亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
性满足BBWBBWBBW,免费无码又爽又黄又刺激网站
Rabbit Anti-IL33/RBITC Conjugated antibody (bs-2208R-RBITC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2208R-RBITC
英文名稱 Rabbit Anti-IL33/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的白介素33抗體
別    名 IL-33; Interleukin-33/Nuclear factor from high endothelial venules; IL33; C9orf26; CHROMOSOME 9 OPEN READING FRAME 26; DKFZp586H0523; DVS27; DVS27 related protein; IL 1F11; IL 33; IL1F11; Interleukin 1 family member 11; Interleukin 33; INTERLEUKIN 33 NFHEV; Interleukin 33 precursor; Interleukin33; NF HEV; NFEHEV; NFHEV; Nuclear factor from high endothelial venules; RP11 575C20.2 IL33_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 心血管  免疫學(xué)  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, 
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 31kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IL-33 Propeptide
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
IL33 is a cytokine which belongs to the IL-1 superfamily, and it induces helper T cells to produce type 2 cytokines. This cytokine was previously named NF-HEV 'nuclear factor (NF) in high endothelial venules' (HEVs), as it was originally identified in these specialized cells.
IL33 mediates its biological effects by interacting with the receptors ST2 and IL-1 Receptor Accessory Protein, activating intracellular molecules in the NF-kappaB and MAP kinase signaling pathways that drive production of type 2 cytokines (e.g. IL-4, IL-5 and IL-13) from polarized Th2 cells. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the the severe pathological changes observed in mucosal organs following administration of IL33.

Function:
Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Acts as a chemoattractant tor Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury.
In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation.

Subunit:
Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor IL1RAP.

Subcellular Location:
Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle. Secreted. Note=Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent.

Tissue Specificity:
Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.

Post-translational modifications:
Proteolytically converted to a mature form by CASP1 in vitro and calpains in vivo. Caspase-mediated proteolysis, once thought to activate IL33, rather acts as a switch to dampen its activity. Cathepsin G and elastase can cleave IL33 and generate highly active forms in activated neutrophils (IL-33(95-270), IL-33(99-270) and IL-33(109-270)). Proteolysis is not strictly required for biological activity.

Similarity:
Belongs to the IL-1 family. Highly divergent.

Database links:

Entrez Gene: 90865 Human

Entrez Gene: 77125 Mouse

Omim: 608678 Human

SwissProt: O95760 Human

SwissProt: Q8BVZ5 Mouse

Unigene: 731660 Human

Unigene: 182359 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
五月丁香综合缴情六月 | 亚洲欧洲国产综合AV无码久久 | 日韩成人大屁股内射喷水 | 国产精品久久综合桃花网 | 久久久精品天堂无码中文字幕 | 久久婷婷国产剧情内射白浆 | 欧美疯狂做受xxxxx喷水 | 国产无码三级片网址? | 456亚洲人成在线播放网站 | 国模超大尺度私拍 | 日产乱码一区二区三区在线 | 日本xXXx色视频在线播放 | 视频完整版午夜达达兔影院 | 精品动漫一区二区无遮挡 | 久久WWW免费人成一看片 | 免费欧美黄色网址 | 国产精品手机在线无码援交 | 美女极度色诱图片www视频 | 玩白嫩少妇小泬高潮18P | 最近中文字幕完整视频大全 | 国产精品亚洲成人久久免费看 | 色欲精品久久人妻av中文字幕 | 一级黄色毛片播放 | 久久久99精品免费观看 | 真实的国产乱xxxx在线 | 欧美影视一区二区三区 | 日韩超碰人人爽人人做人人天 | 在线免费观看日韩视频 | 最近中文字幕在线中文视频 | 亚洲一区二区三区乱码在线欧洲 | 日韩亚洲人成网站在线播放 | 欧洲亚洲日韩中文字幕首页 | 亚洲欧洲性色精品一区二区三区在线观看 | 一级特黄大片欧美久久久久久 | 91久久久久久亚洲精品蜜桃 | 国产情侣2020免费视频 | 欧美国产一区二区三区激情无套 | 日韩内射美女片在线观看网站 | 欧美乱妇狂野欧美在线视频 | 好大好深别停视频视频 | 10000部拍拍拍免费视频 |