亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
又粗又大的机巴好爽视频视频,内射精品无码中文字幕,777久久精品一区二区三区无码
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-alpha 1 Antitrypsin/Cy5 Conjugated antibody (bs-0096R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0096R-Cy5
英文名稱 Rabbit Anti-alpha 1 Antitrypsin/Cy5 Conjugated antibody
中文名稱 Cy5標記的α-1抗胰蛋白酶抗體
別    名 A1-Antitrypsin; Tryptase; Alpha-1-Antitrypsin; alpha 1-antitrypsin; A1A; A1AT; AAT; Alpha 1 antiproteinase; Alpha 1 protease inhibitor; alpha-1-AT; alpha1 PI; alpha1 proteinase inhibitor; Clade A (alpha 1 antiproteinase antitrypsin) member 1; MGC23330; MGC9222; PI; PI; PRO2275; Protease inhibitor 1 (anti elastase); Serpin A1; Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 1; SerpinA1; A1AT_HUMAN; Alpha-1-antitrypsin; Alpha-1 protease inhibitor; Alpha-1-antiproteinase; Serpin A1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 心血管  免疫學  新陳代謝  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, )
產(chǎn)品應用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 44kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human alpha 1 Antitrypsin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Alpha-1-antitrypsin is a protease inhibitor, deficiency of which is associated with emphysema and liver disease. The protein is encoded by a gene (PI) located on the distal long arm of chromosome 14.

Function:
Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.
Short peptide from AAT (SPAAT) is a reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE).

Subcellular Location:
Secreted.
Short peptide from AAT: Secreted, extracellular space, extracellular matrix.

Tissue Specificity:
Plasma.

Post-translational modifications:
N-glycosylated. Differential glycosylation produces a number of isoforms. N-linked glycan at Asn-107 is alternatively di-antennary, tri-antennary or tetra-antennary. The glycan at Asn-70 is di-antennary with trace amounts of tri-antennary. Glycan at Asn-271 is exclusively di-antennary. Structure of glycans at Asn-70 and Asn-271 is Hex5HexNAc4. The structure of the antennae is Neu5Ac(alpha1-6)Gal(beta1-4)GlcNAc attached to the core structure Man(alpha1-6)[Man(alpha1-3)]Man(beta1-4)GlcNAc(beta1-4)GlcNAc. Some antennae are fucosylated, which forms a Lewis-X determinant.
Proteolytic processing may yield the truncated form that ranges from Asp-30 to Lys-418.

DISEASE:
Defects in SERPINA1 are the cause of alpha-1-antitrypsin deficiency (A1ATD) [MIM:613490]. A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.

Similarity:
Belongs to the serpin family.

Database links:

Entrez Gene: 5265 Human

Entrez Gene: 24648 Rat

Omim: 107400 Human

SwissProt: P01009 Human

SwissProt: P07758 Mouse

SwissProt: P17475 Rat

Unigene: 525557 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

α1-抗胰蛋白酶(A1AT)缺乏是最常見的遺傳代謝病,能引起肺和肝的損傷。α1抗胰蛋白酶為呼吸系統(tǒng)的非特異性可溶因子,與呼吸道抵抗力關(guān)系密切,它可抑制多種酶的活性,包括細菌的酶,以及中性白細胞溶酶體分泌的蛋白酶、彈性蛋白酶、膠原酶、纖維蛋白溶酶和凝血酶。α1抗胰蛋白酶的缺乏與慢性阻塞性肺病的形成關(guān)系密切,因為它的缺乏,不能及時控制感染和炎癥產(chǎn)生的多種蛋白酶,而造成肺組織破壞。
α1-抗胰蛋白酶由肝細胞產(chǎn)生,是一種分子量為45-56kDa的糖蛋白,它能抑制蛋白酶、彈性蛋白酶、膠原酶等多種水解酶的活性。
AAT也是一種糖蛋白,主要用于遺傳性AAT缺乏癥和良性惡性肝腫瘤、內(nèi)胚竇瘤、組織細胞性淋巴瘤以及胰腺癌、胃癌、結(jié)腸癌等各種腫瘤的研究。此抗體與大、小鼠、狗和豬有交叉反應。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产精品香蕉在线一区二区 | 真实国产精品视频国产网 | 久久婷婷五月综合丁香人人爽 | 和上司交换娇妻在线播放 | 亚洲阿v天堂网2019无码 | 99精产国品一二三产 | 精品日产卡一卡二卡麻豆 | 日韩精品专区AV无码 | 大肉大捧一进一出视频出来呀 | 国产美女精品一区二区三区 | 欧美精品一区二区三区 | 99热成人精品国产免男男 | 丰满人妻少妇久久久久久 | 99成人在线观看 | 色欲精品国产一区二区三区AV | 东北女人一级毛片 | 性做久久久久久久久浪潮 | 717影院理论午夜伦八戒 | 日韩免费一区二区三区在线 | 国产精品久久久久久久人人看 | 少妇高潮惨叫久久久久久电影 | 国产91成人精品流白浆 | 久久91亚洲精品中文字幕 | 搡的我好爽视频在线观看 | 午夜欧美日韩精品久久久久久 | 日韩AV片无码一区二区三区不卡 | 被三个男人绑着躁我好爽视频 | 国产午夜视频在线观看720P | 91青青青国产在线观看免费2019 | 国产成人AV一区二区三区无码 | 精品蜜臀AV在线天堂 | 亚洲国产高清国产拍精品 | 日韩大片在线永久免费观看网站 | 综合欧美亚洲首页在线播放 | 亚洲中文字幕在线乱妇 | 99爱在线精品视频网站 | 国产偷窥熟女精品视频大全 | 全黄H全肉短篇禁乱NP慕浅浅 | 久久国内精品自在自线 | 欧美人妻中文字幕乱码在线 | 亚洲一区爱区精品无码 |