亚洲制服欧美另类-午夜激情av电影-日本高清中文字幕一区二区三区-中国欧美日韩一区二区三区-欧洲亚洲日本韩国-成人欧美激情一区二区-亚洲偷偷自拍高清

掃碼關注公眾號           掃碼咨詢技術支持           掃碼咨詢技術服務
  
客服熱線:400-901-9800  客服QQ:4009019800  技術答疑  技術支持  質量反饋  關于我們  聯(lián)系我們
亚洲国产精品午夜福利在线观看,欧美日韩在线精品一区二区三区激情综合
首頁 > 產(chǎn)品中心 > 標記一抗 > 產(chǎn)品信息
Mouse Anti-IDE/PE-Cy5.5 Conjugated antibody (bs-0018M-PE-Cy5.5)
訂購熱線:400-901-9800
訂購郵箱:sales@bioss.com.cn
訂購QQ:  400-901-9800
技術支持:techsupport@bioss.com.cn
說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-0018M-PE-Cy5.5
英文名稱 Mouse Anti-IDE/PE-Cy5.5 Conjugated antibody
中文名稱 PE-Cy5.5標記的胰島素降解酶抗體
別    名 BC2; Insulin degrading enzyme; FLJ35968; insulin protease; insulinase; insulysin; Abeta-degrading protease; FLJ35968; Ide; IDE_HUMAN; Insulin-degrading enzyme; OTTHUMP00000020097.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領域 腫瘤  心血管  細胞生物  免疫學  神經(jīng)生物學  信號轉導  生長因子和激素  糖尿病  內(nèi)分泌病  Alzheimer's  
抗體來源 Mouse
克隆類型 Polyclonal
交叉反應 (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, )
產(chǎn)品應用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 117kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human IDE
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
Insulysin was identified nearly a century ago as an enzyme responsible for the degradation of insulin in cells, although the precise interactions between insulin and insulysin remain elusive. Human insulysin was cloned in 1988, and shown to be a 118 kDa protein that exists primarily as a homodimer, and perhaps also complexed with other molecules. The sequence is well conserved between humans, rats and mice, and the antibody recognizes these species. Insulysin is a metalloproteinase of the clan ME, family M16, which contains an active site HxxEH, a reversal of the canonical HExxH zinc binding motif. Considered a zinc metalloproteinase, the activity of insulysin can be blocked with EDTA or 1-10 phenanthroline. In addition to the active metalloproteinase domain, insulysin contains a second metalloproteinase site which is considered catalytically inactive, and is thought to assist in substrate binding. Insulysin is most closely related to the bacterial proteinase pitrilysin, (the human orthologue of which appears to be MPRP1) and the mammalian proteinsae nardilysin. Generally thought to be a cytoplasmic protein, insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B chain, glucagon, denatured hemoglobin, alpha amyloid protein, TGF alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer’s disease research. The pH optimum for insulysin is basic, pH 8.5, which also distinguishes it from other metalloproteinases.
Insulin degrading enzyme (IDE) has a preferential affinity for insulin such that the presence of insulin will inhibit IDE mediated degradation of other substrates. IDE degrades a variety of other peptides including atrial natriuretic peptide and amylin. IDE catabolizes A beta and has been implicated as a candidate enzyme responsible for the degradation and clearance of A beta in the brain. IDE has also been shown to degrade the APP intracellular domain (AICD), a product of gamma secretase cleaved APP that may function in nuclear signaling.

Function:
Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.

Subunit:
Homodimer. Can form higher oligomers. Interacts (via N-terminus) with varicella-zoster virus (VZV) envelope glycoprotein E (via N-terminus); the membrane-associated isoform may function as an entry receptor for this virus.

Subcellular Location:
Cytoplasm. Cell surface. Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.

Post-translational modifications:
The N-terminus is blocked.

Similarity:
Belongs to the peptidase M16 family.

Database links:

Entrez Gene: 3416 Human

Entrez Gene: 15925 Mouse

Entrez Gene: 25700 Rat

Omim: 146680 Human

SwissProt: P14735 Human

SwissProt: Q9JHR7 Mouse

SwissProt: P35559 Rat

Unigene: 500546 Human

Unigene: 28366 Mouse

Unigene: 45029 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
版權所有 2004-2026 www.a6308.cn 北京博奧森生物技術有限公司
通過國際質量管理體系ISO 9001:2015 GB/T 19001-2016    證書編號: 00124Q34771R2M/1100
通過國際醫(yī)療器械-質量管理體系ISO 13485:2016 GB/T 42061-2022    證書編號: CQC24QY10047R0M/1100
京ICP備05066980號-1         京公網(wǎng)安備110107000727號
粗大的内捧猛烈进出在线视频 | 久久av无码av高潮av喷吹捆绑 | 日韩欧美一区二区三区免费观看 | 日韩高清成片免费视频 | 丝袜精品人妻自慰喷白浆一区 | 五月丁香久久伊人本道开心 | 亚洲春色cameltoe一区 | 不卡在线播放一区二区三区 | 国产思思热视频在线观看 | 国产AV电影区二区三区曰曰骚网 | 免费特黄一区二区三区视频一 | 国产美女一区二区 | 久久久久久亚洲综合网站 | 亚洲AV成人无码网天堂 | 精品无码国产污污污免费网站 | 成年免费视频黄网站在线观看 | 我两腿被同学摸的直流水 | 欧美日韩精品一区二区在线播放蜜臀 | 久久精品国产欧美日韩99热 | 99国产精品一区二区三区四区五区 | 麻豆一区二区大豆行情 | 亚洲精品美女久久久久99 | 国产免费无码XXXXX视频 | 日欧片内射AV影院频道 | 超级乱淫小黄文小说 | 久久综合久久一区二区 | 在线日韩制服中文字幕视频 | 97超级碰碰碰久久久久总站 | 99久久精品免费看国产一区二区三区 | 高清国产激情视频在线观看 | 国产高清秘?成人久久 | 久久综合九色综合网站 | 成年女人18级毛片毛片免费观看 | 精品21国产成人综合网在线 | 天堂中文最新版在线官网在线 | 中文字幕一区视频一线 | 亚洲日本欧美产综合在线 | 91国语精品自产拍在线观看性色 | 特级做a爰片毛片免费看 | 亚洲色欲色郤久久综合影院 | 久久99人妻无码精品一区二区 |