亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
www.99在线,国产精品无码无卡A级毛片,99亚洲男女激情在线观看
Rabbit Anti-KIBRA/Cy5.5 Conjugated antibody (bs-11570R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-11570R-Cy5.5
英文名稱 Rabbit Anti-KIBRA/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標(biāo)記的腎臟和腦蛋白抗體
別    名 HBeAg-binding protein 3; HBEBP36; KIAA0869; KIBRA; Kidney and brain protein; Protein KIBRA; Protein WWC1; WW and C2 domain containing 1; WW C2 and coiled-coil domain containing 1; WW domain-containing protein 1; WWC1; KIBRA_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Dog, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 125kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KIBRA (351-450aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
KIBRA is a 1,113 amino acid protein that localizes to the cytoplasm and contains one C2 domain and two WW domains. Expressed in colon, brain, kidney and heart tissue, KIBRA is thought to interact with dendrin and, via this interaction, may play a role in collagen-induced signaling. Additionally, KIBRA, which exists as multiple alternatively spliced isoforms, is involved in memory performance and in the pathogenesis of Alzheimer's disease. The gene encoding KIBRA maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Function:
KIBRA is a WW domain containing protein, first identified by yeast 2-hybrid analysis of a human brain cDNA expression library. Gene expression studies have shown that KIBRA is expressed in memory-related brain structures including the hippocampus (dentate gyrus and the CA1 region) and the temporal lobe, 2 key regions for memory, and that the expression of specific KIBRA alleles is significantly associated with memory performance.

Subunit:
Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with INADL (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4.

Subcellular Location:
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Co-localizes with PRKCZ in the perinuclear region.

Tissue Specificity:
Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct.

Similarity:
Belongs to the WWC family. KIBRA subfamily.
Contains 1 C2 domain.
Contains 2 WW domains.

Database links:

Entrez Gene: 23286 Human

Omim: 610533 Human

SwissProt: Q8IX03 Human

Unigene: 484047 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
两口子交换真实刺激高潮 | 国产成人AV一区二区三区无码 | 精品成a人亚洲精品无码 | 性做久久久久久久久浪潮 | 欧美性猛交AAAA片黑人 | 韩国日本免费高清观看网址 | 很狠干线观看2021 | 男女免费观看在线爽爽爽视频 | 国产精品中文原创AV巨作首播 | 亚洲国产成人精品女人久久久 | 国产在线精品福利大全 | 无码精品人妻一区二美国区三区 | 国产乱码精品一区二区三区四川 | 亚洲中文字幕无码视频 | 精品久久久久久无码不卡 | 欧美在线视频一区 | 日韩视频在线精品视频免费观看 | 欧美又大粗又爽又黄大片视频 | 天天综合网网欲色 | 女人被弄到高潮的免费视频 | 在线观着免费观看国产黄 | 风韵丰满熟妇啪啪区老熟熟女 | 大学生高潮无套内谢视频 | 国产一区二区精品久久岳 | 黄色一级片免费网站 | 情浓野战台湾三级 | 在线播放极太黑炮vs绝伦美女 | 国内精品久久久久影院久久久91 | 美女内射毛片在线看3D | 性一交一无一伦一精一爆 | 日韩欧美一区二区三区在线 | 欧美一级毛片在播放免费 | 国产内射在线激情一区 | 国产乱码精品一区二区三区中文 | 国产精品99国产精品久久 | 九九热视频精品在线观看 | 超碰97人人做人人爱亚洲尤物 | 欧美激情视频一区二区三区不卡 | 国产午夜亚洲精品 | 91久久精品国产免费一区金莲 | 13小箩利无码视频网站免费 |