亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
美女被抽插到哭内射视频免费,日韩国产自产拍av在线
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-phospho-Tau (Thr522)/Cy3 Conjugated antibody (bs-10113R-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-10113R-Cy3
英文名稱 Rabbit Anti-phospho-Tau (Thr522)/Cy3 Conjugated antibody
中文名稱 Cy3標記的磷酸化微管相關(guān)蛋白抗體
別    名 Tau(Phospho-Thr522); MAPT(phospho T522); p-Tau protein (phospho-Thr522); MAPT; Microtuble-associted protein Tau; AI413597; AW045860; DDPAC; Disinhibition dementia parkinsonism amyotrophy complex; FLJ31424; FTDP 17; FTDP17; G Protein beta 1 gamma 2 subunit interacting factor 1; G protein beta1/gamma2 subunit interacting factor 1; MAPTL; MGC134287; MGC138549; MGC156663; Microtubule associated protein tau isoform 4; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; Paired helical filament tau; PHF tau; PHF-tau; PPND; pTau; RNPTAU; Tauopathy and respiratory failure, included; TAU_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 細胞生物  免疫學  神經(jīng)生物學  信號轉(zhuǎn)導  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Dog, Horse, Rabbit, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 52/79kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Tau protein around the phosphorylation site of Thr522
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Function:
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Subunit:
Interacts with PSMC2 through SQSTM1. Interacts with SQSTM1 when polyubiquitinated. Interacts with FKBP4. Binds to CSNK1D. Interacts with SGK1.

Subcellular Location:
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.

Tissue Specificity:
Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Post-translational modifications:
Phosphorylation at serine and threonine residues in S-P or T-P motifs by proline-directed protein kinases (PDPK1: CDK1, CDK5, GSK3, MAPK) (only 2-3 sites per protein in interphase, seven-fold increase in mitosis, and in the form associated with paired helical filaments (PHF-tau)), and at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Phosphorylation decreases with age. Phosphorylation within tau/MAP's repeat domain or in flanking regions seems to reduce tAU/MAP's interaction with, respectively, microtubules or plasma membrane components. Phosphorylation on Ser-610, Ser-622, Ser-641 and Ser-673 in several isoforms during mitosis. Phosphorylation at Ser-548 by GSK3B reduces ability to bind and stabilize microtubules. Phosphorylation at Ser-579 by BRSK1 and BRSK2 in neurons affects ability to bind microtubules and plays a role in neuron polarization. Phosphorylated at Ser-554, Ser-579, Ser-602, Ser-606 and Ser-669 by PHK. Phosphorylation at Ser-214 by SGK1 mediates microtubule depolymerization and neurite formation in hippocampal neurons. There is a reciprocal down-regulation of phosphorylation and O-GlcNAcylation. Phosphorylation on Ser-717 completely abolishes the O-GlcNAcylation on this site, while phosphorylation on Ser-713 and Ser-721 reduces glycosylation by a factor of 2 and 4 respectively. Phosphorylation on Ser-721 is reduced by about 41.5% by GlcNAcylation on Ser-717.

DISEASE:
Defects in MAPT are a cause of Pick disease of the brain (PIDB) [MIM:172700]. It is a rare form of dementia pathologically defined by severe atrophy, neuronal loss and gliosis. It is characterized by the occurrence of tau-positive inclusions, swollen neurons (Pick cells) and argentophilic neuronal inclusions known as Pick bodies that disproportionally affect the frontal and temporal cortical regions. Clinical features include aphasia, apraxia, confusion, anomia, memory loss and personality deterioration.

Similarity:
Contains 4 Tau/MAP repeats.

Database links:

Entrez Gene: 281296 Cow

Entrez Gene: 4137 Human

Entrez Gene: 17762 Mouse

Entrez Gene: 29477 Rat

Omim: 157140 Human

SwissProt: P29172 Cow

SwissProt: P10636 Human

SwissProt: P10637 Mouse

SwissProt: P19332 Rat

Unigene: 101174 Human

Unigene: 1287 Mouse

Unigene: 2455 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

P-tau蛋白是腦內(nèi)神經(jīng)元細胞支架蛋白之一。其正常功能是促進微管蛋白組成微管,并維持已形成微管的穩(wěn)定性。參與維持細胞形態(tài)、信息傳遞、細胞分裂等重要生物學過程,是軸突生長發(fā)育和神經(jīng)元極性形成的不可缺少因素。近年來發(fā)現(xiàn)tau蛋白與一些中樞神經(jīng)系統(tǒng)變性疾病密切相關(guān),尤其是神經(jīng)Tau具有啟動微管系統(tǒng)的裝配以及穩(wěn)定微管系統(tǒng)的作用,該蛋白的錯誤折疊與老年性癡呆等神經(jīng)退行性疾病密切相關(guān)。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
黄色网站在线免费观看 | 国产手机在线视频 | 91精品久久久久久久久久小网站 | 久久丁香婷深爱五月天网 | 亚洲国产中文字幕在线观看 | 最新日韩中文字幕 | 欧美日本在线不卡二区 | WWW国产成人免费观看视频 | 六月婷婷国产精品综合 | 欧美自拍另类综合专区 | 少妇人妻AV毛片在线看 | 高清国产激情视频在线观看 | 精品国产人成亚洲区 | 欧美2021精品AⅤ | 国产成人精品电影在线观看 | 精品欧洲视频人人视频网站 | 2020精品极品国产色在线观看 | 国产精品香蕉在线的人 | 色欲狠狠躁天天躁无码中文字幕 | 高潮毛片无遮挡高清免费视频 | 日本黄H兄妹H动漫一区二区三区 | 60老熟女多次高潮露脸视频 | 性一交一无一伦一精一品的意思 | 国产精品乱码久久久久久 | 内射人妻无套中出无码 | 97久久超碰国产精品2021 | 99无码熟妇丰满人妻啪啪 | 久久久久久久久免费视频 | a级毛片黄免费a级毛片 | 日韩一区精品视频一区二区 | 不卡在线播放一区二区三区 | 亚洲欧美一区二区三区久久 | 免费看高视频hh网站免费 | 免费国产黄网站在线观看可以下载 | 狂躁美女大BBBBBB视频U | 成人永久免费国产乱码二区三区视频在线 | 亚洲日韩国产AV无码无码精品 | 开心片色99xxxx | 无码不卡中文字幕一区二区三区 | 久久国产一区二区三区 | 免费一级毛片不卡在线播放 |