亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質(zhì)量反饋  關于我們  聯(lián)系我們
99成人在线观看,亚洲精品白浆高清久久久久久
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-Phospho-MEK7 (Ser271 + Thr275)/APC Conjugated antibody (bs-3277R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3277R-APC
英文名稱 Rabbit Anti-Phospho-MEK7 (Ser271 + Thr275)/APC Conjugated antibody
中文名稱 APC標記的磷酸化絲裂原活化蛋白激酶MKK7抗體
別    名 MEK7 (phospho S271 + T275); p-MEK7 (phospho S271 + T275); MEK7 (phospho S271 + T275); MEK7 (phospho Ser271 + Thr275); c-Jun N-terminal kinase kinase 2; Dual specificity mitogen activated protein kinase kinase 7; Dual specificity mitogen-activated protein kinase kinase 7; JNK activating kinase 2; JNK kinase 2; JNK-activating kinase 2; Jnkk 2; Jnkk-2; Jnkk2; MAP kinase kinase 7; MAP2K7; MAPK/ERK kinase 7; MAPKK 7; MAPKK-7; MAPKK7; MEK 7; Mitogen Activated Protein Kinase kinase 7; MKK 7; MKK-7; MKK7; MP2K7_HUMAN; PRKMK 7; PRKMK-7; PRKMK7; Sek 2; Sek-2; Sek2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領域 腫瘤  信號轉(zhuǎn)導  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, )
產(chǎn)品應用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human MKK7 around the phosphorylation site of Ser271/Thr275
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008].

Function:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Subunit:
Interacts with isoform 1 of VRK2. Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1. Interacts with MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Interacts with RASSF7, the interaction promotes phosphorylation.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.

Post-translational modifications:
Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks).

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 5609 Human

Entrez Gene: 26400 Mouse

Entrez Gene: 363855 Rat

Omim: 603014 Human

SwissProt: O14733 Human

SwissProt: Q8CE90 Mouse

SwissProt: Q4KSH7 Rat

Unigene: 531754 Human

Unigene: 3906 Mouse

Unigene: 162081 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
精品动漫一区二区无遮挡 | 又黄又湿免费高清视频 | 一品二品三品免费看 | a级毛片黄免费a级毛片 | 国产在线精品福利大全 | 国产精品久久久久久久久久免费 | 国产在线精品一区二区不卡顿 | 久久精品一区二区国产 | 九九热这里只有国产精品 | 久久精品中文字幕无码有码 | 国产一区二区精品久久岳 | 麻豆国产精品番甜甜七夕 | JLZZJLZZ亚洲乱熟在线播放 | 亚洲国产美女视频 | 中国少妇BBWBBW牲交 | 娇妻在客厅被朋友玩得呻吟漫画 | 中文天堂网在线最新版 | 精人妻无码一区二区三区 | 麻豆一区二区在我观看 | 亚洲日本香蕉视频观看视频 | 91系列在线观看免费 | 欧美老汉色老汉首页a亚洲 国产精品密蕾丝视频下载 久久精品亚洲精品无码 | 都市人妻古典武侠另类校园 | 狠狠色综合7777久夜色撩人 | 2020天堂在线亚洲精品专区 | 日韩特黄特色大片免费视频 | 999久久狠狠免费精品 | 亚洲精品卡2卡3卡4卡5卡区 | 亚洲欧美卡通动漫丝袜 | 99视频有精品视频在线观看 | 丝袜情趣在线资源二区 | 国产精品无码免费专区午夜 | 亚洲自偷自拍熟女另类 | **色毛片免费看 | 91精品久久久久久中文字幕 | 无套内射极品少妇CHINESE | 最近高清中文在线字幕在线观看 | 在线播放无码后入内射少妇 | 精品人妻中文字幕乱码 | 亚洲无码AV一区二区 | 2018高清国产一区二区三区 |