亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
又小又紧女MAGNET ,男女性潮高片无遮挡禁18,特黄三级又爽又粗又大洗澡
Rabbit Anti-Cytokeratin 1/PE-Cy5.5 Conjugated antibody (bs-1244R-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1244R-PE-Cy5.5
英文名稱 Rabbit Anti-Cytokeratin 1/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標(biāo)記的細胞角蛋白1抗體
別    名 Cytokeratin 1; 67 kDa cytokeratin; CK 1; CK1; Cytokeratin1; EHK1; Hair alpha protein; K 1; K1; Keratin 1; Keratin type II cytoskeletal 1; Keratin1; KRT 1; KRT1A; K2C1_HUMAN; Keratin, type II cytoskeletal 1; Cytokeratin-1; CK-1; Keratin-1; Type-II keratin Kb1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  信號轉(zhuǎn)導(dǎo)  干細胞  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rabbit,  (predicted: Rat, Dog, Cow, Horse, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 70kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cytokeratin 1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq].

Function:
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinty receptor for kininogen-1/HMWK.

Subunit:
Heterotetramer of two type I and two type II keratins. Keratin-1 is generally associated with keratin-10. Interacts with ITGB1 in the presence of GNB2L1 and SRC, and with GNB2L1. Interacts with C1QBP; the association represents a cell surface kininogen receptor.

Subcellular Location:
Cell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells.

Tissue Specificity:
The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis.

Post-translational modifications:
Undergoes deimination of some arginine residues (citrullination).

DISEASE:
Defects in KRT1 are a cause of epidermolytic hyperkeratosis (EHK) [MIM:113800]. An autosomal dominant skin disorder characterized by widespread blistering and an ichthyotic erythroderma at birth that persist into adulthood. Histologically there is a diffuse epidermolytic degeneration in the lower spinous layer of the epidermis. Within a few weeks from birth, erythroderma and blister formation diminish and hyperkeratoses develop.
Defects in KRT1 are the cause of ichthyosis hystrix Curth-Macklin type (IHCM) [MIM:146590]. IHCM is a genodermatosis with severe verrucous hyperkeratosis. Affected individuals manifest congenital verrucous black scale on the scalp, neck, and limbs with truncal erythema, palmoplantar keratoderma and keratoses on the lips, ears, nipples and buttocks.
Defects in KRT1 are a cause of palmoplantar keratoderma non-epidermolytic (NEPPK) [MIM:600962]. NEPKK is a dermatological disorder characterized by focal palmoplantar keratoderma with oral, genital, and follicular lesions.
Defects in KRT1 are a cause of ichthyosis annular epidermolytic (AEI) [MIM:607602]; also known as cyclic ichthyosis with epidermolytic hyperkeratosis. AEI is a skin disorder resembling bullous congenital ichthyosiform erythroderma. Affected individuals present with bullous ichthyosis in early childhood and hyperkeratotic lichenified plaques in the flexural areas and extensor surfaces at later ages. The feature that distinguishes AEI from BCIE is dramatic episodes of flares of annular polycyclic plaques with scale, which coalesce to involve most of the body surface and can persist for several weeks or even months.
Defects in KRT1 are the cause of palmoplantar keratoderma striate type 3 (SPPK3) [MIM:607654]; also known as keratosis palmoplantaris striata III. SPPK3 is a dermatological disorder affecting palm and sole skin where stratum corneum and epidermal layers are thickened. There is no involvement of non-palmoplantar skin, and both hair and nails are normal.

Similarity:
Belongs to the intermediate filament family.

Database links:

Entrez Gene: 3848 Human

Entrez Gene: 16678 Mouse

Entrez Gene: 300250 Rat

Omim: 139350 Human

SwissProt: P04264 Human

SwissProt: P04104 Mouse

SwissProt: Q6IMF3 Rat

Unigene: 80828 Human

Unigene: 183137 Mouse

Unigene: 31789 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

結(jié)構(gòu)蛋白(Structural Proteins)
細胞角蛋白常用于腫瘤細胞的分化、增殖及轉(zhuǎn)移方面的研究。有學(xué)者認(rèn)為:在腫瘤細胞分化過程中有細胞角蛋白的表達,把細胞角蛋白作為腫瘤干細胞的標(biāo)志物。陽性部位:主要在胞漿。CK119, CK8, CK19同源.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
久久狠狠色噜噜狠狠狠狠97 | 国产午夜人做人免费视频APP | 四虎影视永久免费观看 | 国产欧美日韩一区二区搜索 | 少妇人妻上班偷人精品免费 | 九九线精品视频在线观看视频 | 国产手机在线视频 | 波多野结衣无码在线观看 | 婷婷久久综合九色综合伊人色 | 可以在线观看的黄色网址 | 亚州AV一级特黄大片 | 国产片AV不卡在线观看 | 国产精品沙发午睡系列990531 | 玩白嫩少妇小泬高潮18P | 丰满爆乳肉感一区二区三区 | 456性欧美在钱视频 日本妇人成熟A片免费观看 | 在线视频国产欧美另类 | 日韩欧美一及在线播放 | 东北女人啪啪ⅩXX对白 | 大香伊蕉在人线国产最新75 | AV无码久久久久不卡网站毛片 | 免费在线视频一区 | 黄色视频软件免费下载 | 一级毛片在线免费视频 | 抽插黄文NP合欢宗 | 日韩精品一区二区三区中文不卡 | 亚洲精品无人区在线观看 | 亚洲人精品亚洲人成在线 | 亚洲国产美女视频 | 国产午夜福利不卡在线观看 | 免费国产成人高清在线视频 | 人妻少妇精品久久久久久0000 | 亚洲国产成人综合久久精品 | 在线观看亚洲中文字幕 | 麻豆文化传媒精品1区2区3区 | 无码人妻精品一区二区三区千菊 | 伊人狠狠丁香婷婷综合尤物 | 国产亚洲精品精品精品 | 18禁无遮挡羞羞污污污污免费 | 亚洲一区二区三区高清AV | 国产亚洲午夜精品a一区二区 |