亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關(guān)注公眾號           掃碼咨詢技術(shù)支持           掃碼咨詢技術(shù)服務(wù)
  
客服熱線:400-901-9800  客服QQ:4009019800  技術(shù)答疑  技術(shù)支持  質(zhì)量反饋  關(guān)于我們  聯(lián)系我們
久久精品www人人爽人人,最近日本字幕MV高清在线观看
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Mouse Anti-IDE/PE-Cy3 Conjugated antibody (bs-0018M-PE-Cy3)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術(shù)支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0018M-PE-Cy3
英文名稱 Mouse Anti-IDE/PE-Cy3 Conjugated antibody
中文名稱 PE-Cy3標記的胰島素降解酶抗體
別    名 BC2; Insulin degrading enzyme; FLJ35968; insulin protease; insulinase; insulysin; Abeta-degrading protease; FLJ35968; Ide; IDE_HUMAN; Insulin-degrading enzyme; OTTHUMP00000020097.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 腫瘤  心血管  細胞生物  免疫學(xué)  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  生長因子和激素  糖尿病  內(nèi)分泌病  Alzheimer's  
抗體來源 Mouse
克隆類型 Polyclonal
交叉反應(yīng) (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, )
產(chǎn)品應(yīng)用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 117kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IDE
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Insulysin was identified nearly a century ago as an enzyme responsible for the degradation of insulin in cells, although the precise interactions between insulin and insulysin remain elusive. Human insulysin was cloned in 1988, and shown to be a 118 kDa protein that exists primarily as a homodimer, and perhaps also complexed with other molecules. The sequence is well conserved between humans, rats and mice, and the antibody recognizes these species. Insulysin is a metalloproteinase of the clan ME, family M16, which contains an active site HxxEH, a reversal of the canonical HExxH zinc binding motif. Considered a zinc metalloproteinase, the activity of insulysin can be blocked with EDTA or 1-10 phenanthroline. In addition to the active metalloproteinase domain, insulysin contains a second metalloproteinase site which is considered catalytically inactive, and is thought to assist in substrate binding. Insulysin is most closely related to the bacterial proteinase pitrilysin, (the human orthologue of which appears to be MPRP1) and the mammalian proteinsae nardilysin. Generally thought to be a cytoplasmic protein, insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B chain, glucagon, denatured hemoglobin, alpha amyloid protein, TGF alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer’s disease research. The pH optimum for insulysin is basic, pH 8.5, which also distinguishes it from other metalloproteinases.
Insulin degrading enzyme (IDE) has a preferential affinity for insulin such that the presence of insulin will inhibit IDE mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma secretase cleaved APP that may function in nuclear signaling.

Function:
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.

Subunit:
Homodimer. Can form higher oligomers. Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus.

Subcellular Location:
Cytoplasm. Cell surface. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.

Post-translational modifications:
The N-terminus is blocked.

Similarity:
Belongs to the peptidase M16 family.

Database links:

Entrez Gene: 3416 Human

Entrez Gene: 15925 Mouse

Entrez Gene: 25700 Rat

Omim: 146680 Human

SwissProt: P14735 Human

SwissProt: Q9JHR7 Mouse

SwissProt: P35559 Rat

Unigene: 500546 Human

Unigene: 28366 Mouse

Unigene: 45029 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權(quán)所有 2004-2026 www.a6308.cn 北京博奧森生物技術(shù)有限公司
通過國際質(zhì)量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質(zhì)量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
日本电影一区二区 | 国产JK白丝AV在线播放 | 日韩一区二区三区射精 | 极品人妻少妇一区二区三区 | 日韩精品欧美在线视频在线 | A级毛片无码久久精品免费 九九视频精品全部免费播放 | 欧美激情一区二区三区视频 | 日韩福利视频精品专区 | 囯产精品一区二区三区线 | 国产一级片内射毛片中出91 | 亚洲无码AV一区二区 | 中文熟妇人妻又伦精品 | 亚欧洲乱码视频一二三区 | 天天做天天添天天谢 | 精品性影院一区二区三区内射 | 《色诱女教师》在线观看 | 成人午夜性A级毛片免费 | 欧美亚洲性色影视在线 | 国产伦精品一区二区三区妓女 | 免费下载黄色app | 亚洲精品中文无码AV在线播放 | 天堂MV在线MV免费MV香蕉 | 久久爱影院久久99久国产 | 曰本a级毛片无卡免费视频 自拍偷区亚洲综合第一页欧18 | 一牛影视传媒有限公司官网 | 国产人人怕人人干视频 | 免费永久在线观看黄网 | 国产AV电影区二区三区曰曰骚网 | 国产高清国内精品福利色噜噜 | 久久精品99国产精品日本 | 欧美一级久久久久久久久大 | 日本黄色成年人免费观看 | √天堂中文在线最新版 | miaa213永濑唯在线观看 | 国产在线视频福利 | 日本妇人成熟A片免费观看 亚洲精品永久在线观看 | 国产精品成人观看视频免费 | 91国语精品自产拍在线观看性色 | 亚洲AⅤ永久无码精品毛片费观看 | 日本成人激情视频 | 18禁黄网站禁片免费观看久久 |