亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
美女祼体无遮挡又污又黄又爽视频在线看,国产主播福利一区二区
Rabbit Anti-Megalin/Cy7 Conjugated antibody (bs-3909R-Cy7)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-3909R-Cy7
英文名稱 Rabbit Anti-Megalin/Cy7 Conjugated antibody
中文名稱 Cy7標(biāo)記的糖蛋白gp330抗體
別    名 Calcium sensor protein; DBS; Glycoprotein 330; gp330; Heymann nephritis antigen homolog; Low-density lipoprotein receptor-related protein 2; LRP-2; Lrp2; LRP2_HUMAN.  
Journal
PMID
IF
Application
[IF=8.43] Giani et al. Renal tubular angiotensin converting enzyme is?responsible for nitro-L-arginine methyl ester?(L-NAME)-induced salt sensitivity. (2017) Kidney.Int. 91:856-867  FC ;  Mouse.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  糖尿病  糖蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Chicken, Dog, Horse, Rabbit, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 519kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Lrp2/Megalin
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009].

Function:
Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release.

Subunit:
Binds plasminogen, extracellular matrix components, plasminogen activator-plasminogen activator inhibitor type I complex, apolipoprotein E-enriched beta-VLDL, lipoprotein lipase, lactoferrin, CLU/clusterin and calcium. Forms a multimeric complex together with a receptor-associated protein (RAP). Binds to ankyrin-repeat family A protein 2 (ANKRA2). Interacts with LRP2BP.

Subcellular Location:
Membrane; Single-pass type I membrane protein. Membrane, coated pit.

Tissue Specificity:
Absorptive epithelia, including renal proximal tubules.

DISEASE:
Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS) [MIM:222448]; also known as faciooculoacousticorenal syndrome (FOAR syndrome). DBS is a rare autosomal recessive disorder characterized by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the classic distinguishing features between the 2 disorders were presence of proteinuria and absence of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2 disorders shared many phenotypic features and may be identical. Although there is variability in the expression of some features (e.g. agenesis of the corpus callosum and proteinuria), DBS and FOAR are now considered to represent the same entity.

Similarity:
Belongs to the LDLR family.
Contains 17 EGF-like domains.
Contains 36 LDL-receptor class A domains.
Contains 37 LDL-receptor class B repeats.

Database links:

Entrez Gene: 4036 Human

Entrez Gene: 14725 Mouse

Entrez Gene: 29216 Rat

Omim: 600073 Human

SwissProt: P98164 Human

SwissProt: A2ARV4 Mouse

SwissProt: P98158 Rat

Unigene: 657729 Human

Unigene: 23847 Mouse

Unigene: 26430 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Lrp2屬于低密度脂蛋白受體家族成員,是腎小管重吸收白蛋白的重要受體蛋白。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
国产精品黄在线观看免费网站 | 91天堂在线视频 | 国产伦精品免编号公布 | 精品1区2区3区产品乱码 | 中文字幕欧美另类精品亚洲 | 欧美另类精品xxxx | 国产精品一区二区AV日韩在线 | 91手机在线视频观看 | 午夜色大片在线观看 | 国产精品第1页在线观看 | 两口子交换真实刺激高潮 | 日韩视频高清免费看 | 麻豆精产国品一二三产区区别在哪 | 国产精品久久综合桃花网 | 亚洲国产成人精品无码av不卡久久久久 | 国产成人精品久久综合 | 亚洲乱妇老熟女爽到高潮的片 | 精品国产一区二区三区 | 一级a性色生活片久久毛片 日韩欧美一中文字慕2O22 | 中文字幕无码一区二区免费 | 国产精品福利午夜在线观看 | 精品亚洲AV无码一区二区三区在线 | 人妻体体内射精一区二区三区电影 | 一区二区三区国产亚洲网站 | 最新欧美精品二区三区 | 国产精品无码AV片在线专区 | 女人高潮爽到全身痉挛抽搐 | 成人影片麻豆国产影片免费观看 | 四虎永久在线精品国产免费 | 波多野结衣高清无碼中文字幕 | 久99久热只有精品国产女同 | 色综合精品无码一区二区三区 | 久久精品欧美一区二区三区不卡 | 国产超碰人人模人人爽人人添 | 国产后入又长又硬 | 亚洲AV中文无码字幕色三 | 国产在线观看www鲁啊鲁免费 | 免费无码又爽视频在线观看 | 国产免费看又黄又大又污的胸 | 精品国产在天天线在线 | 人妻少妇精品久久久久久0000 |