亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
人妻少妇精品无码专区二区,免费可以看黄的视频s色,a级高清观看视频在线看
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-UBXD2/PE-Cy5 Conjugated antibody (bs-11675R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-11675R-PE-Cy5
英文名稱 Rabbit Anti-UBXD2/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標記的UBX結(jié)構(gòu)域域蛋白D2抗體
別    名 Erasin; FLJ23318; KIAA0242; KIAA2042; UBX domain containing 1; UBX domain containing 2; UBX domain containing protein 2; UBXD 2; UBXDC 1; UBXDC1; UBXN4_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  Alzheimer's  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 57kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human UBXD2 (201-300aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Erasin is an endoplasmic reticulum (ER) and nuclear envelope membrane protein. Expressed in a variety of tissues, such as brain, placenta, heart, liver, prostate, kidney, pancreas, lung and skeletal muscle, erasin contains one UBX domain and participates in the clearing of ERAD (endoplasmic reticulum-associated protein degradation) substrates. The UBX domain of erasin is responsible for mediating its direct interaction with VCP (valosin-containing protein), an AAA-ATPase molecular chaperone. In response to ER stress, erasin expression is induced. The knockdown of erasin expression leads to the inhibition of ERAD, suggesting an important function of erasin in the ERAD pathway. In addition, erasin may be involved in Alzheimer’s disease, as it is known to accumulate in neurofibrillary degenerating neurons in patients with Alzheimer’s disease.

Function:
UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP) and promotes ER-associated protein degradation (ERAD). Immunohistochemical staining of brain tissue from patients with Alzheimer's disease and control subjects revealed that UBXD2 accumulates preferentially in neurons undergoing neurofibrillary degeneration in Alzheimer's disease.

Subunit:
Directly interacts with VCP.

Subcellular Location:
Endoplasmic reticulum membrane. Both the N- and the C-terminus face the cytosol; also found in the nucleus envelope contiguous to the ER.

Tissue Specificity:
Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Contains 1 UBX domain.

Database links:

Entrez Gene: 476130 Dog

Entrez Gene: 23190 Human

Entrez Gene: 67812 Mouse

Entrez Gene: 304766 Rat

Omim: 611216 Human

SwissProt: Q92575 Human

SwissProt: Q8VCH8 Mouse

SwissProt: Q5HZY0 Rat

Unigene: 709238 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产深夜福利在线观看网站 | 欧美美女一区二区三区 | 久久精品国产亚洲AV蜜臀 | 精品国产专区91在线 | 午夜福利免费一区二区小说 | 色妞AV永久一区二区国产AV开 | 国产精品99久久久久久WWW | 欧美人与拘牲交大全O人禾 天天躁日日躁狠狠躁日日躁黑人 | 成人区人妻精品一区二区不卡视频 | 一级毛片在线播放免费观看 | 用舌头狂虐她的小豆豆 | 91麻豆成人精品国产免费网站 | 精品日本亚洲一区二区三区 | 日韩一区二区三区射精 | 国产的一级毛片最新在线直播 | 白丝校花 扒腿自慰网站 | 91久久精品国产免费一区金莲 | 国产精品久久久久精品一级APP | 中文字幕人妻无码系列第三区 | 成人H动漫精品一区二区 | 中国亚洲女人69内射少妇 | 激情综合激情五月俺也去 | JVID亚洲精品无圣光图套 | 善良娇妻在老汉跨下呻吟 | 九九热线有精品视频99 | 国产99在线视频 | 国产超碰AV人人做人人爽 | 女的被弄到高潮娇喘喷水视频 | 国产美女裸体无遮挡免费视频高潮 | 久久夜色撩人精品国产小说 | 免费一级肉体全黄毛片365看片 | 免费精品国产自产拍在线观看图片 | 美女用震蛋叫爽的视频95视频 | 蜜臀色欲AV在线播放国产日韩 | 日韩mv国产mv网站永久 | 久久狠狠亚洲综合色成人18免费网站 | 18禁裸乳无遮挡啪啪无码免费 | 国产午夜男女爽爽爽爽爽 | 91免费精品国偷自产在线不卡 | 亚洲日韩在线男人视频网站 | 中文字幕永久天天综合 |