亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯系我們
伊人99综合精品视频,最近中文字幕完整版2018一页,成人网站在线进入爽爽爽
首頁 > 產品中心 > 標記一抗 > 產品信息
Rabbit Anti-Phospho-MEK7 (Ser271 + Thr275)/BF488 Conjugated antibody (bs-3277R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產品編號 bs-3277R-BF488
英文名稱 Rabbit Anti-Phospho-MEK7 (Ser271 + Thr275)/BF488 Conjugated antibody
中文名稱 BF488標記的磷酸化絲裂原活化蛋白激酶MKK7抗體
別    名 MEK7 (phospho S271 + T275); p-MEK7 (phospho S271 + T275); MEK7 (phospho S271 + T275); MEK7 (phospho Ser271 + Thr275); c-Jun N-terminal kinase kinase 2; Dual specificity mitogen activated protein kinase kinase 7; Dual specificity mitogen-activated protein kinase kinase 7; JNK activating kinase 2; JNK kinase 2; JNK-activating kinase 2; Jnkk 2; Jnkk-2; Jnkk2; MAP kinase kinase 7; MAP2K7; MAPK/ERK kinase 7; MAPKK 7; MAPKK-7; MAPKK7; MEK 7; Mitogen Activated Protein Kinase kinase 7; MKK 7; MKK-7; MKK7; MP2K7_HUMAN; PRKMK 7; PRKMK-7; PRKMK7; Sek 2; Sek-2; Sek2.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產品類型 磷酸化抗體 
研究領域 腫瘤  信號轉導  細胞凋亡  轉錄調節(jié)因子  激酶和磷酸酶  細胞膜受體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, )
產品應用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 47kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human MKK7 around the phosphorylation site of Ser271/Thr275
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined. [provided by RefSeq, Jul 2008].

Function:
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.

Subunit:
Interacts with isoform 1 of VRK2. Interacts (via its D domain) with its substrates MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1 and MAP3K1/MEKK1. Interacts with MAPK8IP1/JIP1, MAPK8IP2/JIP2 and MAPK8IP3/JIP3 scaffold proteins. Interacts with RASSF7, the interaction promotes phosphorylation.

Subcellular Location:
Nucleus. Cytoplasm.

Tissue Specificity:
Ubiquitous; with highest level of expression in skeletal muscle. Isoform 3 is found at low levels in placenta, fetal liver, and skeletal muscle.

Post-translational modifications:
Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks).

Similarity:
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 5609 Human

Entrez Gene: 26400 Mouse

Entrez Gene: 363855 Rat

Omim: 603014 Human

SwissProt: O14733 Human

SwissProt: Q8CE90 Mouse

SwissProt: Q4KSH7 Rat

Unigene: 531754 Human

Unigene: 3906 Mouse

Unigene: 162081 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網安備110107000727號
日本一区二区无卡高清视频 | 亚洲国产精品久久久天堂 | 国产精品原创巨作AV | 又湿又紧又大又爽又A视频 一二三四社区在线中文视频 | 亚裔美女被黑人巨大进入 | 伊人久久大香线蕉成人综合网 | 国产一级Av片在线观看 | 特级毛片全部免费播放免下载 | 亚洲高清成人AV电影网站 | 欧美日韩综合精品二区 | 风情韵味人妻HD | 欧美日韩精品一区二区在线播放蜜臀 | 最近免费中文字幕大全免费版视频 | 狠狠人妻久久久久久综合 | 青春禁区在线观看免费 | 777久久精品一区二区三区无码 | 亚洲无人区码一码二码三码四码 | 人妻人人澡人人添人人爽冫 | 高潮内射免费看片 | 久久久久Av免费无码久久 | 97精品国产高清自在线看超 | 久久人人做人人爽久久99国产乱子伦精品免 | 久久无码人妻精品一区二区三区 | 亚洲妇女熟BBW | 最美情侣高清免费观看在线 | 精品无码一区二区三区亚洲桃色 | 一二三四视频免费社区5 | 极品无码AV国模在线观看 | 中文字幕丰满乱孑伦无码专区 | 精品一区二区三区在线成人 | 久久久久久久久66精品片 | 日韩精品在线观看免费 | 国产微拍一区二区三区四区 | 日日噜噜夜夜爽爽 | 野花视频在线观看高清免费完整版 | 欧美巨鞭大战丰满少妇 | 一级毛片免费观看不卡的 | WWW夜片内射视频日韩精品成人 | 亚洲无线一二三四区手机 | 亚洲宅男精品一区在线观看 | 最近中文字幕国语免费高清6 |