亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产一级 片内射免费视频播放 ,日本韩国亚洲综合日韩欧美国产,成年女人色费视频免费
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-Dnmt3a/AP Conjugated antibody (bs-0497R-AP)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0497R-AP
英文名稱 Rabbit Anti-Dnmt3a/AP Conjugated antibody
中文名稱 堿性磷酸酶(AP)標記的DNA甲基轉(zhuǎn)移酶-3α抗體
別    名 DNA (cytosine 5 ) methyltransferase 3 alpha; DNA (cytosine 5) methyltransferase 3A; DNA cytosine methyltransferase 3A2; DNA methyltransferase 3a; DNA methyltransferase HsaIIIA; DNA MTase HsaI; DNA MTase HsaIIIA; DNMT 3a; DNMT; Dnmt3a; DNMT3A2; M HsaIIIA; M.HsaIIIA; MCMT; Methyl CpG binding domain protein 3a.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細胞生物  信號轉(zhuǎn)導(dǎo)  細胞凋亡  表觀遺傳學(xué)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Rat,  (predicted: Mouse, Cow, )
產(chǎn)品應(yīng)用 IHC-P=1:50-200 IHC-F=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 100kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Dnmt3a
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The tumor organization has the DNA methylation disorder, including and damps cancer gene high methylation DNA with the cell multiplication cycle close related cancer gene low methylation the methyl transferase (Dnmt) participation methylation the formation (is mainly Dnmt3a and Dnmt3b) and the maintenance (is mainly Dnmt1) (isoform CRA_b) (DNA methyltransferase MmuIIIA) (DNA MTase MmuIIIA)

Function:
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity.

Subunit:
Heterotetramer composed of 1 DNMT3A homodimer and 2 DNMT3L subunits (DNMT3L-DNMT3A-DNMT3A-DNMT3L). Interacts with UBC9, PIAS1 and PIAS2. Binds the ZNF238 transcriptional repressor. Interacts with SETDB1. Associates with HDAC1 through its ADD domain. Interacts with DNMT1 and DNMT3B. Interacts with the PRC2/EED-EZH2 complex. Interacts with MPHOSPH8. Interacts with histone H3 that is not methylated at 'Lys-4' (H3K4).

Subcellular Location:
Nucleus. Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin.

Tissue Specificity:
Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.

Post-translational modifications:
Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription.

Similarity:
Belongs to the C5-methyltransferase family.
Contains 1 ADD domain.
Contains 1 GATA-type zinc finger.
Contains 1 PHD-type zinc finger.
Contains 1 PWWP domain.

Database links:

Entrez Gene: 1788 Human

Entrez Gene: 13435 Mouse

Omim: 602769 Human

SwissProt: Q9Y6K1 Human

SwissProt: O88508 Mouse

Unigene: 515840 Human

Unigene: 5001 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

腫瘤組織存在DNA甲基化紊亂,包括與細胞增殖周期密切相關(guān)的癌基因低甲基化和抑癌基因高甲基化DNA甲基轉(zhuǎn)移酶(Dnmt)參與甲基化的形成(主要是Dnmt3a和Dnmt3b)和維持(主要是Dnmt1)
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产寡妇婬乱A毛片视频 | 四虎国产精品永久地址入口 | 日日摸夜夜添夜夜添视频 | 亚洲 校园 欧美 国产 另类 | 伊人久久大香线蕉亚洲五月天 | 精品无码国产AV一区二区性色 | 一级毛片女人喷潮 | 欧美日韩精品一区二区在线播放蜜臀 | 午夜欧美日韩国产福利91不卡一区二区三区 | 大桥未久加勒比女热大陆在线 | 久久狠狠亚洲综合色成人18免费网站 | A级黄韩国在线观看免费 | 中文字幕无限乱码不卡2021 | 在线播放中文字幕 | 好吊妞www在线观看免费 | AV无码久久久久久久久不卡网站 | 日韩在线视频观看免费网站 | 大尺度很黄很肉的小说 | 国产毛片久久久久久国产毛片 | 把插八插露脸对白内射 | 麻豆国产精品番甜甜七夕 | 内射一区二区精品视频在线观看 | 人人妻人人添人人爽欧美一区91 | 久久综合亚洲鲁鲁五月天欧美 | 亚洲最大日夜无码中文字幕 | 免费在线观看疯狂做受XXXX | 欧美成人另类精品乱码免费不卡播放 | BBW50老少配BBWBBW | 国产乱妇乱子视频在线播放国产 | 少妇久久久久久被弄高潮 | 国内精品久久久久久久试看 | 国产精品991TV制片厂在线观看 | 18禁美女裸体无遮挡免费观看国产 | 久久久久久久久久国产精品免费 | 国产成人无码区免费网站 | 亚洲国产精品一区二区三区在线观看 | 国产v综合v亚洲欧美大片 | 99久久国产宗和精品1上映 | 国产下药迷倒白嫩丰满美女BD | 久久久这里只有精品加勒比 | 小SAO货大JI巴CAO死你H |