亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
欧美精品在欧美一区二区少妇,人人人人爽人人人人爱
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Rabbit Anti-HSPG2/Heparan Sulfate Proteoglycan 2/Cy3 Conjugated antibody (bs-5072R-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-5072R-Cy3
英文名稱 Rabbit Anti-HSPG2/Heparan Sulfate Proteoglycan 2/Cy3 Conjugated antibody
中文名稱 Cy3標記的硫酸乙酰肝素蛋白多糖2抗體
別    名 Heparan Sulphate Proteoglycan; Perlecan; Basement membrane specific heparan sulfate proteoglycan core protein; Endorepellin (domain V region); Heparan Sulfate Proteoglycan; Heparan sulfate proteoglycan of basement membrane; HSPG 2; HSPG; Hspg2; LG3 peptide; Perlecan; PLC antibody Schwartz Jampel syndrome 1 (chondrodystrophic myotonia); SJA antibody SJS antibody SJS1 antibody.   
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  免疫學  轉錄調節(jié)因子  糖蛋白  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human,  (predicted: Mouse, Rat, Pig, Cow, Horse, )
產(chǎn)品應用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 469kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Heparan Sulfate Proteoglycan 2
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans(heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010].

Function:
Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development.
[FUNCTION] Endorepellin in an anti-angiogenic and anti-tumor peptide that inhibits endothelial cell migration, collagen-induced endothelial tube morphogenesis and blood vessel growth in the chorioallantoic membrane. Blocks endothelial cell adhesion to fibronectin and type I collagen. Anti-tumor agent in neovascularization. Interaction with its ligand, integrin alpha2/beta1, is required for the anti-angiogenic properties. Evokes a reduction in phosphorylation of receptor tyrosine kinases via alpha2/beta1 integrin-mediated activation of the tyrosine phosphatase, PTPN6.

The LG3 peptide has anti-angiogenic properties that require binding of calcium ions for full activity.

Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane.

Tissue Specificity:
Found in the basement membranes.

Post-translational modifications:
Proteolytic processing produces the C-terminal angiogenic peptide, endorepellin. This peptide can be further processed to produce the LG3 peptide.
N- and O-glycosylated; contains three heparan sulfate chains. The LG3 peptide contains at least three and up to five potential O-glycosylation sites but no N-glycosylation.

Similarity:
Contains 4 EGF-like domains.
Contains 22 Ig-like C2-type (immunoglobulin-like) domains.
Contains 11 laminin EGF-like domains.
Contains 3 laminin G-like domains.
Contains 3 laminin IV type A domains.
Contains 4 LDL-receptor class A domains.
Contains 1 SEA domain.

Database links:

Entrez Gene: 444872 Cow

Entrez Gene: 3339 Human

Entrez Gene: 15530 Mouse

Omim: 142461 Human

SwissProt: P98160 Human

SwissProt: Q05793 Mouse

Unigene: 562227 Human

Unigene: 273662 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
欧美精品一区二区三区久久久精品 | 国产又粗又猛又爽又黄的视频免费软件 | 亚洲婷婷国产精品电影人久久 | 原神胡桃开襟乳液狂飙 | 国产无遮挡色视频免费观看性色 | 日韩欧美一区二区中文字幕 | 日本aa免费电影 | 99国精品午夜福利视频不卡 | 黄成人app网站在线看 | 激情内射亚洲一区二区三区爱妻 | 国产欧美一区二区精品性色超碰 | 粉嫩METART人体欣赏 | 国产无吗一区二区三区在线欢 | 久久毛片免费看一区二区三区 | 免费午夜无码18禁无码影视 | 精品99久久一A毛免费观看 | EEUSS鲁丝片EEUSS影院 | 欧美自拍嘿咻内射在线观看 | 97久久久人妻一区精品 | 亚洲欧美一区二区三区图片 | 精品视频一区二区三区中文字幕 | 学生妹无套内射正在播放 | 少妇自慰白浆一区二区 | 国产成人精品AA毛片 | 伊人久久大香线蕉综合网站 | 久久国产精品高清一区二区三区 | 午夜亚洲国产理论片一二三四 | 公车痴汉媚药强抹在线观看 | 在线观看黄网视频免费播放 | 精品国产成人亚洲午夜福利 | 国产亚洲AV片在线观看16女人 | 一级毛片久久久久久久女人18 | 成人毛片100免费观看 | 国产精品香蕉在线的人 | 国产日韩亚洲VA无码自线免费看不卡 | 超碰国产精品人人做人人爱 | 美妇吞吐粗长撞击迎合 | 久久久精品中文字幕麻豆发布 | 亚洲高清一区二区三区电影 | 囯产精品一区二区三区线 | 后入白嫩网红内射99XYZ |