亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
久久久久久成人毛片免费看,国产三级视频在线播放线观看,国产精品成人一区二区无码欠欠源
Rabbit Anti-KIBRA/PE-Cy7 Conjugated antibody (bs-11570R-PE-Cy7)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-11570R-PE-Cy7
英文名稱 Rabbit Anti-KIBRA/PE-Cy7 Conjugated antibody
中文名稱 PE-Cy7標(biāo)記的腎臟和腦蛋白抗體
別    名 HBeAg-binding protein 3; HBEBP36; KIAA0869; KIBRA; Kidney and brain protein; Protein KIBRA; Protein WWC1; WW and C2 domain containing 1; WW C2 and coiled-coil domain containing 1; WW domain-containing protein 1; WWC1; KIBRA_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Dog, Cow, Rabbit, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 125kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human KIBRA (351-450aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
KIBRA is a 1,113 amino acid protein that localizes to the cytoplasm and contains one C2 domain and two WW domains. Expressed in colon, brain, kidney and heart tissue, KIBRA is thought to interact with dendrin and, via this interaction, may play a role in collagen-induced signaling. Additionally, KIBRA, which exists as multiple alternatively spliced isoforms, is involved in memory performance and in the pathogenesis of Alzheimer's disease. The gene encoding KIBRA maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Function:
KIBRA is a WW domain containing protein, first identified by yeast 2-hybrid analysis of a human brain cDNA expression library. Gene expression studies have shown that KIBRA is expressed in memory-related brain structures including the hippocampus (dentate gyrus and the CA1 region) and the temporal lobe, 2 key regions for memory, and that the expression of specific KIBRA alleles is significantly associated with memory performance.

Subunit:
Homodimer. Interacts with DDN. Interacts with DYNLL1 and histone H3. The interaction with DYNLL1 is mandatory for the recruitment and transactivation functions of ESR1 or DYNLL1 to the target chromatin and the interaction with histone H3 ensures proper regulatory interaction of WWC1-DYNLL1-ESR1 complexes with target chromatin. Interacts (via WW domains) with DDR1 (via PPxY motif) in a collagen-regulated manner. Interacts with PRKCZ (via the protein kinase domain). Forms a tripartite complex with DDR1 and PRKCZ, but predominantly in the absence of collagen. Interacts (via the ADDV motif) with INADL (via PDZ domain 8). Interacts (via WW domains) with SYNPO (via PPxY motifs). Interacts with NF2 and SNX4.

Subcellular Location:
Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Cell projection, ruffle membrane. Note=Co-localizes with PRKCZ in the perinuclear region.

Tissue Specificity:
Expressed in mammary epithelial cells and breast cancer cell lines. Found in the luminal epithelium surrounding the ducts in the normal breast. In the brain, expressed in somatodendritic compartment of neurons in the cortex and hippocampus and in the cerebellum it is found in the Purkinje cells and some granule cells (at protein level). Detected in brain, heart, colon and kidney. In the kidney, expressed in glomerular podocytes, in some tubules and in the collecting duct.

Similarity:
Belongs to the WWC family. KIBRA subfamily.
Contains 1 C2 domain.
Contains 2 WW domains.

Database links:

Entrez Gene: 23286 Human

Omim: 610533 Human

SwissProt: Q8IX03 Human

Unigene: 484047 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产精品成人影院在线观看 | 久久久又黄又爽免费观看下载 | 久久精品www人人爽人人 | 成年必看视频在线观看 | 欧美精品在线一区二区三区 | 嫩草在线视频WWW免费看 | 啊灬啊灬啊灬快灬少妇 | 巜豪妇荡乳2在线观看 | 亚洲91无码精品一区在线播放 | 娇妻被领导玩整夜不停 | 国产JLZZJLZZ视频免费看 | 久久99精品久久久久久清纯直播 | 未满小14洗澡无码视频网站 | 国产成人精品美女在线 | 性生交片免费无码看人 | 久久99久久66精品99久久综合 | 最好看的最新的中文字幕1 中文字幕AV在线一二三区 | 国内毛片毛片毛片毛片毛片毛片毛片毛片毛片毛片毛片毛片 | 手机在线精品视频 | Q人妻精品内射-AV | 性高湖久久久久久久久 | 亚洲精品初高中精品久久自慰网站 | 久久www免费人成高清 | 乱码视频午夜间在线观看 | 性短视频在线观看免费不卡流畅 | 色婷婷久综合久久一本国产AV | 成人免费毛片AAAAAA片 | 精品人妻无码中文字幕第一区 | 午夜A级理论片左线播放 | 999在线视频精品免费播放观看 | 欧美又大又粗又硬又色A片 国产精品久久久天天影视香蕉 | 日本不卡高字幕在线2019 | 校园久久综合激情四射伊人丁香 | 熟妇丰满大屁股在线播放BBW | 秋葵视频ios无限制解码免费版下载 | 免费的人成黄网站在线观看视频 | 国产成人精品久久综合 | 全黄H全肉禁乱公 | 妖精视频一区二区免费 | √新版天堂资源在线资源 | 日本丰满熟妇被捏出奶水 |