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Mouse Anti-Insulin (1G11)/BF594 Conjugated antibody (bsm-0855M-BF594)
訂購(gòu)熱線:400-901-9800
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bsm-0855M-BF594
英文名稱 Mouse Anti-Insulin (1G11)/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的胰島素單克隆抗體
別    名 ILPR; INS; Insulin A chain; Insulin B chain; Insulin A chain; Insulin precursor; IRDN; Proinsulin; Proinsulin precursor; IDDM2; INS_HUMAN; MODY10.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  生長(zhǎng)因子和激素  糖尿病  內(nèi)分泌病  新陳代謝  
抗體來(lái)源 Mouse
克隆類型 Monoclonal
克 隆 號(hào) 1G11
交叉反應(yīng) (predicted: Human, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 5.8/12kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 Recombinded human Insulin protein
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Insulin is a pancreatic hormone that regulates glucose and is involved in the synthesis of protein and fat. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds.Belongs to the insulin family. The insulin-link growth factors, IGF-I and IGF-II (also desinated somatomedin C and multiplication stimulating activator, respectvely), share approximatly 76% sequence identity and are 50% related to pro-insulin.IGF-I and IGF-II are nonglycosylated, single chain proteins of 70 and 76 amino acids in length, respectivelly. IGF-I functions as an autocrine regulator of growth in vaious, whereas the function of IGF-II is less well defined.

Function:
Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

Subunit:
Heterodimer of a B chain and an A chain linked by two disulfide bonds.

Subcellular Location:
Secreted.

DISEASE:
Hyperproinsulinemia, familial (FHPRI) [MIM:176730]: An autosomal dominant condition characterized by elevated levels of serum proinsulin-like material. Note=The disease is caused by mutations affecting the gene represented in this entry.
Diabetes mellitus, insulin-dependent, 2 (IDDM2) [MIM:125852]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Note=The disease is caused by mutations affecting the gene represented in this entry.
Diabetes mellitus, permanent neonatal (PNDM) [MIM:606176]: A rare form of diabetes distinct from childhood-onset autoimmune diabetes mellitus type 1. It is characterized by insulin-requiring hyperglycemia that is diagnosed within the first months of life. Permanent neonatal diabetes requires lifelong therapy. Note=The disease is caused by mutations affecting the gene represented in this entry.
Maturity-onset diabetes of the young 10 (MODY10) [MIM:613370]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the insulin family.

Database links:

Entrez Gene: 3630 Human

Entrez Gene: 280829 Cow

Entrez Gene: 16333 Mouse

Entrez Gene: 16334 Mouse

Entrez Gene: 24505 Rat

Entrez Gene: 397415 Pig

Omim: 176730 Human

SwissProt: P01308 Human

SwissProt: P01325 Mouse

SwissProt: P01322 Rat

SwissProt: P01315 Pig

Unigene: 272259 Human




Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

胰島素(Isulin)胰島素抗體是胰島細(xì)胞分泌得一種激素,可以減底血糖濃度。此抗體和人胰島素反應(yīng),并與大多數(shù)哺乳類動(dòng)物的胰島素有交叉反應(yīng),主要用于胰島細(xì)胞瘤的功能性研究。
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