亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
精品人妻aV中文字幕乱码,国产后入又长又硬,免费看日产一区二区三区
Rabbit Anti-CHRDL2/BF594 Conjugated antibody (bs-3860R-BF594)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-3860R-BF594
英文名稱 Rabbit Anti-CHRDL2/BF594 Conjugated antibody
中文名稱 BF594標(biāo)記的乳腺腫瘤新因子1抗體
別    名 BNF1; Breast tumor novel factor 1; CHL2; chordin like 2; Chordin like protein 2 precursor; Chordin related protein 2; CRDL2_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買(mǎi)        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  免疫學(xué)  生長(zhǎng)因子和激素  血管內(nèi)皮細(xì)胞  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Cow, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 45kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human CHRDL2 C-terminus
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. A member of the chordin family of proteins, it contains a signal peptide and three CR (cysteine-rich repeat) domains. When expressed as a recombinant protein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors.

Function:
May inhibit BMPs activity by blocking their interaction with their receptors. Has a negative regulator effect on the cartilage formation/regeneration from immature mesenchymal cells, by preventing or reducing the rate of matrix accumulation (By similarity). Implicated in tumor angiogenesis. May play a role during myoblast and osteoblast differentiation, and maturation.

Subunit:
Interacts with GDF5 (By similarity). May interact with BMP2, BMP4, BMP5, BMP6, BMP7 and INHBA.

Subcellular Location:
Isoform 1: Secreted (Potential).
Isoform 2: Secreted (Potential).
Isoform 3: Cytoplasm (Potential).
Isoform 4: Cytoplasm (Potential).
Isoform 5: Cytoplasm (Potential).

Tissue Specificity:
Highly expressed in uterus. Moderately expressed in heart, liver, prostate, testis and ovary. Weakly expressed in skeletal muscle, kidney, spleen, small intestine and colon. Expressed in the secretory epithelial cells of uterine endometrium, fallopian tubes, endocervical glands, bladder and prostate, as well as the transitional epithelium of the urinary bladder, and in bone osteoblasts (at protein level). In normal cartilage, expression was confined in a few chondrocytes in the superficial zone as well as in the middle zone. In diseased cartilage coming from osteoarthritic patients, expression was limited to the middle zone of chondrocytes. Isoform 1 and isoform 2 are expressed in fetal cerebellum and heart, while only isoform 2 is detected in fetal spleen. Isoform 2 present in plasma.

Post-translational modifications:
Phosphorylation sites are present in the extracellular medium. Isoform 2 is phosphorylated on Ser-402.

Similarity:
Contains 3 VWFC domains.

Database links:

Entrez Gene: 25884 Human

Omim: 613127 Human

SwissProt: Q6WN34 Human

Unigene: 432379 Human

 



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CHRDL2原來(lái)主要用于乳腺癌的研究,近年來(lái)研究發(fā)現(xiàn)在腫瘤中也有發(fā)現(xiàn),目前在肺癌,結(jié)腸腫瘤的研究中應(yīng)用較多。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書(shū)編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書(shū)編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
亚洲精品一二三区尤物tv | 国产精品爱啪在线线免费观看 | 91桃色无码国产在线观看二区 | 亚洲精品毛片一级AV | 忘忧草在线社区WWW日本-韩国 | 欧美三级在线免费观看 | 亚洲欧美码明星卡通重口 | 免费看片A级毛片免费看 | 欧美成人性色生活18黑人 | 9久9久女女免费视频精品 | 日本BBW丰满牲交片 国产精品国产三级国产AV剧情 | 日本久久精品视频 | 久久精品中文骚妇内射AV | 色青青草原桃花久久综合 | 在线精品亚洲欧美日韩国产 | 婷婷五月综合缴情在线视频 | 久久高清内射无套 | 亚洲AV一宅男色影视 | 宝贝腿开大点我添添公视频免费 | 免费无码又爽又黄又刺激网站 | 亚欧洲精品在线视频免费观看 | 小短文H啪纯肉公交车 | 成人在线免费电影 | 最新上传免费网友自拍视频 | a毛片在线看免费观看 | 精品日本亚洲一区二区三区 | 免费无毒a网站在线观看 | 国产午夜精品片一区二区三区 | 人妻体体内射精一区二区 | 亚洲春色Av无码专区 | 精品21国产成人综合网在线 | 宝贝别忍着喷出来嗯啊哦漫画 | 亚洲AV怡红院影院怡春院 | 亚洲国产精品高清免费在线观看 | 无码人妻丰满熟妇片毛片 | 五月的丁香六月的婷婷免费无毒不卡 | 成人免费视频在线观看 | 无码视频AⅤ在线观看 | 美女扒开内裤羞羞网站 | 国产午夜精品片一区二区三区 | 91热久久免费频精品动漫99 |