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Rabbit Anti-Phospho-Nur77(Ser351)/BF647 Conjugated antibody (bs-3313R-BF647)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3313R-BF647
英文名稱 Rabbit Anti-Phospho-Nur77(Ser351)/BF647 Conjugated antibody
中文名稱 BF647標(biāo)記的磷酸化孤兒核受體蛋白Nur77抗體
別    名 NR4A1(phospho S351); NUR77 (phospho S351); p-NUR77 (phospho S351); GFRP 1; GFRP; GFRP1; Growth factor inducible nuclear protein N10; Growth Factor Inducible Nuclear Protein NP10; Growth Factor Response Protein 1; Hbr1; HMR; Hormone Receptor; MGC9485; N10; N10 nuclear protein; NAK 1; NAK1; NGFIB; NP 10; NP10; NR4A1; Nuclear hormone receptor NUR/77; Nuclear Hormone Receptor TR3; Nuclear Receptor Subfamily 4 Group A Member 1; NUR77; Orphan nuclear receptor HMR; Orphan nuclear receptor NR4A1; ST 59; ST59; Steroid receptor TR3; TR 3; TR3; TR3 orphan receptor; Early response protein NAK1.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  心血管  細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  糖尿病  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Mouse,  (predicted: Human, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 66kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human Nur77 around the phosphorylation site of Ser351
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Function:
Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.

Subunit:
Binds DNA as a monomer. Interacts with GADD45GIP1.

Subcellular Location:
Nucleus.

Tissue Specificity:
Fetal muscle and adult liver, brain and thyroid.

Post-translational modifications:
Phosphorylated at Ser-351 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli.

Similarity:
Belongs to the nuclear hormone receptor family. NR4 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 3164 Human

Entrez Gene: 15370 Mouse

Entrez Gene: 79240 Rat

Omim: 139139 Human

SwissProt: P22736 Human

SwissProt: P12813 Mouse

SwissProt: P22829 Rat

Unigene: 524430 Human

Unigene: 119 Mouse

Unigene: 10000 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

孤兒核受體蛋白Nur77是早期反應(yīng)轉(zhuǎn)錄因子之一,多種刺激因子如缺氧可誘導(dǎo)其迅速表達,Nur77參與調(diào)控細(xì)胞增殖、存活、分化等過程。這類核受體是體內(nèi)廣泛分布的配體依賴性的轉(zhuǎn)錄因子,通過調(diào)控基因協(xié)調(diào)表達,在機體的生長發(fā)育、新陳代謝,細(xì)胞分化及體內(nèi)許多生長發(fā)育過程中發(fā)揮重要作用,其功能障礙將導(dǎo)致一系列疾病的發(fā)生,如;癌癥、糖尿病、肥胖、不孕不育等等。
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