亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
免费大片av手机看片,欧洲美女高清一级毛片
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-14-3-3 Alpha + Beta + Gamma + Delta + Epsilon/BF647 Conjugated antibody (bs-0237R-BF647)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0237R-BF647
英文名稱 Rabbit Anti-14-3-3 Alpha + Beta + Gamma + Delta + Epsilon/BF647 Conjugated antibody
中文名稱 BF647標記的14-3-3蛋白/14-3-3 α/β/γ/δ/ε亞型抗體
別    名 14 3 3 protein beta; 14 3 3 protein beta/alpha; 14 3 3 protein zeta; KCIP 1; Protein 1054; Protein kinase C inhibitor protein 1; 14 3 3 protein delta; 14 3 3 protein gamma; YWHAB; YWHAZ; 14 3 3 protein Epsilon; 1433Z_HUMAN; 14-3-3ε; 14-3-3 α; 14-3-3 β; 14-3-3 γ; 14-3-3 δ.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞凋亡  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Sheep, Fruit Fly, yeast,11)
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human 14-3-3 (201-245aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
14-3-3 are activates tyrosine and tryptophan hydroxylases in the presence of Ca (2+)/calmodulin-dependent protein kinase II, and strongly activates protein kinase C. Is probably a multifunctional regulator of the cell signaling processes mediated by both kinases. Activates the ADP-ribosyltransferase (exoS) activity of bacterial origin. 14-3-3 proteins are localized in neurons, and are axonally transported to the nerve terminals. They may be also present, at lower levels, in various other eukaryotic tissues. It belongs to the 14-3-3 family.
This antibody is reactive with 14-3-3 Alpha, Beta, Gamma, Delta, Epsilon.

Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.

Subunit:
Interacts with CDK16 and BSPRY. Interacts with WEE1 (C-terminal). Interacts with SAMSN1. Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with Thr-phosphorylated ITGB2. Interacts with BCL2L11. Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization. Interacts with GAB2 and TLK2.

Subcellular Location:
Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes.

Post-translational modifications:
The delta, brain-specific form differs from the zeta form in being phosphorylated. Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53. This phosphorylation appears to be activated by sphingosine. Phosphorylation on Thr-232; inhibits binding of RAF1.

Similarity:
Belongs to the 14-3-3 family.

Database links:

Entrez Gene: 7529 Human

Entrez Gene: 286863 Cow

Entrez Gene: 54401 Mouse

Entrez Gene: 56011 Rat

Omim: 601289 Human

SwissProt: P68250 Cow

SwissProt: P31946 Human

SwissProt: Q9CQV8 Mouse

SwissProt: P35213 Rat

Unigene: 643544 Human

Unigene: 34319 Mouse

Unigene: 485025 Mouse

Unigene: 8653 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

信號傳導(Signaling Intermediates)
14-3-3蛋白是一個涉及調(diào)節(jié)細胞凋亡、促細胞分裂信號傳導和細胞周期關(guān)卡的蛋白質(zhì)家族。它被認為是通過與絲氨酸殘基磷酸化的蛋白質(zhì)的結(jié)合介導的信號傳導中的關(guān)鍵調(diào)節(jié)物。通過與Bad(相關(guān)死亡因子)的結(jié)合, 14-3-3 蛋白由于將Bad隔離于胞液而防止了細胞凋亡。
蛋白是14-3-3家族成員。它廣泛分布于哺乳動物、兩棲類、昆蟲、植物和酵母菌的真核生物高度保守性多功能蛋白質(zhì)。
目前已知至少有16個成員。此抗體識別分子量為30-31kDa的14-3-3蛋白αβγδε亞型。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
亚洲v无码专区国产乱码一区二区 | 777久久国产精品无码专区 | 7788精品视频免费观看 | 456性欧美在钱视频 日本妇人成熟A片免费观看 | 国产亚洲午夜精品a一区二区 | 国产-第1页-浮力影院 | 100000部又湿又黄的视频 | 国产免费久久久久久久无码浪潮 | 国产裸体美女永久免费无遮挡 | 国产网址在线观看 | 久久夜色精品亚洲噜噜国产AV | 少妇性活BBBBBBBBB小说 | 欧美午夜精品一区二区三区91 | 东北美女野外bbwbbw免费 | 欧美人与动性XXXXX杂性 | 东北少妇不戴套对白第一次 | 一本一道AV一区二区三区 | 亚洲激情无码一区二区三区 | 九九在线中文字幕无码 | 国产美女视频免费观看的网站 | 国产日韩欧美一区二区综合区 | 十八岁以下禁止观看的1000个网站 | 丝袜自慰一区二区三区四区 | 国产精品爱啪在线播放 | 国产精品久久久久久久9999 | 校花系列辣h文黑人宫交 | 欧美一区二区高清 | 成全视频在线观看免费高清版 | 极品尤物喷水爆白浆呻吟小说 | 欧美A∨一区二区三区久久黄 | 国产在线91精品入口 | 国产又湿又黄又硬又刺激视频 | 99亚洲男女激情在线观看 | 国产裸体美女永久免费无遮挡 | 亚洲精品国产不卡在线观看 | 免费无遮挡无码视频在线观看洗澡 | 99精品无人区乱码1区2区3区 | 久久精品黄AA片一区二区三区 | 99久久国产精品亚洲综合看片 | 换脸国产AV一区二区三区 | 又长又大又粗又硬3p免费视频 |