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Rabbit Anti-FGF8/PE-Cy5 Conjugated antibody (bs-0735R-PE-Cy5)
訂購(gòu)熱線:400-901-9800
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說(shuō) 明 書(shū): 100ul  
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0735R-PE-Cy5
英文名稱 Rabbit Anti-FGF8/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標(biāo)記的成纖維細(xì)胞生長(zhǎng)因子8抗體
別    名 AIGF; Androgen induced growth factor; Androgen-induced growth factor; FGF 8; FGF-8; FGF8; Fibroblast growth factor 8 (androgen induced); Fibroblast growth factor 8 precursor; HBGF 8; HBGF-8; HBGF8; FGF8_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書(shū) 100ul  
研究領(lǐng)域 腫瘤  細(xì)胞生物  免疫學(xué)  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Rat,  (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 27kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human FGF8
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Keratinocyte growth factor precursor (KGF) (Fibroblast growth factor 8; FGF-8; HBGF-8). Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells. Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis. [Subcellular location] Secreted. [Tissue specificity] Absent in normal mammary glands and detected only in adult testis and ovary and in midgestational embryos. [Induction] By androgens. Belongs to the heparin-binding growth factors family.

Function:
Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells.

Subunit:
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.

Subcellular Location:
Secreted.

DISEASE:
Defects in FGF8 are the cause of Kallmann syndrome type 6 (KAL6) [MIM:612702]. Kallmann syndrome is a disorder that associates hypogonadotropic hypogonadism and anosmia. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In some patients other developmental anomalies can be present, which include renal agenesis, cleft lip and/or palate, selective tooth agenesis, and bimanual synkinesis. In some cases anosmia may be absent or inconspicuous.

Similarity:
Belongs to the heparin-binding growth factors family.

Database links:

Entrez Gene: 2253 Human

Entrez Gene: 14179 Mouse

Entrez Gene: 29349 Rat

Omim: 600483 Human

SwissProt: P55075 Human

SwissProt: P37237 Mouse

Unigene: 57710 Human

Unigene: 4012 Mouse

Unigene: 73565 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

有研究者認(rèn)為:纖維母細(xì)胞生長(zhǎng)因子8 FGF8 對(duì)癌癥具有一定的抑制作用。
早期研究FGF8,認(rèn)為是自分泌生長(zhǎng)因子,它在前列腺癌、乳癌和卵巢癌中常常表現(xiàn)過(guò)量表達(dá) (over-expressed),并與前列腺癌的格里森分?jǐn)?shù) (Gleason score) 相關(guān)聯(lián)。經(jīng)過(guò)各種細(xì)胞和動(dòng)物模型的實(shí)驗(yàn)均支持FGF8在抑制腫瘤形成和腫瘤細(xì)胞成活方面的作用。
此外,還有學(xué)者認(rèn)為:FGF8 還在實(shí)驗(yàn)中顯示出,他有改善因膠原蛋白引發(fā)的關(guān)節(jié)炎性的改變,如:風(fēng)濕性關(guān)節(jié)炎和類風(fēng)濕性關(guān)節(jié)炎及退行性骨性關(guān)節(jié)病。
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