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Rabbit Anti-ILK-1/BF555 Conjugated antibody (bs-0317R-BF555)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0317R-BF555
英文名稱 Rabbit Anti-ILK-1/BF555 Conjugated antibody
中文名稱 BF555標記的整合素連接激酶-1抗體
別    名 59 kDa serine/threonine protein kinase; 59 kDa serine/threonine-protein kinase; ILK-2; ILK_HUMAN; Integrin linked Kinase; Integrin-linked protein kinase; DKFZp686F1765; EC 2.7.11.1; ILK 1; ILK 2; ILK; ILK1; ILK2; Integrin linked Kinase 2; Integrin linked protein kinase; p59; p59ILK.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  神經(jīng)生物學  信號轉(zhuǎn)導(dǎo)  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat,  (predicted: Chicken, Dog, Cow, )
產(chǎn)品應(yīng)用 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 50kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human ILK-1 (351-400aa)
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin linked kinase (ILK), interacts with the cytoplasmic domain of beta 1 Integrin. ILK encodes a predicted 451 amino acid protein, with an apparent molecular weight of 59 kDa. The ILK protein is a serine/threonine protein kinase with 4 ankyrin like repeats. ILK regulates integrin mediated signal transduction.
The ILK protein is important in different biological pathways such as cell adhesion, anchorage-dependent cell cycle progression, oncogenic transformation, and growth factor signaling. The kinase activity of ILK is low in non-activated cells; its activity is stimulated by cell-ECM interactions and by certain growth factors. 3 Negative regulation of ILK is mediated by two phosphatases: PTEN, a tumor suppressor lipid sphatase, and ILKAP, a PP2C protein phosphatase. In tumor cells that do not express PTEN protein, ILK is constitutively active.

Function:
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.

Subunit:
Interacts with cytoplasmic domain of beta 1 subunit of integrin. Could also interacts with beta 2, beta 3 and/or beta 5 subunit of integrin. Interacts (via ANK repeats) with LIMS1 and LIMS2. Interacts with parvins and probably TGFB1I1. Interacts (via ANK repeats) with EPHA1 (via SAM domain); stimulated by EFNA1 but independent of the kinase activity of EPHA1.

Subcellular Location:
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Tissue Specificity:
Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.

Post-translational modifications:
Autophosphorylated on serine residues.

Similarity:
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Contains 5 ANK repeats.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 3611 Human

Entrez Gene: 16202 Mouse

Entrez Gene: 170922 Rat

Omim: 602366 Human

SwissProt: Q13418 Human

SwissProt: O55222 Mouse

SwissProt: Q99J82 Rat

Unigene: 5158 Human

Unigene: 706355 Human

Unigene: 274846 Mouse

Unigene: 95042 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

ILK 是一種新發(fā)現(xiàn)的Ser/Thr蛋白激酶。ILK能夠通過與整合素β1亞單位的結(jié)合介導(dǎo)細胞與胞外基質(zhì)的連接,以依賴于PI3K的方式激活,并通過磷酸化下游底物PKB/AKT,GSK3等胞外信號的一項下游傳遞,對細胞的生長,分化,遷移等進行調(diào)控。由于ILK在胞內(nèi)外信號傳導(dǎo)中起著重要的作用。并且抑制ILK的活性能夠?qū)е录毎芷诘耐图毎绦蛐运劳龅膯?,使其成為腫瘤治療和腫瘤藥物的理想靶位點。
該蛋白也表達與腎小球系膜細胞,正常足細胞ILK的高水平表達對足細胞功能起著重要的生理作用。DN 患者ILK表達明顯增加 ,暴露于高血糖的腎小球膜細胞的ILK 水平明顯升高, ILK 與整合素和其他連接蛋白都受到高血糖的調(diào)節(jié),并且促進DN 患者腎小球基質(zhì)的沉積。
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