亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
91普通话国产对白在线,四虎影视成人永久免费观看视频,久久免费观看视频
Rabbit Anti-PPP1R10/RBITC Conjugated antibody (bs-11666R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-11666R-RBITC
英文名稱 Rabbit Anti-PPP1R10/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的絲氨酸/蘇氨酸蛋白磷酸酶1調(diào)節(jié)亞基10抗體
別    名 PNUTS; CAT 53; CAT53; FB 19; FB19; FB19 protein; MHC class I region proline rich protein CAT53; p99; Phosphatase 1 nuclear targeting subunit; Phosphatase nuclear targeting subunit; PNUTS; PP1 binding protein of 114 kDa; PP1R10; Protein phosphatase 1 regulatory (inhibitor) subunit 10; Protein phosphatase 1 regulatory subunit 10; Serine/threonine protein phosphatase 1 regulatory subunit 10; PP1RA_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  激酶和磷酸酶  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 99kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human PPP1R10
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Eukaryotic protein phosphorylation and dephosphorylation on serine and threonine residues regulates numerous cell functions, including division, homeostasis and apoptosis. A group of proteins that play a major role in this process are the serine/threonine protein phosphatases. Protein phosphatase (PP) holoenzyme is a trimeric complex that contains a regulatory subunit, a variable subunit and a catalytic subunit. Families of PP catalytic subunits include PP1, PP2A, PP2B, PP2C, PPX and PP5. Regulatory subunits include nuclear inhibitor of PP1 (NIPP1), PP1 nuclear targeting subunit (PNUTS), PP2A-A, PP2A-B, PP2A-B56, PP2A-C, PP2B-B and PR48. PNUTS, also designated CAT53 or FB19, is encoded by the gene PPP1R10. PNUTS acts as an inhibitor for the phosphatase activity of PP1 Alpha and PP1 Gamma. It is a nuclear protein primarily detected in nucleoplasmic bodies and within nucleoli. PNUTS expression levels are highest in brain, heart, lung, placenta, liver, kidney, pancreas and skeletal muscle.

Function:
PPP1R10 (serine/threonine protein phosphatase 1 regulatory subunit 10), also known as PNUTS, is a targeting subunit of protein phosphatase 1 (PP1). Furthermore, PPP1R10 acts as an inhibitor of PPP1CA and PPP1CC phosphatase activities. Its inhibitory activity on PPP1CA is only observed when PPP1R10 is phosphorylated by Protein Kinase A (PKA). PPP1R10 contains a zinc finger motif and is predominantly localised within the nucleus. Recently, PPP1R10 has been shown to target PP1 to GABA(C) receptors, shuttling from the nucleus to the cell membrane in cells co-expressing this receptor. This highlights a role for this protein in the regulation of synaptic signal transduction. PPP1R10 has also been shown to regulate the activity of p53 in response to hypoxia.

Subunit:
Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4

Subcellular Location:
Nucleus. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase

Tissue Specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Post-translational modifications:
Phosphorylated on Ser-398 and Thr-400 by PKA within the region necessary for interaction with PPP1CA

Similarity:
Contains 1 C3H1-type zinc finger.
Contains 1 TFIIS N-terminal domain.

Database links:

Entrez Gene: 5514 Human

Omim: 603771 Human

SwissProt: Q96QC0 Human

Unigene: 106019 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
欧美成人精品午夜免费影视 | 艳妇臀荡乳欲伦69调教视频 | 亚洲综合另类欧美久久久久精品 | 日本成人黄色网址 | 60老熟女多次高潮露脸视频 | 国产后进白嫩翘臀在线动漫 | 最美女人体内射精一区二区 | 99国产精品一区二区三区四区五区 | 日韩精品亚洲一区二区三区 | 澳门一级特黄录像免费播黄 | 国产精品美女乱子伦高 | 亚洲国产欧美经典三级 | 囯产免费一区二区三区 | 一区二区视频在线观看高清视频在线 | 国产午夜免费视频片夜色 | 美女隐私黄www视频 日本电影亚洲欧美精品素人 | 嫩交18xxxx| 国产女人被狂躁到高潮小说 | 理论片87福利理论电影 | 91精品久久久久久久久久 | 日产亚洲一区二区三区 | 亚洲国产精品嫩草影院在线观看 | 久久久久久精品免费免费WE | 性妇WBBBB搡BBBB嗓小说 | 国产探花在线精品一区二区 | 国产精品视频26uuu | 欧美A级毛欧美1级a大片式放 | 超级最爽的乱淫片免费 | 免费观看国产网址你懂的 | 欧美日韩高清一区二区三区 | 综合久久国产九一剧情麻豆 | 亚洲A∨无码精品午夜电影 高清欧美在线三级视频 | 国产放荡AV剧情演绎麻豆 | 成年免费视频播放网站推荐 | 中文字幕一级毛片无码视频 | 国产不卡高清在线观看视频 | 99精品久久久久久久婷婷 | 日韩免费中文字幕 | 少妇野外一级内射婬片免费放 | 澳门一级毛片手机在线看 | 国产AV无码一二三区天堂 |