亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
国产精品99久久久久久WWW,中国内射XXXX6981少妇
Rabbit Anti-Estrogen Receptor alpha/BF555 Conjugated antibody (bs-0122R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0122R-BF555
英文名稱 Rabbit Anti-Estrogen Receptor alpha/BF555 Conjugated antibody
中文名稱 BF555標(biāo)記的雌激素受體α抗體
別    名 Estradiol receptor; Estrogen receptor alpha; Estradiol Receptor-alpha; Estrogen Receptor 1; Atherosclerosis, susceptibility to, included; DKFZp686N23123; ER Alpha; ER; ER-alpha; ERalpha; ER[a]; Era; ESR; ESR1; ESR1_HUMAN; ESR2; ESRA; Estr; Estrogen receptor 1 (alpha); Estrogen resistance, included; HDL cholesterol, augmented response of, to hormone replacement, included; Myocardial infarction, susceptibility to, included; NR3A1; Nuclear receptor subfamily 3 group A member 1; OTTHUMP00000017718; OTTHUMP00000017719; RNESTROR.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  生長因子和激素  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human,  (predicted: Mouse, Rat, Dog, Cow, Rabbit, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 67kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from the middle of human Estrogen Receptor alpha
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER Alpha and ER Beta. ER Alpha and ER Beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.

Function:
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Subunit:
Interacts with SLC30A9 (By similarity). Binds DNA as a homodimer. Can form a heterodimer with ESR2. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with NCOA7 in a ligand-inducible manner. Interacts with PHB2, PELP1 and UBE1C. Interacts with AKAP13. Interacts with CUEDC2. Interacts with KDM5A. Interacts with SMARD1. Interacts with HEXIM1 and MAP1S. Interacts with PBXIP1. Interaction with MUC1 is stimulated by 7 beta-estradiol (E2) and enhances ERS1-mediated transcription. Interacts with DNTTIP2, FAM120B and UIMC1. Interacts with isoform 4 of TXNRD1. Interacts with MLL2. Interacts with ATAD2 and this interaction is enhanced by estradiol.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated by cyclin A/CDK2. Phosphorylation probably enhances transcriptional activity.
Glycosylated; contains N-acetylglucosamine, probably O-linked.

Similarity:
Belongs to the nuclear hormone receptor family. NR3 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 407238 Cow

Entrez Gene: 403640 Dog

Entrez Gene: 2099 Human

Entrez Gene: 13982 Mouse

Entrez Gene: 24890 Rat

Omim: 133430 Human

SwissProt: P49884 Cow

SwissProt: P03372 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

類固醇受體(Steroid Receptors)
雌激素受體ER-α(Estrogen Receptor-α, ERα)是一類位于細(xì)胞表面或細(xì)胞內(nèi)的特異性蛋白質(zhì)。
某些特異的雌激素、雌激素類似物、衍生物、拮抗劑或阻斷劑與它結(jié)合后可引發(fā)或阻斷受體蛋白質(zhì)的轉(zhuǎn)化作用。并將雌激素-受體復(fù)合物從細(xì)胞質(zhì)再定位進(jìn)入細(xì)胞核以啟動蛋白質(zhì)的生物合成。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产拍揄自揄免费观看 | 亚洲精品无人区在线观看 | 国产精品老师色诱在线 | 国产精品久久久久久搜索 | 亚洲欧美综合国产精品一区看三级 | 日韩欧美视频一区二区 | 国产主播福利一区二区 | 50岁寡妇下面水多好紧 | 女的被弄到高潮娇喘喷水视频 | 在线播放连续内射爽翻天vol | 香蕉视频免费在线观看 | 亚洲精品无人区在线观看 | 国产伦精品一区二区免费 | 中文在线中文资源 | 欧美人与禽交ZOZO | 中文字幕+乱码+中文乱码www | 欧美午夜精品久久久久久浪潮 | 亚洲啪AV永久无码精品放毛片 | 麻豆精品久久久一区二区 | 18岁日韩内射颜射午夜久久成人 | rion美乳弹出来四虎在线观看 | 特级淫片aaaa毛片aa视频 | 18禁美女裸体网站免费扒内衣 | 业佘老头视频man4 | 国产一区二区在线免费观看 | 91视频国产免费 | 超级最爽的乱淫片免费 | 女人18片毛片60分钟 | 国产精品久久久久国产A级 999国内精品永久免费视频 | 国产在线91精品入口 | 一级a免一级a做免费线看内裤 | 男女gif出入抽搐动态图 | 精品免费囯产一区二区三区四区 | 欧美freesex黑人又粗又大 | 91网站永久免费看nba视频 | 精品无人乱码高清在线观看 | 夜夜爱成人免费网站 | 国产精品免费露脸视频 | 亚洲一级AⅤ无码毛片不卡 亚洲精品白浆高清久久久久久 | 亚洲欧美日韩V在线播放 | 内射白浆一区二区在线观看 |