亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
伊人久久大香线蕉综合网站 ,国内大量揄拍人妻精品视频,精品国产乱子久久久久
Rabbit Anti-Phospho-SGK1 (Thr256)/Cy7 Conjugated antibody (bs-3397R-Cy7)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3397R-Cy7
英文名稱 Rabbit Anti-Phospho-SGK1 (Thr256)/Cy7 Conjugated antibody
中文名稱 Cy7標(biāo)記的磷酸化糖皮質(zhì)激素調(diào)節(jié)激酶1抗體
別    名 SGK1(Phospho Thr256); SGK1 (Phospho T256); Serine/threonine protein kinase SGK; Serine/threonine protein kinase Sgk1; Serine/threonine-protein kinase Sgk1; Serum and glucocorticoid regulated kinase; Serum/glucocorticoid regulated kinase 1; Serum/glucocorticoid regulated kinase; Serum/glucocorticoid-regulated kinase 1; SGK 1; SGK; SGK1; SGK1_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 免疫學(xué)  發(fā)育生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  干細(xì)胞  激酶和磷酸酶  細(xì)胞表面分子  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 49kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human SGK1 around the phosphorylation site of Thr256
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
SGK1 is a protein kinase that plays an important role in cellular stress response. SGK1 activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. Sustained high levels of SGK1 and activity may contribute to conditions such as hypertension and diabetic nephropathy. This protein also mediates cell survival signals, as it has been shown to phosphorylate and negatively regulate the pro apoptotic FOXO3A protein. Ser 422 is a critical site on the protein and may be involved in its activation.

Function:
Protein kinase that plays an important role in cellular stress response. Activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Mediates cell survival signals, phosphorylates and negatively regulates pro-apoptotic FOXO3A. Phosphorylates NEDD4L, which leads to its inactivation and to the subsequent activation of various channels and transporters such as ENaC, KCNA3/Kv1.3 or EAAT1. Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1.

Subunit:
Interacts with NEDD4 and NEDD4L.

Subcellular Location:
Isoform 2: Cell membrane.
Cytoplasm. Nucleus. Endoplasmic reticulum. Note=Nuclear, upon phosphorylation.

Tissue Specificity:
Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal muscle.

Post-translational modifications:
Regulated by phosphorylation. Phosphoinositide 3-kinase (PI3-kinase) pathway promotes phosphorylation at Ser-422 which in turn increases the phosphorylation of Thr-256 by PDPK1.
Ubiquitinated by NEDD4L; which promotes proteasomal degradation. Ubiquitinated by SYVN1 at the endoplasmic reticulum; which promotes rapid proteasomal degradation and maintains a high turnover rate in resting cells. Isoform 2 shows enhanced stability. Isoform 2 resistance to proteasomal degradation is mediated by the sequences within the first 120-amino acid.

Similarity:
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 6446 Human

Entrez Gene: 20393 Mouse

Entrez Gene: 29517 Rat

Omim: 602958 Human

SwissProt: O00141 Human

SwissProt: Q9WVC6 Mouse

SwissProt: Q06226 Rat

Unigene: 510078 Human

Unigene: 28405 Mouse

Unigene: 4636 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
日本爽爽爽爽爽爽在线观看免 | 天美传媒TMY0013在线观看 | 亚洲熟妇av一区二区三区色堂 | 国产高清av首播原创麻豆 | 一区二区三区国产 | 国产高清国内精品福利色噜噜 | 五月天久久无码综合AV | 最近中文字幕免费高清mv视频 | 公的大龟慢慢挺进我的体内视频 | 亚洲AV无一区二区三区 | 国产福利一区二区三区在线视频 | 亚洲成年人免费网站 | 毛片基地看看成人免费 | 么公又大又硬又粗又长 | 国产 浪潮AV性色四虎 | 成人国产一区二区精品小说 | 美女扒开内裤羞羞网站 | 国产精品视频一区二区三区不卡 | 无码中文字幕拍偷乱偷精品 | 欧美老熟妇又粗又大 | 成人免费毛片AAAAAA片 | 日本精品久久久久中文字幕 | 人妻体内射精一区二区 | 高潮毛片无遮挡高清免费视频 | 樱花草中文在线观看高清视频 | 绯色av入口一区二区三区 | 加勒比色综合久久久久久久久 | 一本久道久久综合婷婷五月 | 亚洲国产成人综合久久精品 | 亚洲一区二区免费 | 国产精品无码AV片在线专区 | 国产一级特黄aaa大片 | 国产黑丝一区二区 | 日本人爽p大片免费看 | ww久久综合久中文字幕老太婆 | 性短视频在线观看免费不卡流畅 | 午夜成人性爽爽免费视频 | 曰韩一级a片欧美一级a片 | 永久免费毛片在线播放 | 日韩欧美一中文字慕2O22 | 久久久久精品国产未满十八禁 |