亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
色婷婷综合激情中文在线,国产一区二区无码中文
Rabbit Anti-Ephexin-1/BF594 Conjugated antibody (bs-11458R-BF594)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-11458R-BF594
英文名稱 Rabbit Anti-Ephexin-1/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的神經(jīng)細(xì)胞鳥(niǎo)苷酸置換因子NGEF抗體
別    名 ARHGEF27; Eph-interacting exchange protein; EPHEXIN; Ephexin 1; Neuronal guanine nucleotide exchange factor; Ngef; NGEF_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  G蛋白偶聯(lián)受體  G蛋白信號(hào)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 82kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human EPHEXIN (451-550aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
EPHEXIN is a 710 amino acid protein that localizes to both the membrane and the cytoplasm and contains one SH3 domain, one PH domain and one DH domain. Expressed at high levels in brain and present at lower levels in lung tissue, EPHEXIN interacts with EphA4 and functions as a guanine nucleotide exchange factor (GEF) that is capable of activating Rho A, Rac 1 and Cdc42 and is thought to play a role in axon guidance and growth cone collapse. EPHEXIN is subject to Src-dependent phosphorylation, an event that increases the GEF activity of EPHEXIN toward Rho A. Human EPHEXIN, which exists as multiple alternatively spliced isoforms, shares a high degree of sequence homology with its mouse counterpart, suggesting a conserved role between species.

Function:
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1-and CDC42-stimulated growth cone extension.

Subunit:
Interacts with CDK5R1 and EPHA4; activated by EPHA4 through the CDK5 kinase

Subcellular Location:
Cytoplasm. Membrane. Cell projection, growth cone. Associated with membranes. Localizes to axonal growth cones.

Tissue Specificity:
Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung.

Post-translational modifications:
Src-dependent phosphorylation at Tyr-179 upon EPHA4 activation increases the guanine exchange factor activity toward RHOA.

Similarity:
Contains 1 DH (DBL-homology) domain.
Contains 1 PH domain.
Contains 1 SH3 domain.

Database links:

Entrez Gene: 25791 Human

Entrez Gene: 53972 Mouse

Entrez Gene: 246217 Rat

Entrez Gene: 424744 Chicken

Omim: 605991 Human

SwissProt: Q8N5V2 Human

SwissProt: Q8CHT1 Mouse

SwissProt: Q5BKC9 Rat

Unigene: 97316 Human

Unigene: 435439 Mouse

Unigene: 20670 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲欧美日本韩国 | 91精品国产高清一区二区三密臀 | A级毛片高清免费视频就看 亚洲AV无码片一区二区三区 | 2021亚洲无码视频 | 99久久国产综合精品麻豆导演 | 免费精品一区二区三区在线观看 | 日本一道高清一区二区三区 | 人妖欧美一区二区三区四区 | 日本黄H兄妹H动漫一区二区三区 | 欧美乱妇日本无乱码特黄大片 | 成人网站在线进入爽爽爽 | 成 人 黄 色 免费 网站无毒 | 久久国产AVJUST麻豆 | 中文字幕一区视频一线 | 国产99久久久久久免费看 | 好舒服好粗好硬免费视频 | 国产精品久久久天天影视香蕉 | 九九在线中文字幕无码 | 免费播放巨茎人妖不卡片 | 国产在线观看免费一级 | 国产亚洲欧美日韩综合一区在线观看 | 无码专区久久综合久综合字幕 | 国产精品JK白丝AV网站 | 粉嫩METART人体欣赏 | 丰满少妇被猛烈高清播放 | 亚洲 色无码专区在线 | 涩涩网站在线观看 | 50岁老熟女露脸25分钟91 | 日韩一区二无码专区播放 | 亚洲欧洲中文日韩AV无码 | 国产乱人伦偷精品视频免下载 | 色国产精品一区在线观看 | 久久er热在这里只有精品 | 少妇性荡欲午夜性开放视频剧场 | 国产精品伦一区二区三级视频 | 久久久橹橹橹久久久久高清 | www.999精品视频观看免费 | 高清无码视频在线观看 | 最近2019年中文字幕视频 | 国产AV一区二区高潮久久 | 国产性自爱拍偷在在线播放 |