亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
男女无遮挡XX00动态图120秒,精品无码国产污污污在线观看
Rabbit Anti-Cullin 4A/Cy5.5 Conjugated antibody (bs-3642R-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號 bs-3642R-Cy5.5
英文名稱 Rabbit Anti-Cullin 4A/Cy5.5 Conjugated antibody
中文名稱 Cy5.5標(biāo)記的Cullin 4a蛋白抗體
別    名 CUL 4A; CUL4A; Cul4a protein; MGC36573; MGC64071.  
規(guī)格價(jià)格 100ul/2980元 購買        大包裝/詢價(jià)
說 明 書 100ul  
研究領(lǐng)域 細(xì)胞生物  免疫學(xué)  細(xì)胞凋亡  合成與降解  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 83kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Cullin 4a(432-495aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Cullins assemble a potentially large number of ubiquitin ligases by binding to the RING protein ROC1 to catalyse polyubiquitination, as well as binding to various specificity factors to recruit substrates. Cullin 4a is an essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, cul4A serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul4A may also contribute to catalysis through positioning of the substrate and the ubiquitinconjugating enzyme. Cul4A also interacts with RNF7 and is part of a complex with TIP120A/CAND1, Cyclin E and RBX1.

Function:
Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9.

Subunit:
Component of multiple DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes that seem to consist of DDB1, CUL4A or CUL4B, RBX1 and a variable substrate recognition component which seems to belong to a protein family described as DCAF (Ddb1- and Cul4-associated factor) or CDW (CUL4-DDB1-associated WD40-repeat) proteins. Component of the CSA complex (DCX(ERCC8) complex) containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II. Component of the DCX(DET1-COP1) complex with the substrate recognition component DET1 and COP1. Component of the DCX(DDB2) complex with the substrate recognition component DDB2. Component of the DCX(DTL) complex with the putative substrate recognition component DTL. Interacts with DDB1, RBX1, RNF7, CTD1, TIP120A/CAND1, SKP2, CDKN1B, MDM2, TP53 and HOXA9. Interacts with DDB2; the interactions with DDB2 and CAND1 are mutually exclusive. Interacts with VPRBP, DTL, DDA1, DCAF6, DCAF4, DCAF16, DCAF17, DET1, WDTC1, DCAF5, DCAF11, WDR24A, RFWD2, PAFAH1B1, ERCC8, GRWD1, FBXW5, RBBP7, GNB2, WSB1, WSB2, NUP43, PWP1, FBXW8, ATG16L1, KATNB1, RBBP4, RBBP5 and DCAF8. May interact with WDR26, WDR51B, SNRNP40, WDR61, WDR76, WDR5. Can self-associate. Interacts with Epstein-Barr virus BPLF1.

Post-translational modifications:
Neddylated. Deneddylated via its interaction with the COP9 signalosome (CSN) complex (By similarity). Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome.

Similarity:
Belongs to the cullin family.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Cullin蛋白參與許多細(xì)胞功能的降解過程,包括細(xì)胞是否成長為成熟細(xì)胞、分裂或遭受凋亡的蛋白。cullin 4A主要調(diào)控血細(xì)胞。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
中文字幕无码家庭乱欲 | 欧美成人精品动漫在线专区 | 我国产码在线观看AV哈哈哈网站 | 麻豆传播媒体免费版官网 | 无码A级毛片日韩精品 | 国产精品美女www爽爽爽视频 | 美女裸胸不打马赛克 | 欧美大屁股XXXX高跟欧美黑人 | 兔费看少妇性L交大片免费 亚洲AV√最新天堂版资源地址在线官网 | 一本大道香蕉高清久久 | 国产午夜精品一区二区三区软件 | 免费的人成黄网站在线观看视频 | 国产网红在线_电影频道 | 少妇精品无码一区二区三区 | 亚洲精品国产第一综合99久久 | 啊轻点内射在线视频 | 天堂资源官网在线资源 | 一级a性色生活片久久无 | 一级卡片亚洲精品发布 | 少妇又紧又色又爽又刺激视频 | 亚洲中文乱伦无码免费看 | 午夜亚洲WWW湿好大 欧美又大又粗又硬又色A片 | 另类老妇奶性生BBWBBW | 人妻少妇看AA片偷人精品视频 | 波多野结衣高清无碼中文字幕 | 中国一级毛片在线观看 | 亚洲色偷偷综合亚洲AV伊人蜜桃 | 18禁美女裸体无遮挡免费观看国产 | 扒开老师大腿猛进AAA片软件 | 久久久精品国产亚洲成人满18免费网站 | 无码人妻免费—区二区三 | 欧美激情一区二区三区视频 | 成人满18在线观看网站免费 | 亚洲AⅤ永久无码精品毛片费观看 | 欧美一级视频精品观看 | 60老熟女多次高潮露脸视频 | 亚洲综合色区另类aV无码 | 亚洲 欧美 自拍 美腿 卡通 | 欧美A级毛欧美1级a大片式放 | 伊人婷婷涩六月丁香七月 | 亚洲熟妇一区二区三区 |