亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产综合成人久久大片,99热成人精品国产免男男,亚洲第一区欧美国产不卡综合
Rabbit Anti-Phospho-Mcl1 (Ser159 + Thr163)/Cy5 Conjugated antibody (bs-3265R-Cy5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-3265R-Cy5
英文名稱 Rabbit Anti-Phospho-Mcl1 (Ser159 + Thr163)/Cy5 Conjugated antibody
中文名稱 Cy5標(biāo)記的磷酸化髓樣細(xì)胞白血病-1抗體
別    名 Mcl1 (phospho S159/T163); Mcl1 (phospho Ser159/Thr163); p-Mcl1 (Ser159/Thr163); myeloid cell leukemia 1; myeloid cell leukemia sequence 1; MCL-1; MCL1L; MCL 1; mcl1/EAT; MGC104264; MGC1839; TM; MCL1S; EAT) Bcl 2 related protein EAT/mcl1; BCL2 related; BCL2L3; EAT; Induced myeloid leukemia cell differentiation protein Mcl 1; myeloid cell leukemia sequence 1; Myeloid cell leukemia sequence 1 BCL2 related; Myeloid cell leukemia sequence 1 isoform 1; OTTHUMP00000032794; OTTHUMP00000032795; TM; MCL1; bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES; mcl1/EAT.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  線粒體  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Cow, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 39kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthesised phosphopeptide derived from human Mcl 1 around the phosphorylation site of Ser159/Thr163
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1.

Function:
Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Subunit:
Interacts with BAD, BOK, BIK and BFM (By similarity). Interacts with PMAIP1. Isoform 1 interacts with BAX, BAK1, TPT1 and BCL2L11. Heterodimer of isoform 1 and isoform 2. Homodimers of isoform 1 or isoform 2 are not detected. Isoform 2 does not interact with pro-apoptotic BCL2-related proteins.

Subcellular Location:
Membrane; Single-pass membrane protein (Potential). Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.

Post-translational modifications:
Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.
Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region.
Phosphorylated on Thr-163. Treatment with taxol or okadaic acid induces phosphorylation on additional sites.

Similarity:
Belongs to the Bcl-2 family.

Database links:

Entrez Gene: 4170 Human

Entrez Gene: 17210 Mouse

Entrez Gene: 60430 Rat

Omim: 159552 Human

SwissProt: Q07820 Human

SwissProt: P97287 Mouse

SwissProt: Q9Z1P3 Rat

Unigene: 632486 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Mcl1蛋白是bcl-2家族成員,它在調(diào)控腫瘤細(xì)胞的凋亡、增殖、分化等過程中起一定作用。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
丁香婷婷色五月激情综合深爱 | 神马免费午夜福利剧场 | 无码不卡免费v片在线观看 国产未发育呦交视频 | 一级成人欧美一区在线观看 | 波多野结衣无码在线观看 | 人妻少妇看A偷人无码电影 亚洲AV午夜福利无码精品一区 | 国产在线观看清码视频 | 免费特黄一区二区三区视频一 | 日韩AV免费在线观看 | 四季AV无码免费专区 | 中日韩免视频上线全都免费 | 国产欧美一区二区三区久久 | 久久久久久久国产精品视频 | 久久精品中文字幕第一页国产精品 | 少妇高潮好爽在线播放 | 最新国产毛2卡3卡4卡 | 免费久久99精品国产自在现 | 美女国产毛片A区内射 | 老湿地影视体验区 | 一级a性色生活片久久无 | 无敌神马影院在线高清观看视频 | 国产美女一级做a爱视频 | 乱码一二三乱码又大又粗 | 欧美亚洲精品中文字幕乱码免费高清 | 两根大肉大捧一进一出好爽视频 | 欧美最猛性xxxxx亚洲精品 | 国产日产亚洲系列最新美 | 国产片AV片永久免费观看 | 国产黄A真人一级无码毛片一区二区三区 | 国产一级 级内射视频 | 久久狠狠亚洲综合色成人18免费网站 | 最新日韩欧美不卡一二三区 | 国产AV麻豆mag剧集 | 国产精品视频全国免费观看 | 日本中文字幕乱码免费 | 在线观看无码的免费网站 | 五十路一区二区三区视频 | 成人AV综合在线网站 | 色国产精品一区在线观看 | 日韩人妻少妇一区二区三区 | 欧美日韩视频在线视频二区 |