亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
蹂躏清冷仙子翘臀雪乳,www.99在线,国产第一页浮力影院草草
Rabbit Anti-Phospho-FGFR1(Tyr653 + Tyr654)/PE-Cy5.5 Conjugated antibody (bs-3205R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3205R-PE-Cy5.5
英文名稱 Rabbit Anti-Phospho-FGFR1(Tyr653 + Tyr654)/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的磷酸化堿性成纖維細(xì)胞生長因子受體1抗體
別    名 FGFR1 alpha (phospho Y654) ; FGFR1 (phospho Y653 + Y654); p-FGFR1 (phospho Y653 + Y654); bFGF R; BFGFR; C FGR; CD 331; CD331; CD331 antigen; FGF Receptor; CEK; FGFBR; FGFR 1; Fibroblast growth factor receptor 1; FLG; FLG protein; FLJ14326; FLT 2; FLT2; Fms like tyrosine kinase 2; Fms related tyrosine kinase 2; Fms related tyrosine kinase 2 Pfeiffer syndrome; H2; H3; H4; H5; HBGFR; Heparin binding growth factor receptor; Hydroxyaryl protein kinase; KAL 2; KAL2; MFR; N SAM; N sam tyrosine kinase; Protein tyrosine kinase; Tyrosylprotein kinase; Basic fibroblast growth factor receptor 1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  生長因子和激素  轉(zhuǎn)錄調(diào)節(jié)因子  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 88kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human FGFR1 around the phosphorylation site of Tyr653/654
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.

Function:
Receptor for fibroblast growth factors FGF2 and FGF1. Receptor for FGF23 in the presence of KL. Promotes mitogenesis in response to fibroblast growth factors. Activates PLCG1.

Subunit:
Homodimer. Interacts with KLB. Interacts with KL and FGF23. Interacts with SHB and GRB10. Interacts with PLCG1 (via SH2 domains). Interacts with KAL1; this interaction does not interfere with FGF2-binding to FGFR1, but prevents binding of heparin-bound FGF2. Interacts with SOX2 and SOX3.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.

Post-translational modifications:
Binding of FGF1 and heparin promotes autophosphorylation on tyrosine residues and activation of the receptor.

DISEASE:
Defects in FGFR1 are a cause of Pfeiffer syndrome (PS) [MIM:101600]; also known as acrocephalosyndactyly type V (ACS5). PS is characterized by craniosynostosis (premature fusion of the skull sutures) with deviation and enlargement of the thumbs and great toes, brachymesophalangy, with phalangeal ankylosis and a varying degree of soft tissue syndactyly.
Defects in FGFR1 are a cause of idiopathic hypogonadotropic hypogonadism (IHH) [MIM:146110]. IHH is defined as a deficiency of the pituitary secretion of follicle-stimulating hormone and luteinizing hormone, which results in the impairment of pubertal maturation and of reproductive function.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.
Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 2260 Human

Entrez Gene: 14182 Mouse

Entrez Gene: 79114 Rat

Omim: 136350 Human

SwissProt: P11362 Human

SwissProt: P16092 Mouse

SwissProt: Q04589 Rat

Unigene: 264887 Human

Unigene: 265716 Mouse

Unigene: 207203 Rat

Unigene: 9797 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

堿性成纖維細(xì)胞生長因子(bFGF)是一種多功能的生長因子,具有促進(jìn)細(xì)胞有絲分裂和誘導(dǎo)新血管形成作用,和其受體(FGFR1)堿性成纖維細(xì)胞生長因子受體結(jié)合之后,在人體各組織中具有廣泛的生物學(xué)活性和生理病理作用.越來越多的研究表明腫瘤細(xì)胞中bFGF-R1過度表達(dá)對腫瘤發(fā)生發(fā)展具有重要意義
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产成人无码区免费网站 | 欲色aV无码一区二区人妻 | 草草在线观看视频 | 色狠狠久久AV北条麻妃 | 亚洲欧美日韩国产精品一区二区 | AV 无码 高潮+喷水 | 国产高颜值大学生情侣酒店 | 久久99视频免费 | 亚洲欧美国产成人综合不卡 | 久久久精品日本一区二区三区 | 日本一上一下爱爱免费 | 日韩一级视频在线观看播放 | 精品国产aⅴ无码一区二区91 | 边做饭边被躁在线播放 | 农村女人一级毛片20岁的毛片 | 被两个两个黑人吃奶4P | 国产无吗一区二区三区在线欢 | www.99在线 | 欧美精品一区二区蜜臀亚洲 | 国产精品亚洲综合五月天 | 456亚洲人成影院在线观 | 少妇人妻AV毛片在线看 | 又大又紧又粗c死你视频 | 91精品国产高清久久久久久 | 一二三四五在线播放免费观看中文版 | 色国产在线视频一区 | 禁欲总裁被C呻吟双腿大张 亚洲欧美日韩中文久久 | 亚洲综合精品一二三区在线 | 男人天堂网在线视频观看 | 女性高爱潮AAAA级视频免费 | 国产午夜男女爽爽爽爽爽 | 国产AV电影区二区三区曰曰骚网 | 亚洲女精品一区二区三区 | 色婷五月综激情亚洲综合 | 四虎影视成人永久免费观看视频 | 热久久国产欧美一区二区精品 | 国产亚洲午夜精品a一区二区 | 日日天干夜夜狠狠爱 | 亚洲欧美日韩一本无线码专区 | 娇妻在客厅被朋友玩得呻吟漫画 | 亚洲国产18成人中文字幕久久久久无码av |