亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
国产精品禁18久久久夂久,13小箩利无码视频网站免费
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-LIMK1/BF594 Conjugated antibody (bs-2775R-BF594)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2775R-BF594
英文名稱 Rabbit Anti-LIMK1/BF594 Conjugated antibody
中文名稱 BF594標記的單絲氨酸蛋白激酶1抗體
別    名 EC 2.7.11.1; LIM domain kinase 1; LIM motif-containing protein kinase; LIMK; LIMK-1; LIMK2; LIMK-2; LIM domain kinase 2; LIMK1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  細胞生物  神經(jīng)生物學  信號轉導  激酶和磷酸酶  表觀遺傳學  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Mouse, Rat,  (predicted: Human, Cow, Rabbit, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 71kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human LIMK1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
LIMK1 is a protein kinase which regulates actin filament dynamics. Phosphorylates and inactivates the actin binding/depolymerizing factor cofilin, thereby stabilizing the actin cytoskeleton. LIMK1 may be involved in brain development; it is highly expressed in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.

Function:
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes.

Subunit:
Interacts (via LIM domain) with the cytoplasmic domain of NRG1. Interacts with NISCH. Interacts with RLIM and RNF6. Self-associates to form homodimers. Interacts with HSP90AA1; this interaction promotes LIMK1 dimerization and subsequent transphosphorylation. Interacts with CDN1C. Interacts with SSH1. Interacts with ROCK1.

Subcellular Location:
Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm.

Tissue Specificity:
Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.

Post-translational modifications:
Autophosphorylated. Phosphorylated on Thr-508 by ROCK1 and PAK1, resulting in activation. Phosphorylated by PAK4 which increases the ability of LIMK1 to phosphorylate cofilin. Phosphorylated at Ser-323 by MAPKAPK2 during activation of VEGFA-induced signaling, which results in activation of LIMK1 and promotion of actin reorganization, cell migration, and tubule formation of endothelial cells. Dephosphorylated and inactivated by SSH1. Phosphorylated by CDC42BP.
Ubiquitinated. 'Lys-48'-linked polyubiquitination by RNF6 leads to proteasomal degradation through the 26S proteasome, modulating LIMK1 levels in the growth cone and its effect on axonal outgrowth. Also polyubiquitinated by RLIM.

DISEASE:
Note=LIMK1 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Contains 2 LIM zinc-binding domains.
Contains 1 PDZ (DHR) domain.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 3984 Human

Entrez Gene: 16885 Mouse

Entrez Gene: 65172 Rat

Omim: 601329 Human

SwissProt: P53667 Human

SwissProt: P53668 Mouse

SwissProt: P53669 Rat

Unigene: 647035 Human

Unigene: 15409 Mouse

Unigene: 11250 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

LIM激酶1(LIMkinase1,LIMK-1)是單絲氨酸蛋白激酶,LIMK-1的活化受多種機制調(diào)控,成為聯(lián)系細胞外刺激與細胞骨架穩(wěn)定性的樞紐,在多種基本的生物學過程中起重要作用。LIMK-1包含LIM和PDZ蛋白和蛋白相互作用區(qū)、P/S結構域、激酶結構域,在神經(jīng)元中呈高表達。它的主要作用是使肌動蛋白解聚因子cofilin磷酸化和失活,從而導致肌動蛋白細胞骨架的改變。
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
婷婷伊人久久大香线蕉AV | 中文天堂在线WWW最新版官网 | a级毛片黄免费a级毛片 | 国产免费久久精品99re丫y | 天堂网在线最新版www | 久久永久免费视频 | 国产一区二区在线视频 | 欧美乱码精品一区二区三区卡 | 国产的一级毛片最新在线直播 | 粉嫩国产15xxxxx | 欧美性猛交XXXX乱大交极品 | 亚洲A∨无码精品午夜电影 高清欧美在线三级视频 | 老司机无码精品A | 91人妻无码精品一区二区毛片 | 黄色三级网站免费 | 国产精品免费一级在线观看 | 女帝被扒开双腿疯狂输出 | 人妻欧美精品AAAAAAAAA片 | 40岁成熟女人牲交片 | 免费在线视频一区 | WW欧日韩视频高清在线 | 国产精品白浆无码流出.在线观看 | 欧美日韩国产码综合一区在线 | 狠狠CAO日日穞夜夜穞 | 蜜桃羞羞小视频在线观看 | 精品亚洲国产成AV人片传媒 | 爱情岛网站亚洲禁18进入 | 国产精品99久久久精品无码 | 日本乱子人伦在线视频 | 亚洲精品99久久久久中文字幕 | 亚洲成av人影院 | 五月天婷亚洲天综合网 | 国产成人精选视频在线观看不卡 | H女主从小被C到大荤话小说 | 色一情一交一乱一区二区三区 | 亚洲一区二区免费 | 国产成人无码精品久久久APP | 国产微拍一区二区三区四区 | 成人免费视频一区 | 亚洲无线一二三四区手机 | 国产午夜亚洲精品国产 |