亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产一区二区三区在线 ,99热国产在线精品99,四虎影视成人永久免费观看视频
Rabbit Anti-CDK6/PE-Cy5 Conjugated antibody (bs-0568R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0568R-PE-Cy5
英文名稱 Rabbit Anti-CDK6/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的周期素依賴性激酶6抗體
別    名 CDK 6; CDK6; Cell division protein kinase 6; Crk 2; Crk2; Cyclin dependent kinase 6; Cyclin-dependent kinase 6; MGC59692; p40; PLSTIRE; Serine/threonine-protein kinase PLSTIRE; STQTL11; CDK6_HUMAN; PLSTIRE; Serine/threonine protein kinase PLSTIRE.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  染色質(zhì)和核信號  信號轉(zhuǎn)導(dǎo)  細(xì)胞周期蛋白  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, Cow, Horse, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 37kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CDK6 N-terminuse
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb.

Function:
Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans.

Subunit:
Interaction with D-type G1 cyclins. Cyclin binding promotes enzyme activation by phosphorylation at Thr-177. Binds to RUNX1, CDKN2D, FBXO7 and CDKN2C/p18-INK4c. Forms a cytoplasmic complex with Hsp90/HSP90AB1 and CDC37. FBXO7-binding promotes D-type cyclin binding. Interacts with Kaposi's sarcoma herpesvirus (KSHV) V-cyclin and herpesvirus saimiri (V-cyclin/ECLF2); the CDK6/V-cyclin complex phosphorylates NPM1 and thus lead to viral reactivation by reducing viral LANA levels.

Subcellular Location:
Cytoplasm. Nucleus. Cell projection, ruffle. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus.

Tissue Specificity:
Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells.

Post-translational modifications:
Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity.

Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 1021 Human

Entrez Gene: 12571 Mouse

Entrez Gene: 114483 Rat

Omim: 603368 Human

SwissProt: Q00534 Human

SwissProt: Q64261 Mouse

Unigene: 119882 Human

Unigene: 31672 Mouse

Unigene: 389058 Mouse

Unigene: 399714 Mouse

Unigene: 162731 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Cyclin Dependent Kinase 6(CDK6)—周期素依賴性激酶6,是細(xì)胞周期在G1期向S期進(jìn)展的關(guān)鍵因素之一.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产一区内射最近更新 | 91精品国产色综合久久不卡美美 | 91精品欧美一区二区三区 | 性妇WBBBB搡BBBB嗓小说 | se01在线看片 | 人妻少妇看AA片偷人精品视频 | 免费的很污的很黄的网站 | 一级黄色网站在线观看 | 青青草原免费在线视频 | 国产V片在线播放免费无码 日韩在线视频一区二区三区 | 特级毛片全部免费播放免下载 | 国产精品国产馆在线真实露脸 | 天堂网在线最新版www资源网 | 小宝极品内射国产在线 | A级国产乱理伦片在线观看 国产一区二区三区影院 | 国产91在线高潮白浆在线观看 | 国产精品91在线播放久 | 国产AVXXXX无套内射 | 国产成人手机高清在线观看网站 | 色久综合网精品一区二区 | 国产午夜精品一区二区三区软件 | 亚洲色大成网站WWW永久 | 国产2021中文天码字幕 | 国产欧美日韩高清在线不卡 | 国产一级一片免费播放i | 久久久久久亚洲综合网站 | 四虎国产精品永久地址入口 | 亚洲国产成人久久综合一区77 | 欧美三级片a片在线观看 | 日韩视频在线观看 | 粗大猛烈进出高潮视频大全 | 香蕉一本大道中文在线 | 拍国产真实乱人偷精品 | 内射无码AV-区二区三区 | 中文字幕在线观看亚洲日韩 | 亚洲mv大片欧洲mv大片免费 | 人妻人人澡人人爽人人精品 | 国产 浪潮AV性色四虎 | 国产在线观看片免费人成视频 | 免费成人在线观看 | 国产熟女真实乱精品91 |