亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
依恋社区影院网在线观看,yellow片免费观看在线,2020精品国产自在现线官网
Rabbit Anti-KIBRA/BF488 Conjugated antibody (bs-11570R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-11570R-BF488
英文名稱 Rabbit Anti-KIBRA/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的腎臟和腦蛋白抗體
別    名 HBeAg-binding protein 3; HBEBP36; KIAA0869; KIBRA; Kidney and brain protein; Protein KIBRA; Protein WWC1; WW and C2 domain containing 1; WW C2 and coiled-coil domain containing 1; WW domain-containing protein 1; WWC1; KIBRA_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Dog, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 125kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KIBRA (351-450aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
KIBRA is a 1,113 amino acid protein that localizes to the cytoplasm and contains one C2 domain and two WW domains. Expressed in colon, brain, kidney and heart tissue, KIBRA is thought to interact with dendrin and, via this interaction, may play a role in collagen-induced signaling. Additionally, KIBRA, which exists as multiple alternatively spliced isoforms, is involved in memory performance and in the pathogenesis of Alzheimer's disease. The gene encoding KIBRA maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Function:
KIBRA is a WW domain containing protein, first identified by yeast 2-hybrid analysis of a human brain cDNA expression library. Gene expression studies have shown that KIBRA is expressed in memory-related brain structures including the hippocampus (dentate gyrus and the CA1 region) and the temporal lobe, 2 key regions for memory, and that the expression of specific KIBRA alleles is significantly associated with memory performance.

Subunit:
Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with INADL (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4.

Subcellular Location:
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Co-localizes with PRKCZ in the perinuclear region.

Tissue Specificity:
Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct.

Similarity:
Belongs to the WWC family. KIBRA subfamily.
Contains 1 C2 domain.
Contains 2 WW domains.

Database links:

Entrez Gene: 23286 Human

Omim: 610533 Human

SwissProt: Q8IX03 Human

Unigene: 484047 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
人妻无码熟妇乱又伦精品 | 亚洲熟妇无码爱V在线观 | 成人无码片黄网站A毛片免费 | 2020精品极品国产色在线观看 | 亚洲性夜夜综合久久麻豆 | 免费国产黄线在线观看 | 消息称久青青国产高清视频 | 96视频人澡人澡日日 | 久久久久久久Aⅴ无码免费网站 | 久久99蜜桃精品久久久久 | 国产大爆乳大爆乳在线播放 | 中文字幕大香视频蕉无码... | 国产欧美日韩精品一区二区三区蜜桃不卡 | 久激情内射婷内射蜜桃人妖 | 人妻无码精品蜜桃HD91精品国产 | 中文字幕永久天天综合 | 野花高清在线观看免费 | 黄色网站在线免费观看 | 欧亚成年男女深夜百度网盘 | 美妇吞吐粗长撞击迎合 | 欧美.日韩.日本国产视频 | 国产又爽又黄无码无遮挡在线观看 | 亚洲成a人片在线观看无码专区 | 免费无码又爽又刺激网站直播 | 久久99久国产精品黄毛片 | 亚洲二区在线视频 | 国产精品亚洲专区在线播放 | 亚洲AV怡红院AV男人的天堂 | 无码爽到爆高潮抽搐喷水在线观看 | 亚洲日韩国产AV无码无码精品 | 免费无码又爽又黄又刺激网站 | 亚洲精品成a人在线观看 | 特黄三级又爽又粗又大 | 在线观看黄网视频免费播放 | 在线永久免费观看黄网站 | 桃花岛t亚洲品质自拍 | 东北少妇不戴套对白第一次 | 国精产品999一区二区三区有限 | 最近最新免费手机中文 | 九九热线有精品免费观看 | 午夜成人性爽爽免费视频 |