亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號(hào)           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
东北女人一级毛片,2021年日本中文字幕在线
Rabbit Anti-Glucocorticoid receptor/Gold Conjugated antibody (bs-0252R-Gold)
訂購(gòu)熱線:400-901-9800
訂購(gòu)郵箱:sales@bioss.com.cn
訂購(gòu)QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說(shuō) 明 書: 100ul(10nm  15nm  35nm
100ul/2980.00元
大包裝/詢價(jià)
產(chǎn)品編號(hào) bs-0252R-Gold
英文名稱 Rabbit Anti-Glucocorticoid receptor/Gold Conjugated antibody
中文名稱 膠體金標(biāo)記的糖皮質(zhì)激素受體抗體
別    名 glucocorticoid receptor isoform alpha; GCCR; GCR; GR; Nuclear receptor subfamily 3 group C member 1; Glucocorticoid receptor lymphocyte; GRL; Grl1; Nr3c1; NR3C1; GCR_HUMAN.  
規(guī)格價(jià)格 100ul/2980元 購(gòu)買        大包裝/詢價(jià)
說(shuō) 明 書 100ul(10nm  15nm  35nm
研究領(lǐng)域 免疫學(xué)  G蛋白偶聯(lián)受體  
抗體來(lái)源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, 
產(chǎn)品應(yīng)用 IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 85kDa
性    狀 Lyophilized or Liquid
濃    度 0.4mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human Glucocorticoid receptor
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
保存條件 Store at 2-8 oC for 3-6 months. Avoid repeated freeze/thaw cycles.
產(chǎn)品介紹 background:
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]

Function:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity).

Subunit:
Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP5 or another immunophilin, or the immunophilin homolog PPP5C. Directly interacts with UNC45A. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates (By similarity). Binds to DNA as a homodimer, and as a heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity). Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1.

Subcellular Location:
Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding.
Isoform Beta: Nucleus. Note=Localized largely in the nucleus.

Tissue Specificity:
Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart.

DISEASE:
Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant.

Similarity:
Belongs to the nuclear hormone receptor family. NR3 subfamily.
Contains 1 nuclear receptor DNA-binding domain.

Database links:

Entrez Gene: 2908 Human

Entrez Gene: 14815 Mouse

Entrez Gene: 24413 Rat

Omim: 138040 Human

SwissProt: P04150 Human

SwissProt: P06537 Mouse

SwissProt: P59667 Rabbit

SwissProt: P06536 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

甾體激素受體(Steroid Receptors)
GR廣泛分布于多種淋巴組織及器官,存在于免疫細(xì)胞的胞漿及核內(nèi)。
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過(guò)國(guó)際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號(hào): 00124Q34771R2M/1100
通過(guò)國(guó)際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號(hào): CQC24QY10047R0M/1100
京ICP備05066980號(hào)-1         京公網(wǎng)安備110107000727號(hào)
永久免费一级av毛片网站 | 国产精品免费久久久久软件 | 精品国产粉嫩内射白浆内射双马尾 | 97久久超碰亚洲视觉盛宴 | 亚洲AV成人一区二区三区在线看 | 欧美一级毛片在播放免费 | 色婷婷综合激情中文在线 | 国产麻豆91网在线看 | 天堂资源中文最新版在线一区 | 奶大交一乱一乱一视一频 | 国产毛片久久久久久国产毛片 | 男男体育生乱yin高H肉汁 | 久久99国产精品一区二区 | 亚洲欧美国产精品专区久久综合高清 | 边做饭边被躁在线播放 | 国产高颜值大学生情侣酒店 | 特级毛片A级毛片免费观看网站 | 国产日韓无码一区二区三区久久区 | a一级毛片视频免费看 | 最近中文字幕大全在线电影视频 | 久久久久久久久久国产精品免费 | 丰满岳妇乱一区二区三区 | 亚洲欧美码明星卡通重口 | 痉挛大量潮喷精品无码视频 | 欧美a级成人淫片免费看日韩三级一级 | 禁欲总裁被C呻吟双腿大张 亚洲欧美日韩中文久久 | 小龙女玉足娇喘蕾丝湿润 | 永久免费观看精品视频 | 你的欲梦裸身在线播放 | 九九热精品视频在线观看 | 18禁美女裸体网站免费扒内衣 | 极品尤物喷水爆白浆呻吟小说 | 亚色九九九全国免费视频 | 40岁成熟女人牲交片 | 国产成人无码区免费内射一片色欲 | 在线播放中文字幕 | 91热成人精品国产免费 | 91极品女神私人尤物在线播放 | 中文字幕亚洲综合久久菠萝蜜 | 亚洲精品免费网站 | 欧美精品黄网站在线播放 |