亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
人妻精品久久久久中文字幕一冢本,国产看黄网站又黄又爽又色,欧美牲交A欧美牲交VDO
Rabbit Anti-Cytokeratin 1/RBITC Conjugated antibody (bs-1244R-RBITC)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-1244R-RBITC
英文名稱 Rabbit Anti-Cytokeratin 1/RBITC Conjugated antibody
中文名稱 羅丹明(RBITC)標(biāo)記的細(xì)胞角蛋白1抗體
別    名 Cytokeratin 1; 67 kDa cytokeratin; CK 1; CK1; Cytokeratin1; EHK1; Hair alpha protein; K 1; K1; Keratin 1; Keratin type II cytoskeletal 1; Keratin1; KRT 1; KRT1A; K2C1_HUMAN; Keratin, type II cytoskeletal 1; Cytokeratin-1; CK-1; Keratin-1; Type-II keratin Kb1.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 腫瘤  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rabbit,  (predicted: Rat, Dog, Cow, Horse, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 70kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cytokeratin 1
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq].

Function:
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK.

Subunit:
Heterotetramer of two type I and two type II keratins. Keratin-1 is generally associated with keratin-10. Interacts with ITGB1 in the presence of GNB2L1 and SRC, and with GNB2L1. Interacts with C1QBP; the association represents a cell surface kininogen receptor.

Subcellular Location:
Cell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells.

Tissue Specificity:
The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.

Post-translational modifications:
Undergoes deimination of some arginine residues (citrullination).

DISEASE:
Defects in KRT1 are a cause of epidermolytic hyperkeratosis (EHK) [MIM:113800]. An autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
Defects in KRT1 are the cause of ichthyosis hystrix Curth-Macklin type (IHCM) [MIM:146590]. IHCM is a genodermatosis with severe verrucous hyperkeratosis. Affected individuals manifest congenital verrucous black scale on the scalp, neck, and limbs with truncal erythema, palmoplantar keratoderma and keratoses on the lips, ears, nipples and buttocks.
Defects in KRT1 are a cause of palmoplantar keratoderma non-epidermolytic (NEPPK) [MIM:600962]. NEPKK is a dermatological disorder characterized by focal palmoplantar keratoderma with oral, genital, and follicular lesions.
Defects in KRT1 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
Defects in KRT1 are the cause of palmoplantar keratoderma striate type 3 (SPPK3) [MIM:607654]; also known as keratosis palmoplantaris striata III. SPPK3 is a dermatological disorder affecting palm and sole skin where stratum corneum and epidermal layers are thickened. There is no involvement of non-palmoplantar skin, and both hair and nails are normal.

Similarity:
Belongs to the intermediate filament family.

Database links:

Entrez Gene: 3848 Human

Entrez Gene: 16678 Mouse

Entrez Gene: 300250 Rat

Omim: 139350 Human

SwissProt: P04264 Human

SwissProt: P04104 Mouse

SwissProt: Q6IMF3 Rat

Unigene: 80828 Human

Unigene: 183137 Mouse

Unigene: 31789 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

結(jié)構(gòu)蛋白(Structural Proteins)
細(xì)胞角蛋白常用于腫瘤細(xì)胞的分化、增殖及轉(zhuǎn)移方面的研究。有學(xué)者認(rèn)為:在腫瘤細(xì)胞分化過程中有細(xì)胞角蛋白的表達(dá),把細(xì)胞角蛋白作為腫瘤干細(xì)胞的標(biāo)志物。陽性部位:主要在胞漿。CK119, CK8, CK19同源.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
国产日韩欧美丝袜一区二区 | 内射后入蘑菇视频ONLYYOU | 狼人大香伊蕉国产WWW亚洲 | 欧美精品一本久久男人的天堂 | 成人国产精品一级毛片视频 | 国模冰莲2013肥美人体自慰w | 欧美性猛交AAAA片黑人 | 国产看黄网站又黄又爽又色 | 欧美日韩国产码综合一区在线 | 四川小少妇BBAABBAA | 永久黄网站色视频免费 | 完全着衣の爆乳お姉さんが | 日韩亚洲人成在线 | 一区二区三区无码成人无码 | 波多野结衣av免费观看 | 囯产精品一区二区三区线 | 日韩电影免费在线观看网站 | www.高潮原创av | 超碰高清人人爽久久人人 | 内射精品无码中文字幕 | 午夜DV内射一区区 | 少妇被躁爽到高潮无码文 | 极品无码AV国模在线观看 | 无遮挡国产高潮视频免费观看 | 欧美一级毛片在播放免费 | 麻豆传播媒体免费版官网 | 午夜亚洲WWW湿好大 欧美又大又粗又硬又色A片 | 国产精品丰满无码理论片 | 亚洲AV中文无码字幕色三 | 婷婷六月激情综合一区 | 色豆豆永久免费网站 | 亚洲中文字幕永久在线不卡 | 九九精品视频在线观看 | 少妇爆乳无码av无码专区在 | 国产乱人伦AV麻豆网 | 久久久久久久精品一区二区三区 | 国产精品污WWW在线观看 | 国产V片在线播放免费观看大全 | 手机在线毛片免费播放 | 精品无码久久久久久久久 | 国产不卡视频在线播放 |