亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产AV国片精品一区二区,欧美一级特黄AAAAAAAA片在线看
Rabbit Anti-NSE2/MMS21/PE-Cy5 Conjugated antibody (bs-9544R-PE-Cy5)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-9544R-PE-Cy5
英文名稱 Rabbit Anti-NSE2/MMS21/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的E3連接酶MMS21蛋白抗體
別    名 C8orf36; E3 SUMO-protein ligase NSE2; hMMS21; hNSE2; methyl methanesulfonate sensitivity gene 21; MMS21; MMS21 homolog; non-SMC element 2; Non-SMC element 2 homolog; Non-structural maintenance of chromosomes element 2 homolog; NSE2_HUMAN; NSMCE2.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  細(xì)胞凋亡  表觀遺傳學(xué)  泛素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 28kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human MMS21/NSE2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Breaks in double stranded DNA often arise during DNA replication or as a result of exposure to DNA-damaging agents. Quick and accurate repair of these breaks is crucial for cell survival and genomic stability. Structural maintenance of chromosomes (SMC) family members form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation during mitosis. SMC5 and SMC6 play a crucial role in DNA repair as they form a complex with six conserved nonSMC subunits, including a ubiquitin E3 ligase NSE1 and a SUMO ligase NSE2. Specifically, this complex is crucial for sister chromatid homologous recombination DNA repair and also for prevention of chromosomal rearrangements. The NSE1 protein contains a RING-like motif that promotes DNA repair functions of the SMC5/SMC6 complex and full deletion of NSE1 is lethal to cells. NSE2 stimulates sumoylation of SMC6 and the DNA repair protein TRAX. Depletion of the NSE2 protein by RNA interference leaves the cell vulnerable to DNA damage-induced apoptosis.

Function:
E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair.

Subunit:
Component of the SMC5-SMC6 complex which consists at least of SMC5, SMC6, NSMCE2, NSMCE1, NSMCE4A or EID3 and NDNL2.

Subcellular Location:
Nucleus.Chromosome, telomere. Note=Localizes to PML nuclear bodies in ALT cell lines.

Post-translational modifications:
Sumoylated, possibly via autosumoylation.

Similarity:
Belongs to the NSE2 family.
Contains 1 SP-RING-type zinc finger.

Database links:

Entrez Gene: 286053 Human

SwissProt: Q96MF7 Human

Unigene: 388297 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
色综合精品无码一区二区三区 | 精品人妻少妇久久久AV | 女人高潮内射99精品 | 中文字幕无码乱码人妻系列 | 欧美日韩亚洲一区二区三区在线观看 | 国模丽丽啪啪一区二区 | 女人高潮爽到全身痉挛抽搐 | 国产精品久久久久精品一级APP | 欧美日韩人妻精品一区在线 | 日产乱码一区二区三区在线 | 香蕉苹果水蜜桃丝瓜视频 | 精品欧洲视频人人视频网站 | 国产真实老熟女无套内射 | 国产国拍亚洲精品永久软件 | 精品人妻伦九区久久AAA片 | 日韩一区二区三区精品 | 2021av一二三级视频在线观看亚洲 | 茄子在线看片免费人成视频 | 又小又紧女MAGNET | 国产无遮挡又黄又爽在线视频 | 色欲精品国产一区二区三区AV | 伊人婷婷六月狠狠狠去 | 成人欧美一区二区三区白人 | √新版天堂资源在线资源 | 慢点换个姿势进的好深啊小说 | 日韩欧美一中文字慕2O22 | 2018国产精华国产精品 | 18视频入口网站在线看 | 色妞AV永久一区二区国产AV开 | 中文字幕欧美另类精品亚洲 | 在线欧美精品一区二区三区 | 91精品国产自产在线观看 | 中文字幕人成人乱码亚洲电影 | 久久久久精品日韩久久久 | 人人超碰人人爽人人添 | 成年女人色费视频免费 | 欧美性猛交aaaaa免费看 | 欧美精品视频在线观看视频 | 国内毛片毛片毛片毛片毛片毛片毛片毛片毛片毛片毛片毛片 | 麻豆一区产品精品蜜桃的广告语 | 国产制服91一区二区三区制服 |