit:
Interacts with HDAC7 and HDAC9. Forms a heterologous complex at least with YY1. Interacts with DAXX, HDAC10 and DACH1. Found in a complex with NCOR1 and NCOR2. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with BCOR, MJD2A/JHDM3A, NRIP1, PRDM6 and SRY. Interacts with BTBD14B. Interacts with GLIS2. Interacts (via the DNA-binding domain) with NR2C1; the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Component of the Notch corepressor complex. Interacts with CBFA2T3 and NKAP. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1. Interacts with and deacetylates MAPK14. Interacts with ZMYND15.

Subcellular Location:
Nucleus.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Sumoylated in vitro.

Similarity:
Belongs to the histone deacetylase family. HD type 1 subfamily.

Database links:

Entrez Gene: 8841 Human

Entrez Gene: 15183 Mouse

Entrez Gene: 84578 Rat

Omim: 605166 Human

SwissProt: O15379 Human

SwissProt: O88895 Mouse

SwissProt: Q6P6W3 Rat

Unigene: 519632 Human

Unigene: 20521 Mouse

Unigene: 17284 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

組蛋白去乙?;?HDACs)是一組在細(xì)胞染色質(zhì)水平、通過誘導(dǎo)組蛋白去乙?;瘉碚{(diào)控包括染色質(zhì)重組、轉(zhuǎn)錄活化或抑制、細(xì)胞周期、細(xì)胞分化及細(xì)胞凋亡等一系列生物學(xué)效應(yīng)的酶,特別是與細(xì)胞活化后的基因轉(zhuǎn)錄表達(dá)調(diào)控有關(guān)。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
天堂网在线最新版www资源网 | 亚洲美女又黄又爽在线观看 | 国产无线乱码一区二三区 | 日本内射精品一区二区视频 | 色欲久久精品亚洲AV无码一区 | 免费伦费一区二区三区四区 | 美女被C污黄网站免费观看 又粗又硬女人免费视频 | 亚洲啪AV永久无码精品放毛片 | 欧美精品成人一区二区在线观看 | 国产精品内射婷婷一级二 | 国产精品老熟女视频一区二区 | 国产精品成人影院在线观看 | 无码人妻AⅤ一区二区三区夏目 | 国产sm精品调教在线 | 精品国产天堂综合一区在线 | 日本不卡一区二区三区 | 四虎影视成人永久免费观看视频 | 四虎影视永久免费观看 | 免费毛片网站在线观看 | 欧美日韩激情在线一区二区三区 | 亚洲精品无码久久久久久久久 | 日韩AV在线高清免费毛片 | 亚洲欧美一区二区久久 | 白丝校花扒腿让我c在线观看 | 无码av高清毛片在线看 | 日韩一区精品视频一区二区 | 把手戳进美女尿口里动态图 | 高潮毛片无遮挡免费高清 | 在线无码一区二区三区不卡 | 无线日本视频精品 | 91精品国产综合久久久久久一区黄网无码 | 91精品国产色综合久久不卡美美 | 醉酒后少妇被疯狂内射视频 | 亚洲已满18点击进入在线观看 | Q人妻精品内射-AV | 女人高潮内射99精品 | 国产特黄级AAAAA片免 | 中文字幕丰满乱孑伦无码专区 | 亚洲AⅤ永久无码精品毛片费观看 | 欧美一区二区三区久久综 | 欧美自拍亚洲精品动图 |