亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲国产精品日韩专区AV,香港三级精品三级在线专区
Rabbit Anti-CD163/PE-Cy3 Conjugated antibody (bs-2527R-PE-Cy3)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2527R-PE-Cy3
英文名稱 Rabbit Anti-CD163/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標(biāo)記的CD163抗體
別    名 Scavenger receptor cysteine-rich type 1 protein M130; CD 163; CD163 antigen; CD163 molecule; Hemoglobin Scavenger Receptor; M130; M130 antigen precursor; Macrophage associated antigen; MM130; C163A_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  細(xì)胞膜受體  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 130kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CD163
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
CD163 is a 130 kDa membrane glycoprotein. It is a member of the scavenger receptor cysteine-rich superfamily and is a receptor for the hemoglobin-haptoglobin complex. CD163 is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predominantly in the late phase of inflammation. CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes. CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone. Lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) both induce shedding of CD163 from the cell surface into plasma or cell supernatant.

Function:
Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.

Subcellular Location:
Secreted and Cell membrane. Isoform 1 and isoform 2 show a lower surface expression when expressed in cells.

Tissue Specificity:
Expressed in monocytes and mature macrophages such as Kupffer cells in the liver, red pulp macrophages in the spleen, cortical macrophages in the thymus, resident bone marrow macrophages and meningeal macrophages of the central nervous system. Expressed also in blood. Isoform 1 is the lowest abundant in the blood. Isoform 2 is the lowest abundant in the liver and the spleen. Isoform 3 is the predominant isoform detected in the blood.

Post-translational modifications:
A soluble form (sCD163) is produced by proteolytic shedding which can be induced by lipopolysaccharide, phorbol ester and Fc region of immunoglobulin gamma. This cleavage is dependent on protein kinase C and tyrosine kinases and can be blocked by protease inhibitors. The shedding is inhibited by the tissue inhibitor of metalloproteinase TIMP3, and thus probably induced by membrane-bound metalloproteinases ADAMs. Phosphorylated.

Similarity:
Contains 9 SRCR domains.

Database links:

Entrez Gene: 9332 Human

Omim: 605545 Human

SwissProt: Q86VB7 Human

Unigene: 504641 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CD163是SRCR超家族成員之一,又稱為血紅蛋白清道夫受體(hemoglobin scavenger receptor, HbSR)、M130或p155。CD163的表達(dá)水平受很多因素調(diào)節(jié),糖皮質(zhì)激素及抗炎介質(zhì)如IL-10以及IL-6能上調(diào)CD163, 而促炎介質(zhì)如脂多糖(lipopolysaccharide, LPS)、γ-干擾素(interferon-γ, IFN-γ)以及TNF-α則抑制CD163表達(dá)。 CD163是一種I型膜蛋白,又稱為M130抗原、Ber-Mac3、Ki-M8或SM4。CD163限制性表達(dá)于單核/巨噬細(xì)胞系,所有循環(huán)系統(tǒng)的單核細(xì)胞和大多數(shù)組織(除外淋巴濾泡套區(qū)和生發(fā)中心)的巨噬細(xì)胞均陽(yáng)性表達(dá),主要用于單核/巨噬細(xì)胞的檢測(cè)。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
久久国产亚洲电影天堂 | 中文字幕色综合久久 | 亚洲无人区码一二三码区别图片 | 人妻内射一区二区在线视频 | 欧美人妻少妇精品视频专区 | 香蕉视频免费在线观看 | 性色AV一区二区三区咪爱四虎 | 青草国产精品久久久久久 | 国产免费久久久久久久无码浪潮 | 国产乱精品自在线免费 | 日本不卡高字幕在线2019 | 伊人一本到本勒蕉在线 | 国产主播福利一区二区 | 无码的免费不卡毛片视频 | 午夜dv内射一区二区 | 教室啪啪高挑长腿正在播放 | 国产精品污WWW在线观看 | 丰满护士巨好爽好大乳小说 | 久久精品亚洲精品无码 | 污污又黄又爽免费的网站 | 国产精品亚洲精品专区 | 精品欧美一区二区三区成人片在线 | 特级毛片A级毛片免费观看网站 | 国产真实露脸3p视频观看 | 日韩一区二区三区视频在线观看 | 少妇久久久久久被弄高潮 | 日韩青草青草久热精品视频在线网站乱码 | 女人被狂躁到爽动态gif图 | 男人的天堂无码Av色偷偷 | 亚洲专区无码天堂中文字幕 | 九九视频免费精品视频免费 | 中文字幕日本最新乱码视频 | 毛片线看免费观看 | 噜噜色青草久久丁香伊人 | 国产真实老熟女无套内射 | 又硬又粗又大一区二区三区视频 | 色欲久久久久久综合网精品 | 少妇被又大又粗又爽毛片久久黑人 | 91人妻无码精品一区二区毛片 | 亚洲AV鲁丝一区二区三区 | 欧美一区二区影院 |