亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
公翁搡一晚上两次,无码中文字幕拍偷乱偷精品,97久精品国产片一区二区三区
Rabbit Anti-DDB2/Cy5 Conjugated antibody (bs-2599R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2599R-Cy5
英文名稱 Rabbit Anti-DDB2/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的DNA損傷結(jié)合蛋白2抗體
別    名 damage-specific DNA binding protein 2; Damage-specific DNA-binding protein 2; DDB p48 subunit; Ddb2; DDB2_HUMAN; DDBb; DNA damage-binding protein 2; UV-damaged DNA-binding protein 2; UV-DDB 2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  染色質(zhì)和核信號  轉(zhuǎn)錄調(diào)節(jié)因子  結(jié)合蛋白  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 48kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human DDB2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq].

Function:
Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA repair.

Subunit:
Component of the UV-DDB complex which includes DDB1 and DDB2. The UV-DDB complex interacts with monoubiquitinated histone H2A and binds to XPC via the DDB2 subunit. Component of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1), which includes CUL4A or CUL4B, DDB1, DDB2 and RBX1. DDB2 may function as the substrate recognition module within this complex. The DDB1-CUL4-ROC1 complex may associate with the COP9 signalosome, and this inhibits the E3 ubiquitin-protein ligase activity of the complex. A large number of other DCX complexes may also exist in which an alternate substrate targeting subunit replaces DDB2. These targeting subunits are generally known as DCAF (DDB1- and CUL4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Isoform D1 and isoform D2 do not interact with DDB1.

Subcellular Location:
Nucleus. Note=Accumulates at sites of DNA damage following UV irradiation.

Tissue Specificity:
Ubiquitously expressed; with highest levels in corneal endothelium and lowest levels in brain. Isoform D1 is highly expressed in brain and heart. Isoform D2, isoform D3 and isoform D4 are weakly expressed.

Post-translational modifications:
Phosphorylation by ABL1 negatively regulate UV-DDB activity (By similarity).
Ubiquitinated by CUL4A in response to UV irradiation. Ubiquitination appears to both impair DNA-binding and promotes ubiquitin-dependent proteolysis. Degradation of DDB2 at sites of DNA damage may be a prerequisite for their recognition by XPC and subsequent repair. CUL4A-mediated degradation appears to be promoted by ABL1.

DISEASE:
Xeroderma pigmentosum complementation group E (XP-E) [MIM:278740]: An autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. The skin develops marked freckling and other pigmentation abnormalities. XP-E patients show a mild phenotype with minimal or no neurologic features. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the WD repeat DDB2/WDR76 family.
Contains 7 WD repeats.

Database links:

Entrez Gene: 519357 Cow

Entrez Gene: 1643 Human

Entrez Gene: 107986 Mouse

Omim: 600811 Human

SwissProt: Q0VBY8 Cow

SwissProt: Q92466 Human

SwissProt: Q99J79 Mouse

Unigene: 446564 Human

Unigene: 700338 Human

Unigene: 260747 Mouse

Unigene: 389334 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
久久99国产精品二区不卡 | 日韩欧美精品在线观看 | 国产91在线视频观看 | 99久久夜色精品国产亚洲 | 亚洲最大的熟女水蜜桃AV网站 | 成人片在线观看地址KK4444 | 亚洲无码AV一区二区 | 激情男女高潮射精AV免费 | 人善之交Z0OZO0D0G人善 | 九九视频免费精品视频免费 | 国产内射爽爽大片视频社区在线 | 老司机久久精品最新免费 | 亚洲AV日韩AV无码AV一区二区三区 | 国产V片在线播放免费观看大全 | 免费 无码 国产在线观 | 很很鲁很很在线视频97 | 97久精品国产片一区二区三区 | AAA日本高清在线播放免费观看 | 免费看人与动人物XXXX | 国产精品禁18久久久夂久 | 国产又色又爽又刺激在线观看 | 6080YYY午夜理论AA片 | 麻豆一区二区免费播放网站 | 最新上传免费网友自拍视频 | 亚洲国产中文美日韩欧美特级 | 日韩精品区一区二区三VR | 九九在线精品视频 | 国产精品久久久久久精品毛片 | 国产午夜福利不卡在线观看 | 大片免免费观看视频播放网站 | 中文字日产幕码三区的做法大全 | 四虎影库在线永久影院免费观看 | 欧美久久久噜久噜久久XXⅩ交 | 国产日韩欧美丝袜一区二区 | 正在播放羽月希与黑人bd在线 | 欧美最猛性xxxxx亚洲精品 | 四虎一区二区成人免费影院网址 | 久久亚洲AⅤ精品网站 | 色欲久久精品亚洲AV无码一区 | 91精品国产91久久久久久 | 99热国产在线精品99 |