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Rabbit Anti-Phospho-HSP90 alpha (Thr5 + Thr7)/BF594 Conjugated antibody (bs-3181R-BF594)
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3181R-BF594
英文名稱(chēng) Rabbit Anti-Phospho-HSP90 alpha (Thr5 + Thr7)/BF594 Conjugated antibody
中文名稱(chēng) BF594標(biāo)記的磷酸化熱休克蛋白90α抗體
別    名 HSP90 alpha (Phospho-Thr5/7); HS90A_HUMAN; heat shock 90kDa protein 1 alpha; Heat shock protein 90kDa alpha cytosolic class A member 1; heat shock protein 90kDa alpha (cytosolic), class A member 2; Heat shock protein 90kDa alpha cytosolic class B member 1; Heat shock protein HSP 90 alpha; Heat shock protein HSP 90-alpha; Heat shock protein HSP 90 beta; HSP 84; HSP 86; Hsp 90; HSP84; HSP86; Hsp89; HSP89A; Hsp90; HSP90 Beta; HSP90A; HSP90AA1; HSP90AB1; HSP90B; HSP90N; HSPC1; HSPC2; HSPCA; HSPCAL1; HSPCAL3; HSPCAL4; HSPCB; HSPN; Heat shock 86 kDa; HSP90ALPHA; HSPN; LAP2; Lipopolysaccharide associated protein2; LPS associated protein 2; NY REN 38 antigen; Renal carcinoma antigen NY REN 38; Renal carcinoma antigen NY-REN-38; D6S182; FLJ26984; FLJ31884.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
產(chǎn)品類(lèi)型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞外基質(zhì)  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Pig, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 84kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human HSP90 around the phosphorylation site of Thr5/7
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
In mammalian cells there are at least two Hsp90 isoforms, Hsp90a and Hsp90b which are encoded by separate genes. These ubiquitous and highly conserved proteins account for 1-2% of all cellular proteins in most cells. Hsp90 is part of the cells powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by nonphysiological conditions. However, in the absence of stress, Hsp90 is a necessary component of fundamental cellular processes such as hormone signaling and cell cycle control. In this context several key regulatory proteins such as steriod receptors, cell cycle kinases involved in signal transduction and p53 have been identified as substrates of Hsp90. It has been suggested that Hsp90 acts as a capacitor for morphological evolution by buffering widespread variation, which may affect morphogenic pathways.

Function:
Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.

Subunit:
Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34. Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex. Interacts with CHORDC1 and DNAJC7. Interacts with STUB1 and UBE2N; may couple the chaperone and ubiquitination systems.

Subcellular Location:
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Post-translational modifications:
ISGylated.
S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1.

Similarity:
Belongs to the heat shock protein 90 family.

Database links:

Entrez Gene: 423463 Chicken

Entrez Gene: 281832 Cow

Entrez Gene: 3320 Human

Entrez Gene: 15519 Mouse

Entrez Gene: 397028 Pig

Entrez Gene: 299331 Rat

Omim: 140571 Human

SwissProt: P11501 Chicken

SwissProt: Q76LV2 Cow

SwissProt: P07900 Human

SwissProt: P07901 Mouse

SwissProt: O02705 Pig

SwissProt: P30946 Rabbit

SwissProt: P82995 Rat

Unigene: 525600 Human

Unigene: 700831 Human

Unigene: 1843 Mouse

Unigene: 341186 Mouse

Unigene: 119867 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

熱休克蛋白-90α主要在類(lèi)肌細(xì)胞、間質(zhì)細(xì)胞、支持細(xì)胞核及生精細(xì)胞的胞漿表達(dá); HSP-90 alpha與腫瘤的關(guān)系密切,在許多腫瘤細(xì)胞中HSP90α表達(dá)升高.
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