亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
91免费视频网站,一级做a爰片久久毛片免费陪 ,免费观看成人久久网免费观看
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-IRF3/PE-Cy5 Conjugated antibody (bs-2993R-PE-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-2993R-PE-Cy5
英文名稱 Rabbit Anti-IRF3/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標記的干擾素調(diào)節(jié)因子3
別    名 Interferon regulatory factor 3; IRF-3; IRF 3; IRF3_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IRF3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].

Function:
Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.

Subunit:
Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF7. Interacts with CREBBP. May interact with MAVS. Interacts with IKBKE and TBK1. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1 (via C-terminus); this interaction leads to the proteasome-dependent degradation of IRF3. Interacts with RBCK1. Interacts with TRIM21. Interacts with HERC5.

Subcellular Location:
Cytoplasm. Nucleus. Note=Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.

Tissue Specificity:
Expressed constitutively in a variety of tissues.

Post-translational modifications:
Constitutively phosphorylated on many serines residues. C-terminal serine/threonine cluster is phosphorylated in response of induction by IKBKE and TBK1. Ser-385 and Ser-386 may be specifically phosphorylated in response to induction. An alternate model propose that the five serine/threonine residues between 396 and 405 are phosphorylated in response to a viral infection. Phosphorylation, and subsequent activation of IRF3 is inhibited by vaccinia virus protein E3.
Ubiquitinated; ubiquitination involves RBCK1 leading to proteasomal degradation. Polyubiquitinated; ubiquitination involves TRIM21 leading to proteasomal degradation.
ISGylated by HERC5 resulting in sustained IRF3 activation and in the inhibition of IRF3 ubiquitination by disrupting PIN1 binding. The phosphorylation state of IRF3 does not alter ISGylation.

Similarity:
Belongs to the IRF family.
Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

Database links:

Entrez Gene: 3661 Human

Entrez Gene: 54131 Mouse

Omim: 603734 Human

SwissProt: Q14653 Human

SwissProt: P70671 Mouse

Unigene: 289052 Human

Unigene: 75254 Human

Unigene: 3960 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

干擾素調(diào)節(jié)因子家族是一大類對干擾素起調(diào)控作用的轉(zhuǎn)錄因子的統(tǒng)稱。 一般認為干擾素調(diào)節(jié)因子(IRF)通過調(diào)節(jié)干擾素的表達而行使其抗病毒、應(yīng)激、免疫調(diào)節(jié)功能。近年來,研究人員發(fā)現(xiàn)IRF在細胞凋亡、細胞周期、細胞分化、腫瘤發(fā)生中也起著重要的調(diào)節(jié)作用。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
人妻少妇看A偷人无码电影 亚洲AV午夜福利无码精品一区 | 国产精品久久久久三级无码 | 好吊妞视频这里有精品 | 国产精品久久久久久久人人看 | 国产v亚洲v天堂a无码 | 国产91麻豆免费观看 | 教室啪啪高挑长腿正在播放 | 欧美日韩一区精品视频一区二区 | 国产片AV不卡在线观看 | 亚洲AV无码一区二区三区在线高 | 男女激情无遮挡免费视频 | 一牛影视传媒有限公司官网 | 好爽毛片一区二区三区色欲 | 狠狠躁夜夜躁人人爽天天69 | 国产96在线视频播放网站 | 国产精品色拉拉免费看 | 久久精品免费无码一级A片 亚洲精品123区 | 一区二区三区日韩免费播放 | 日韩欧美国产丝袜大香蕉 | 天天影视色香欲综合网老头 | 精品黄毛片久久99国产 | 日本有码在线中文字幕 | 国产精品自在拍在线播放 | 少妇的奶头又大又红又涨 | 麻豆文化传媒精品1区2区3区 | 国产精品久久久精品无码 | 全黄H全肉短篇禁乱NP慕浅浅 | 婷婷五月综合缴情在线视频 | 国产精品久久久久9999小说 | 日韩经典欧美一区二区三区 | 国产欧美一区二区三区不卡 | 精品国产专区91在线 | 日韩精品免费在线观看 | 欧美亚洲性色影视在线 | 四川少扫搡BBW搡BBBB | 男男被一根又一根H强迫NP | 97亚洲熟妇自偷自拍另类图片 | 中文字幕+乱码+中文乱码www | 性夜影院爽黄A爽免费动漫 亚洲黄色一级大片 | 女性高爱潮有声视频A片 | 澳门一级特黄录像免费播黄 |