亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
午夜福利电影网站鲁片大全,一本久到久久亚洲综合
Rabbit Anti-LEF-1/BF350 Conjugated antibody (bs-1843R-BF350)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1843R-BF350
英文名稱 Rabbit Anti-LEF-1/BF350 Conjugated antibody
中文名稱 BF350標(biāo)記的淋巴增強因子-1抗體
別    名 lymphoid enhancing factor-1; Transcription factor T cell specific 1 alpha ; DKFZp586H0919; LEF 1; LEF1; Lymphoid enhancer binding factor 1; T cell specific transcription factor 1 alpha; TCF 1 alpha; TCF1 alpha; TCF1alpha; TCF1-alpha; LEF1_HUMAN; Lymphoid enhancer-binding factor 1; LEF-1; T cell-specific transcription factor 1-alpha.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 免疫學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Chicken, Dog, Pig, Cow, Rabbit, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LEF-1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].

Function:
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

Subunit:
Binds the armadillo repeat of CTNNB1 and forms a stable complex. Interacts with EP300, TLE1 and PIASG (By similarity). Binds ALYREF/THOC4, MDFI and MDFIC. Interacts with NLK.

Subcellular Location:
Nucleus. Note=Found in nuclear bodies upon PIASG binding.

Tissue Specificity:
Detected in thymus. Not detected in normal colon, but highly expressed in colon cancer biopsies and colon cancer cell lines. Expressed in several pancreatic tumors and weakly expressed in normal pancreatic tissue. Isoforms 1 and 5 are detected in several pancreatic cell lines.

Post-translational modifications:
Phosphorylated at Thr-155 and/or Ser-166 by NLK. Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway.

Similarity:
Belongs to the TCF/LEF family.
Contains 1 HMG box DNA-binding domain.

Database links:

Entrez Gene: 51176 Human

Omim: 153245 Human

SwissProt: Q9UJU2 Human

Unigene: 726506 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

lef-1是淋巴增強因子/T-細胞因子(LEF/TCF)家族的成員之一,屬于高遷移率組分蛋白家族。lef-1也是一個重要的轉(zhuǎn)錄因子,是Wnt信號通路的核心成分。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
亚洲AV产在线精品亚洲第一站 | 好吊妞色视频在线观看 | 亚洲AV无码久久久久久精品酒店 | 青青草99久久精品国产综合 | 国产h视频在线观看免费 | 我把护士日出水了视频90分钟 | 99国产一区二区三区亚洲一区影院午夜 | 国产又猛又黄又爽 | 第一天破了英语课代表的处 | 全黄H全肉短篇禁乱NP慕浅浅 | 亚洲综合精品一二三区在线 | 日本韩国亚洲综合日韩欧美国产 | 《久久国产91成人免费网站 | 欧美精品视频在线观看视频 | 国产欧美日本在线 | 和上司交换娇妻在线播放 | 成年香蕉大黄美女美女 | 久久久久亚洲Av片无码 | 中文字幕一级毛片无码视频 | 99久久国产精品亚洲综合看片 | 91精品国产无码高清 | 最新亚洲中文字幕一区在线 | 久久经典免费视频 | 中文字幕乱妇无码AV在线 | 亚洲一区欧洲一区 | 免费午夜无码18禁无码影视 | 亚洲女精品一区二区三区 | 成人欧美一区二区三区白人 | 欧美精品黄页在线观看视频 | 人妻少妇精品视频一区97精品 | 久久99免费视频 | 性色AV一区二区三区V视界影院 | 日韩美乳诱惑专区 | 高清视频黄色录像免费 | 亚洲人AV永久一区二区三区久久 | 国产主播AV福利精品一区 | 天堂资源在线WWW中文 | 韩国日本免费高清观看网址 | 伦人伦 XXX国语对白 | 免费国产va在线观看中文字 | 国产三级视频在线 |