亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
亚洲人成人无码.WWW石榴,av色欲无码人妻中文字幕,国产97人人超碰cao蜜芽国产
Rabbit Anti-Estrogen Receptor alpha/APC Conjugated antibody (bs-0122R-APC)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0122R-APC
英文名稱 Rabbit Anti-Estrogen Receptor alpha/APC Conjugated antibody
中文名稱 APC標(biāo)記的雌激素受體α抗體
別    名 Estradiol receptor; Estrogen receptor alpha; Estradiol Receptor-alpha; Estrogen Receptor 1; Atherosclerosis, susceptibility to, included; DKFZp686N23123; ER Alpha; ER; ER-alpha; ERalpha; ER[a]; Era; ESR; ESR1; ESR1_HUMAN; ESR2; ESRA; Estr; Estrogen receptor 1 (alpha); Estrogen resistance, included; HDL cholesterol, augmented response of, to hormone replacement, included; Myocardial infarction, susceptibility to, included; NR3A1; Nuclear receptor subfamily 3 group A member 1; OTTHUMP00000017718; OTTHUMP00000017719; RNESTROR.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, Cow, Rabbit, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 67kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from the middle of human Estrogen Receptor alpha
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER Alpha and ER Beta. ER Alpha and ER Beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.

Function:
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Subunit:
Interacts with SLC30A9 (By similarity). Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2, FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
Glycosylated; contains N-acetylglucosamine, probably O-linked.

Similarity:
Belongs to the nuclear hormone receptor family. NR3 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 407238 Cow

Entrez Gene: 403640 Dog

Entrez Gene: 2099 Human

Entrez Gene: 13982 Mouse

Entrez Gene: 24890 Rat

Omim: 133430 Human

SwissProt: P49884 Cow

SwissProt: P03372 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

類固醇受體(Steroid Receptors)
雌激素受體ER-α(Estrogen Receptor-α, ERα)是一類位于細(xì)胞表面或細(xì)胞內(nèi)的特異性蛋白質(zhì)。
某些特異的雌激素、雌激素類似物、衍生物、拮抗劑或阻斷劑與它結(jié)合后可引發(fā)或阻斷受體蛋白質(zhì)的轉(zhuǎn)化作用。并將雌激素-受體復(fù)合物從細(xì)胞質(zhì)再定位進(jìn)入細(xì)胞核以啟動蛋白質(zhì)的生物合成。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
午夜无码片在线观看影院 | 欧美日韩精品国产一区在线 | 大学生一级毛片免费看** | 亚洲第一免费播放区 | 日本中文字幕乱码免费 | 久久精品国产免费中文 | 亚洲AⅤ日韩久久久久久 | 中文字幕一区中文亚洲 | 欧美A∨一区二区三区久久黄 | 偷窥欧美wc经典tv | 国产综合无码一区二区色蜜蜜 | 日韩精品无码一区二区免费A片 | 免费国产黄网在线观看 | 午夜欧美精品久久久久久久 | 十八破女处WWW视频 白丝校花 让我C在线观看91 | 欧美日韩一区二区三区人妻 | 蜜桃臀无码内射一区二区三区 | 欧美精品视频免费观看 | 欧美成人精品动漫在线专区 | 蜜桃羞羞小视频在线观看 | 一级a一级a爱片免费免免高潮 | 51ⅴ精品国产91久久久久久 | 亚洲一日欧美日韩中文字幕 | 国产精品无码免费专区午夜 | 亚瑟TV私人网站 | 亚洲国产一区二区精品专区发布 | 久久午夜一区二区 | 俺去俺来也在线www色官网 | 白浆内射不卡免费视频 | 国产乱女乱子视频在线播放 | 久久精品中文字幕第一页国产精品 | 日韩超碰人人爽人人做人人天 | 精品欧洲视频人人视频网站 | 原神乳液狂飙开襟网站MIMEI | av无码精品久久久久精品免费 | 国产精品无码无卡A级毛片 国产午夜精品理论片小yo奈 | 91精品国产91 | 黄桃AV无码免费一区二区三区 | 国产美女久久久久久久久久久 | 艳妇乳肉豪妇荡乳AV无码福利 | 动漫黄网站免费永久在线观看 |