亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
黄色网站在线免费观看,亚洲精品无码专区在线播放,BBB搡BBBB搡BBBB
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-Phospho-p73(Tyr99)/Biotin Conjugated antibody (bs-3717R-Bio)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3717R-Bio
英文名稱 Rabbit Anti-Phospho-p73(Tyr99)/Biotin Conjugated antibody
中文名稱 生物素標記的磷酸化P73腫瘤抑制基因抗體
別    名 p73(Phospho-Tyr99); p73 (phospho Y99); p-p73 (phospho Y99);TP73(phospho Y99); p53 like transcription factor; p53 Related Protein; p73; TP 73; TP73; Tumor Protein p73; P73_HUMAN.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
產(chǎn)品類型 磷酸化抗體 
研究領(lǐng)域 腫瘤  免疫學(xué)  信號轉(zhuǎn)導(dǎo)  細胞凋亡  轉(zhuǎn)錄調(diào)節(jié)因子  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, )
產(chǎn)品應(yīng)用 WB=1:50-200 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 70kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated Synthesised phosphopeptide derived from human p73 around the phosphorylation site of Tyr99 [SP(p-Y)AQ]
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
P73 protein is a structural and functional homologue of p53, a tumor suppressor gene. In this study, The p73 protein, p19ras, by the yeast two-hybrid screening method. Alternative splicing of the proto-oncogene H-ras pre-mRNA has led to two distinct transcripts, Ras proteins are known to be small membrane-localized guanine nucleotide-binding proteins. However, unlike other Ras proteins, p19ras is localized in the nucleus and the cytosol and its interaction with P73 protein occurred exclusively in the nucleus. Oncogenic MDM2 (mouse double minutes 2) is a known repressor of p73 transcriptional activity. In this study, when p19ras was bound to MDM2, it further inhibited the association of MDM2 to the p73 protein. Therefore, this study presents a novel pathway of Ras signaling that occurs in the nucleus, involving p19ras and p73.

Function:
Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. [COFACTOR] Binds 1 zinc ion per subunit

Subunit:
Found in a complex with p53/TP53 and CABLES1. The C-terminal oligomerization domain binds to the ABL1 tyrosine kinase SH3 domain. Interacts with HECW2. Isoform Beta interacts homotypically and with p53/TP53, whereas isoform Alpha does not. Isoform Gamma interacts homotypically and with all p73 isoforms. Isoform Delta interacts with isoform Gamma, isoform Alpha, and homotypically. Isoforms Alpha and Beta interact with HIPK2. Isoform Alpha interacts with RANBP9. Isoform Beta interacts with WWOX. Interacts (via SAM domain) with FBXO45 (via B30.2/SPRY domain). Interacts with YAP1 (phosphorylated form). Interacts with HCK (via SH3 domain); this inhibits TP73 activity and degradation.

Subcellular Location:
Nucleus. Cytoplasm. Note=Accumulates in the nucleus in response to DNA damage.

Tissue Specificity:
Expressed in striatal neurons of patients with Huntington disease (at protein level). Brain, kidney, placenta, colon, heart, liver, spleen, skeletal muscle, prostate, thymus and pancreas. Highly expressed in fetal tissue.

Post-translational modifications:
Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function.
Higher levels of phosphorylation seen in the brain from patients with Huntington disease.
Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome.

Similarity:
Belongs to the p53 family.
Contains 1 SAM (sterile alpha motif) domain.

Database links:

Entrez Gene: 7161 Human

Entrez Gene: 22062 Mouse

Entrez Gene: 362675 Rat

Omim: 601990 Human

SwissProt: O15350 Human

SwissProt: Q9JJP2 Mouse

Unigene: 697294 Human

Unigene: 706990 Human

Unigene: 78015 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

P73是p53基因家族的第一個成員p53基因是一個經(jīng)典的抑癌基因,與p53在結(jié)構(gòu)和功能方面具有很高的相似性。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
在线观看欧美人与动物性交 | 久久精品综合网人人妻 | 老熟妇高潮一区二区高清视频 | 18禁无遮挡羞羞污污污污免费 | 一本久久a久久精品免费不卡 | 久久综合给合久久狠狠狠97色 | 亚洲中文字幕AV在天堂 | 中国亚洲女人69内射少妇 | 一级二级无码电影在线观看 | 中文字幕av无码专区第一页 | 欧美牲交A欧美牲交 | 国产欧美日韩精品一区二区三区蜜桃不卡 | 亚洲精品无码av中文字幕网站 | 在线观看亚洲中文字幕 | 人妻中文字幕乱人伦在线 | 爽死你个放荡粗暴小淫货h文 | 国产日韩欧美丝袜一区二区 | 亚洲欧美国产双大乳头 | 欧美日韩视频在线视频二区 | 国产真人无遮挡作爱免费视频 | 国产亚洲精品中文带字幕21页 | 香港日本三级在线播放 | 亚洲成人一区二区 | 粉色视频在线观看完整版高清免费 | 射精区-区区三区 | 亚洲日本欧美产综合在线 | 无码纯肉国产麻豆久久 | 永久免费毛片在线播放 | **色毛片免费看 | 欧美日韩精品一区二区三区不卡 | 国产精品无码无卡A级毛片 国产午夜精品理论片小yo奈 | 国产黄A三级三级三级看三级 | 久久人人爽爽爽人久久久 | 国产精品丰满无码理论片 | 视频一区视频二区在线观看 | 小货SAO边洗澡边CAO你动漫 | 欧美精品精品一区在线发布 | 欧美午夜艳片欧美精品 | 国产无线乱码一区二三区 | 乱码视频午夜在线观看 | 国产又粗又猛又爽又黄的视频免费软件 |