亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产在线a免费观看,风流少妇又紧又爽又丰满
Rabbit Anti-Pin1/BF488 Conjugated antibody (bs-3541R-BF488)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3541R-BF488
英文名稱 Rabbit Anti-Pin1/BF488 Conjugated antibody
中文名稱 BF488標(biāo)記的肽基脯氨酞順反異構(gòu)酶Pinl抗體
別    名 DOD; NIMA interacting 1; Peptidyl prolyl cis trans isomerase NIMA interacting 1; Peptidyl prolyl cis/trans isomerase NIMA interacting; Pin 1; PPIase Pin1; Prolyl isomerase; Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1; Protein NIMA interacting 1; Rotamase Pin1; UBL 5; UBL5; PIN1_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 18kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Pin1
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Pin1 is a Peptidyl-prolyl isomerases (PPIase). Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding. Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds.
Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease. Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau. Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation. Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain. Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration.

Function:
Essential PPIase that regulates mitosis presumably byinteracting with NIMA and attenuating its mitosis-promotingactivity. Displays a preference for an acidic residue N-terminal tothe isomerized proline bond. Catalyzes pSer/Thr-Pro cis/transisomerizations. Down-regulates kinase activity of BTK. Cantransactivate multiple oncogenes and induce centrosomeamplification, chromosome instability and cell transformation.Required for the efficient dephosphorylation and recycling of RAF1after mitogen activation.

Subunit:
Interacts with STIL (By similarity). Interacts withKIF20B. Interacts with NEK6. Interacts (via WW domain) with PRKX.Interacts with BTK. Interacts (via PpiC domain) with DAPK1.Interacts with the phosphorylated form of RAF1. Interacts (via WWdomain) with ATCAY; upon NGF stimulation.

Subcellular Location:
Nucleus. Nucleus speckle. Cytoplasm.Note=Co-localizes with NEK6 in the nucleus. Mainly localized in thenucleus but phosphorylation at Ser-71 by DAPK1 results ininhibition of its nuclear localization.

Tissue Specificity:
The phosphorylated form at Ser-71 is expressedin normal breast tissue cells but not in breast cancer cells.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.Phosphorylation at Ser-71 by DAPK1 results in inhibition of itscatalytic activity, nuclear localization, and its ability to inducecentrosome amplification, chromosome instability and celltransformation.

Similarity:
Contains 1 PpiC domain.
Contains 1 WW domain.

Database links:

Entrez Gene: 5300 Human

Entrez Gene: 23988 Mouse

Entrez Gene: 298696 Rat

Omim: 601052 Human

SwissProt: Q13526 Human

SwissProt: Q9QUR7 Mouse

Unigene: 465849 Human

Unigene: 7906 Mouse

Unigene: 6291 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

肽基脯氨酞順反異構(gòu)酶Pinl,是調(diào)節(jié)細(xì)胞有絲分裂相關(guān)蛋白酶,對細(xì)胞周期運(yùn)行起著非常重要的調(diào)控作用。近年來研究表明,肽基脯氨酞順反異構(gòu)酶Pinl在多種腫瘤中過表達(dá),是多個致癌信號通路的關(guān)鍵效應(yīng)分子,可加強(qiáng)和催化多種致癌信號,使其無限放大,最終引起細(xì)胞轉(zhuǎn)化和增殖失控。因次,肽基脯氨酞順反異構(gòu)酶Pinl越來越引起人們關(guān)注,被稱為腫瘤發(fā)生發(fā)展的催化分子。 近來該蛋白用于老年癡呆研究的也日漸增多。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
麻豆果冻传媒新剧国产杜鹃 | 内射无套在线观看高清完整免费 | 久久久91精品国产一区二区 | 久久99人妻无码精品一区二区 | 教室啪啪高挑长腿正在播放 | 免费国产美女爽到喷出水来视频 | 欧美精品九九99久久在免费线 | 欧美AAAAAA级午夜福利视 | 少妇的奶头又大又红又涨 | 国产一级毛片国产 | 国产思思热视频在线观看 | 999视频在线观看 | 国产精品久久久久久久人人看 | 99国产一区二区三区亚洲一区影院午夜 | A级成人毛片免费视频 | 亚洲AV无码一区二区三区在线高 | 亚洲AV无码精品蜜桃 | 国产成人一区二区国产亚洲 | 成人小视频在线观看 | 欧美性爱一我在线级片 | 成人免费毛片内射美女APP | 欧美日韩在线精品视频二区下载 | 么公又大又硬又粗又长 | 国产xxxx99真实实拍 | mdapptv麻豆下载 | 97久久超碰极品视觉盛宴 | 久久久精品国产亚洲成人满18免费网站 | 国产又滑又嫩又白 | 伦人伦XXX国产对白 人妻精品久久久久中文字幕一冢本 | 中文在线中文资源 | 中文字幕+乱码+中文乱码www | 国产亚洲欧美日韩综合一区在线观看 | 国产无遮挡无码视频在线观看不卡 | 亚洲欧美日韩在线观看 | 日本高清VA在线播放 | 免费午夜无码18禁无码影视 | 少妇高潮一区二区三区99 | 亚洲日韩久久精品无码AV | 欧美久久一级内射wwwwww. | 欧美日韩亚洲一区二区三区在线观看 | 天天做天天摸天天爽天天爱 |