| 產(chǎn)品編號 | bs-11137R-BF488 |
| 英文名稱 | Rabbit Anti-IL-28R/BF488 Conjugated antibody |
| 中文名稱 | BF488標(biāo)記的白細(xì)胞介素28受體抗體 |
| 別 名 | Alternative namesIFNLR; Class II cytokine receptor CRF2/12; CRF2/12; Cytokine receptor family 2 member 12; IFN lambda R1; IFNLR1; il-28r1; IL28R alpha; Interferon lambda receptor 1; Interferon lambda receptor; Interleukin 28 receptor alpha chain; LICR2; Likely interleukin or cytokine receptor 2.I28RA_HUMAN |
| 規(guī)格價格 | 100ul/2980元 購買 大包裝/詢價 |
| 說 明 書 | 100ul |
| 研究領(lǐng)域 | 腫瘤 細(xì)胞生物 免疫學(xué) G蛋白偶聯(lián)受體 G蛋白信號 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, ) |
| 產(chǎn)品應(yīng)用 | ICC=1:50-200 IF=1:50-200
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55kDa |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IL-28R |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol |
| 保存條件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 產(chǎn)品介紹 |
background: IL-28R is a 535 amino acid protein encoded by the human gene IL28RA. IL-28R belongs to the type II cytokine receptor family and contains 1 fibronectin type-III domain. It is a single-pass type I membrane protein found as a heterodimer with IL-10RB. This is a receptor for a small family of structurally-related cytokines that, like IFNs, are known to induce antiviral activity. The expression of IFN-I (IL-28) mRNA is inducible by viral infection in several cell lines. The receptor complex (IL-28R) that is utilized by all three IFN-l proteins for signaling is composed of two subunits, a receptor designated IL-28R and IL-10R2. Both receptor chains are constitutively expressed on a wide variety of human cell lines and tissues and signal through the Jak-STAT (Janus kinases-signal transducers and activators of transcription) pathway. Function: IL28RA is a class II cytokine receptor that interacts with IL10RB to bind IL28A, IL28B, and IL29, which are related to type I interferons. These ligands play a critical role in response to microbial challenge and activate the JAK/STAT signaling system. It heterodimers with IL10RB. There are 4 isoforms as result of alternative splicing. It is widely expressed. IL28RA belongs to the type II cytokine receptor family, and contains 1 fibronectin type III domain. Subunit: Heterodimer with IL10RB. Subcellular Location: Membrane; Single-pass type I membrane protein Tissue Specificity: Widely expressed. Similarity: Belongs to the type II cytokine receptor family. Contains 1 fibronectin type-III domain. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
