亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
学生妹无套内射正在播放,强插女教师AV在线,欧美激情视频在线观看一区二区三区
Rabbit Anti-CDK6/Cy5 Conjugated antibody (bs-0568R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0568R-Cy5
英文名稱 Rabbit Anti-CDK6/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的周期素依賴性激酶6抗體
別    名 CDK 6; CDK6; Cell division protein kinase 6; Crk 2; Crk2; Cyclin dependent kinase 6; Cyclin-dependent kinase 6; MGC59692; p40; PLSTIRE; Serine/threonine-protein kinase PLSTIRE; STQTL11; CDK6_HUMAN; PLSTIRE; Serine/threonine protein kinase PLSTIRE.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  染色質(zhì)和核信號(hào)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, Cow, Horse, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CDK6 N-terminuse
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.

Function:
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.

Subunit:
Interaction with D-type G1 cyclins. Cyclin binding promotes enzyme activation by phosphorylation at Thr-177. Binds to RUNX1, CDKN2D, FBXO7 and CDKN2C/p18-INK4c. Forms a cytoplasmic complex with Hsp90/HSP90AB1 and CDC37. FBXO7-binding promotes D-type cyclin binding. Interacts with Kaposi's sarcoma herpesvirus (KSHV) V-cyclin and herpesvirus saimiri (V-cyclin/ECLF2); the CDK6/V-cyclin complex phosphorylates NPM1 and thus lead to viral reactivation by reducing viral LANA levels.

Subcellular Location:
Cytoplasm. Nucleus. Cell projection, ruffle. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus.

Tissue Specificity:
Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells.

Post-translational modifications:
Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity.

Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 1021 Human

Entrez Gene: 12571 Mouse

Entrez Gene: 114483 Rat

Omim: 603368 Human

SwissProt: Q00534 Human

SwissProt: Q64261 Mouse

Unigene: 119882 Human

Unigene: 31672 Mouse

Unigene: 389058 Mouse

Unigene: 399714 Mouse

Unigene: 162731 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Cyclin Dependent Kinase 6(CDK6)—周期素依賴性激酶6,是細(xì)胞周期在G1期向S期進(jìn)展的關(guān)鍵因素之一.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
2021国产精品视频一区 | 毛片基地看看成人免费 | 男人靠女人的免费视频 | 无码AV熟妇素人内射V在线 | 国产中文在线观看 | 一级欧美一级日韩片老司机99 | 特级做A爰片毛片免费看108 | 国产成人AV一区二区三区无码 | 国产a∨在在免费观看 | 牛牛本精品99久久精品88m | 大片免免费观看视频播放网站 | 国产婬乱a一级毛片多女 | 日韩久久精品无码一二级 | 久久久精品日本一区二区三区 | 二区久久久国产AV色 | 色欲狠狠躁天天躁无码中文字幕 | 国产亚洲精品中文带字幕21页 | 免费又黄又硬又爽大片 | 婷婷丁香五月天永久在线 | 伊人婷婷涩六月丁香七月 | 久久久久久久久久久久无码 | 国产亚洲精品女人久久久久久 | 欧美精品精品一区在线发布 | 国产精品va无码一区二区臀 | 国精品无码人妻一区二区三区 | 最近中文字幕免费高清mv视频 | 欧美日韩看看2015永久免费 | 免费看人与动人物XXXX | 97色伦图片97色伦图影院久久 | 抽插黄文NP合欢宗 | 亚洲AV无码乱码国产精品久久 | 国产人成无码视频在线1000 | 超清无码A片在线观看不卡 大乳妇女BD丰满 | 久久久国产精品综合无人区 | 亚洲一区二区免费 | 青青草99久久精品国产综合 | 精品国产刺激国语对白 | 国产在线观看片免费人成视频 | 国产激情久久久久99蜜桃小说 | 久久久久亚洲精品影视 | 成人片在线观看地址KK4444 |