亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
中文字幕一区二区人妻性色,亚洲色欲国产综合久久天堂
Rabbit Anti-LIMK1/PE Conjugated antibody (bs-2775R-PE)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-2775R-PE
英文名稱 Rabbit Anti-LIMK1/PE Conjugated antibody
中文名稱 PE標(biāo)記的單絲氨酸蛋白激酶1抗體
別    名 EC 2.7.11.1; LIM domain kinase 1; LIM motif-containing protein kinase; LIMK; LIMK-1; LIMK2; LIMK-2; LIM domain kinase 2; LIMK1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  激酶和磷酸酶  表觀遺傳學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse, Rat,  (predicted: Human, Cow, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 71kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LIMK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
LIMK1 is a protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. LIMK1 may be involved in brain development; it is highly expressed in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.

Function:
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes.

Subunit:
Interacts (via LIM domain) with the cytoplasmic domain of NRG1. Interacts with NISCH. Interacts with RLIM and RNF6. Self-associates to form homodimers. Interacts with HSP90AA1; this interaction promotes LIMK1 dimerization and subsequent transphosphorylation. Interacts with CDN1C. Interacts with SSH1. Interacts with ROCK1.

Subcellular Location:
Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm.

Tissue Specificity:
Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.

Post-translational modifications:
Autophosphorylated. Phosphorylated on Thr-508 by ROCK1 and PAK1, resulting in activation. Phosphorylated by PAK4 which increases the ability of LIMK1 to phosphorylate cofilin. Phosphorylated at Ser-323 by MAPKAPK2 during activation of VEGFA-induced signaling, which results in activation of LIMK1 and promotion of actin reorganization, cell migration, and tubule formation of endothelial cells. Dephosphorylated and inactivated by SSH1. Phosphorylated by CDC42BP.
Ubiquitinated. 'Lys-48'-linked polyubiquitination by RNF6 leads to proteasomal degradation through the 26S proteasome, modulating LIMK1 levels in the growth cone and its effect on axonal outgrowth. Also polyubiquitinated by RLIM.

DISEASE:
Note=LIMK1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 2 LIM zinc-binding domains.
Contains 1 PDZ (DHR) domain.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 3984 Human

Entrez Gene: 16885 Mouse

Entrez Gene: 65172 Rat

Omim: 601329 Human

SwissProt: P53667 Human

SwissProt: P53668 Mouse

SwissProt: P53669 Rat

Unigene: 647035 Human

Unigene: 15409 Mouse

Unigene: 11250 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

LIM激酶1(LIMkinase1,LIMK-1)是單絲氨酸蛋白激酶,LIMK-1的活化受多種機(jī)制調(diào)控,成為聯(lián)系細(xì)胞外刺激與細(xì)胞骨架穩(wěn)定性的樞紐,在多種基本的生物學(xué)過(guò)程中起重要作用。LIMK-1包含LIM和PDZ蛋白和蛋白相互作用區(qū)、P/S結(jié)構(gòu)域、激酶結(jié)構(gòu)域,在神經(jīng)元中呈高表達(dá)。它的主要作用是使肌動(dòng)蛋白解聚因子cofilin磷酸化和失活,從而導(dǎo)致肌動(dòng)蛋白細(xì)胞骨架的改變。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
最新欧美精品二区三区 | 亚洲色欲国产综合久久天堂 | 久久久久久久国产视频 | 国语对白露脸XXXXXX | 野花高清在线观看免费 | 一级毛片在线免费播放 | 福利一区二区视频 | 亚洲AVAV天堂AV在线网爱情 | 一区国产传媒国产精品 | 久久久97精品国产一区蜜桃 | 国产欧美日韩综合一区在线播放 | 久久久精品国产亚洲成人满18免费网站 | 国产成人精品无码免费视频 | 蜜桃视频一区二区 | 亚洲视频在线观看 | 免费精品国产自产拍在线观看图片 | 国模沟沟一区二区三区 | 国产内射老熟女AAAA | 欧美日本韩国一二区视频 | 原神乳液狂飙开襟网站MIMEI | 激情欧美日韩一区二区 | 黄色网址视频在线播放 | 特黄三级又爽又粗又大 | 久久久91精品国产一区二区 | 探花口爆颜射乳交日韩 | 精品国产午夜肉伦伦影院 | 91精品国产91久久久久久 | 国产精品三级在线观看 | 爆乳3把你榨干哦OVA在线观看 | 国产精品污WWW在线观看 | 永久免费精品精品永久-夜色 | 国产精品久久国产三级国电话系列 | 欧美日韩永久久一区二区三区 | 亚洲乱码国产乱码精品精乡村 | 91大神在线观看视频 | 色欲午夜无码久久久久久 | 亚洲A∨无码精品午夜电影 高清欧美在线三级视频 | 91嫖妓站街按摩店老熟女 | 欧美人与禽x0x0牲伦交 | 100000部又湿又黄的视频 | 熟妇人妻久久中文字幕麻豆网 |