亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产91av在线播放网站,亚洲精品无码不卡在线播HE
Rabbit Anti-NSE2/MMS21/PE Conjugated antibody (bs-9544R-PE)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-9544R-PE
英文名稱 Rabbit Anti-NSE2/MMS21/PE Conjugated antibody
中文名稱 PE標(biāo)記的E3連接酶MMS21蛋白抗體
別    名 C8orf36; E3 SUMO-protein ligase NSE2; hMMS21; hNSE2; methyl methanesulfonate sensitivity gene 21; MMS21; MMS21 homolog; non-SMC element 2; Non-SMC element 2 homolog; Non-structural maintenance of chromosomes element 2 homolog; NSE2_HUMAN; NSMCE2.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  細(xì)胞凋亡  表觀遺傳學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MMS21/NSE2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Breaks in double stranded DNA often arise during DNA replication or as a result of exposure to DNA-damaging agents. Quick and accurate repair of these breaks is crucial for cell survival and genomic stability. Structural maintenance of chromosomes (SMC) family members form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation during mitosis. SMC5 and SMC6 play a crucial role in DNA repair as they form a complex with six conserved nonSMC subunits, including a ubiquitin E3 ligase NSE1 and a SUMO ligase NSE2. Specifically, this complex is crucial for sister chromatid homologous recombination DNA repair and also for prevention of chromosomal rearrangements. The NSE1 protein contains a RING-like motif that promotes DNA repair functions of the SMC5/SMC6 complex and full deletion of NSE1 is lethal to cells. NSE2 stimulates sumoylation of SMC6 and the DNA repair protein TRAX. Depletion of the NSE2 protein by RNA interference leaves the cell vulnerable to DNA damage-induced apoptosis.

Function:
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

Subunit:
Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2.

Subcellular Location:
Nucleus.Chromosome, telomere. Note=Localizes to PML nuclear bodies in ALT cell lines.

Post-translational modifications:
Sumoylated, possibly via autosumoylation.

Similarity:
Belongs to the NSE2 family.
Contains 1 SP-RING-type zinc finger.

Database links:

Entrez Gene: 286053 Human

SwissProt: Q96MF7 Human

Unigene: 388297 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
日韩精品国产另类专区 | 国产午夜免费视频片夜色 | 亚洲国产一区二区精品专区发布 | 国产亚洲tv在线观看 | 亚洲欧美一区二区久久 | 亚洲AV无码乱码在线观看性色 | 黄视频在线免费看 | 麻豆精品一区二正一三区 | 亚洲春色AV无码专区 | 内射人妻无码色AV无码 | 国产女人十八毛片A级毛片 综合欧美亚洲首页在线播放 | 亚洲精品免费视频观看视频 | 成全视频观看免费高清动漫 | 激情动图欧美一区二区 | 日韩一级视频在线观看播放 | 一级黄色毛片播放 | 欧美亚洲另类日韩图片区 | 亚洲AV无码专区在线观看在线 | 久久窝窝国产精品午夜看片 | 国产久爱青草视频在线观看 | 欧美一区二区三区播放 | 久久国内精品自在自线 | 国产精品人人爽人人做Av片 | 国产成人手机高清在线观看网站 | 洗澡被公强奷30分钟在线观看 | 91看片淫黄大片在看 | 日韩美女做暖暖免费视频 | 欧美乱色伦图片区小说 | 粗大的内捧猛烈进出视频网 | 狠狠人妻久久久久久综合 | 国产精品沙发午睡系列990531 | 免费的很污的很黄的网站 | 日本中文字幕有码在线视频 | 国产手机在线国内精品 | 狂躁美女大BBBBBB视频U | 久久特级av一级毛片 | 亚洲午夜尤物中文字幕在线 | 少妇人妻一级A毛片无码 | 老师奶头好大我要摸视频 | 内射国产老熟女综合导航 | 国产黄在线观看免费观看不卡 |